Effects of nutritional status and dietetic interventions on survival in Cystic Fibrosis patients before and after lung transplantation

F.M. Hollander, D.D. van Pierre, N.M. de Roos, E.A. van de Graaf, J.A. Iestra

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34 Citations (Scopus)

Abstract

Background: This study retrospectively investigated nutritional status, dietetic intervention and intake in Cystic Fibrosis (CF) patients before and after lung transplantation (LTX). Methods: Body Mass Index (BMI), Fat Free Mass Index (FFMI) and nutritional intake were retrieved from 75 out-patients aged 15-53 years. Patients were seen every 3-4 months during the waiting list time (range 0-81 months) and up to 116 months after LTX. Survival was measured in months. Results: The median BMI at baseline was 19.2 kg/m(2) (range: 15.3 to 28.4 kg/m(2)) with 29 patients (39%) below = 500 kcal less than recommended. Protein intake was 104 (range 60-187) g or 1.9 g/kg per day. Despite dietetic intervention with oral nutritional supplements (ONS) (36 patients), tube feeding (12 patients), or both (13 patients), HMI and FFMI hardly improved pre-LTX. LTX was performed in 51 patients (68%); 10 patients died during follow-up, median survival time was 41 months. A BMI 18.5 kg/m(2) was more prevalent in patients who died before LTX (6/9) or who died after LTX (4/10) than in patients who were still alive on the waiting list (5/15) or who survived LTX (14/41). Results for FFMI were comparable. From 6-12 months post-LTX, BMI and FFMI markedly improved, especially in underweight patients. Conclusion: A BMI
Original languageEnglish
Pages (from-to)212-218
JournalJournal of Cystic Fibrosis
Volume13
Issue number2
DOIs
Publication statusPublished - 2014

Keywords

  • body-mass index
  • fat-free mass
  • percutaneous endoscopic gastrostomy
  • weight-gain
  • adults
  • bioimpedance
  • candidates
  • overweight
  • recipients
  • impedance

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