Effects of inclusion of hydrolyzed yeast on the immune response and performance of piglets after weaning

F. Molist, E. van Eerden, H.K. Parmentier, J. Vuorenmaa

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15 Citations (Scopus)

Abstract

The aim of this study was to examine whether yeast derivative (YD) based on brewery yeast hydrolyzate added to a post-weaning diet affected performance and immune responses in weaning pigs. One hundred and twenty pigs were allocated to 20 pens, taking initial body weight into account, and were distributed into two groups as follows: a negative control diet and the same diet supplemented with 2 g YD/kg. The YD used was Progut® (Hankkija Oy/Suomen Rehu, Hyvinkää, Finland). At days 7 and 21 of the experiment, half of the piglets per group were challenged intramuscularly with 1 mL of a solution of 20% sheep red blood cells (SRBC) in sterile phosphate buffered saline (PBS). At days 0, 14, 21 and 28 of the experiment, blood samples from the challenged piglets were obtained and acute-phase proteins (Pig-MAP), natural antibodies of the IgM- and IgG-isotype binding to keyhole limpet hemocyanin (KLH), and agglutinating antibody titers to SRBC were measured. Yeast derivative inclusion improved feed conversion ratio (P=0.025) for the overall period, tended to increase IgG (P=0.087) and IgM (P=0.061) antibodies in serum-binding KLH, and increased (P=0.037) SRBC agglutination titers. Collectively, these data suggest that YD supplementation as 2 g Progut®/kg to weanling pigs triggered the immune system to a more responsive state without penalizing the animal performance which could potentially be beneficial for overcoming disease challenges. Piglets fed with 2 g Progut®/kg for 28 days after weaning also showed an improvement in feed conversion ratio.
Original languageEnglish
Pages (from-to)136-141
JournalAnimal Feed Science and Technology
Volume195
DOIs
Publication statusPublished - 2014

Fingerprint

piglets
weaning
immune response
yeasts
chemical derivatives
swine
erythrocytes
sheep
antibodies
feed conversion
diet
brewing industry
acute phase proteins
agglutination
animal performance
blood serum
weanlings
Finland
immune system
phosphates

Keywords

  • growth-performance
  • saccharomyces-cerevisiae
  • natural antibodies
  • weanling pigs
  • nutrient digestibility
  • weaned piglets
  • supplementation
  • polysaccharides
  • challenge
  • chickens

Cite this

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title = "Effects of inclusion of hydrolyzed yeast on the immune response and performance of piglets after weaning",
abstract = "The aim of this study was to examine whether yeast derivative (YD) based on brewery yeast hydrolyzate added to a post-weaning diet affected performance and immune responses in weaning pigs. One hundred and twenty pigs were allocated to 20 pens, taking initial body weight into account, and were distributed into two groups as follows: a negative control diet and the same diet supplemented with 2 g YD/kg. The YD used was Progut{\circledR} (Hankkija Oy/Suomen Rehu, Hyvink{\"a}{\"a}, Finland). At days 7 and 21 of the experiment, half of the piglets per group were challenged intramuscularly with 1 mL of a solution of 20{\%} sheep red blood cells (SRBC) in sterile phosphate buffered saline (PBS). At days 0, 14, 21 and 28 of the experiment, blood samples from the challenged piglets were obtained and acute-phase proteins (Pig-MAP), natural antibodies of the IgM- and IgG-isotype binding to keyhole limpet hemocyanin (KLH), and agglutinating antibody titers to SRBC were measured. Yeast derivative inclusion improved feed conversion ratio (P=0.025) for the overall period, tended to increase IgG (P=0.087) and IgM (P=0.061) antibodies in serum-binding KLH, and increased (P=0.037) SRBC agglutination titers. Collectively, these data suggest that YD supplementation as 2 g Progut{\circledR}/kg to weanling pigs triggered the immune system to a more responsive state without penalizing the animal performance which could potentially be beneficial for overcoming disease challenges. Piglets fed with 2 g Progut{\circledR}/kg for 28 days after weaning also showed an improvement in feed conversion ratio.",
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author = "F. Molist and {van Eerden}, E. and H.K. Parmentier and J. Vuorenmaa",
year = "2014",
doi = "10.1016/j.anifeedsci.2014.04.020",
language = "English",
volume = "195",
pages = "136--141",
journal = "Animal Feed Science and Technology",
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Effects of inclusion of hydrolyzed yeast on the immune response and performance of piglets after weaning. / Molist, F.; van Eerden, E.; Parmentier, H.K.; Vuorenmaa, J.

In: Animal Feed Science and Technology, Vol. 195, 2014, p. 136-141.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Effects of inclusion of hydrolyzed yeast on the immune response and performance of piglets after weaning

AU - Molist, F.

AU - van Eerden, E.

AU - Parmentier, H.K.

AU - Vuorenmaa, J.

PY - 2014

Y1 - 2014

N2 - The aim of this study was to examine whether yeast derivative (YD) based on brewery yeast hydrolyzate added to a post-weaning diet affected performance and immune responses in weaning pigs. One hundred and twenty pigs were allocated to 20 pens, taking initial body weight into account, and were distributed into two groups as follows: a negative control diet and the same diet supplemented with 2 g YD/kg. The YD used was Progut® (Hankkija Oy/Suomen Rehu, Hyvinkää, Finland). At days 7 and 21 of the experiment, half of the piglets per group were challenged intramuscularly with 1 mL of a solution of 20% sheep red blood cells (SRBC) in sterile phosphate buffered saline (PBS). At days 0, 14, 21 and 28 of the experiment, blood samples from the challenged piglets were obtained and acute-phase proteins (Pig-MAP), natural antibodies of the IgM- and IgG-isotype binding to keyhole limpet hemocyanin (KLH), and agglutinating antibody titers to SRBC were measured. Yeast derivative inclusion improved feed conversion ratio (P=0.025) for the overall period, tended to increase IgG (P=0.087) and IgM (P=0.061) antibodies in serum-binding KLH, and increased (P=0.037) SRBC agglutination titers. Collectively, these data suggest that YD supplementation as 2 g Progut®/kg to weanling pigs triggered the immune system to a more responsive state without penalizing the animal performance which could potentially be beneficial for overcoming disease challenges. Piglets fed with 2 g Progut®/kg for 28 days after weaning also showed an improvement in feed conversion ratio.

AB - The aim of this study was to examine whether yeast derivative (YD) based on brewery yeast hydrolyzate added to a post-weaning diet affected performance and immune responses in weaning pigs. One hundred and twenty pigs were allocated to 20 pens, taking initial body weight into account, and were distributed into two groups as follows: a negative control diet and the same diet supplemented with 2 g YD/kg. The YD used was Progut® (Hankkija Oy/Suomen Rehu, Hyvinkää, Finland). At days 7 and 21 of the experiment, half of the piglets per group were challenged intramuscularly with 1 mL of a solution of 20% sheep red blood cells (SRBC) in sterile phosphate buffered saline (PBS). At days 0, 14, 21 and 28 of the experiment, blood samples from the challenged piglets were obtained and acute-phase proteins (Pig-MAP), natural antibodies of the IgM- and IgG-isotype binding to keyhole limpet hemocyanin (KLH), and agglutinating antibody titers to SRBC were measured. Yeast derivative inclusion improved feed conversion ratio (P=0.025) for the overall period, tended to increase IgG (P=0.087) and IgM (P=0.061) antibodies in serum-binding KLH, and increased (P=0.037) SRBC agglutination titers. Collectively, these data suggest that YD supplementation as 2 g Progut®/kg to weanling pigs triggered the immune system to a more responsive state without penalizing the animal performance which could potentially be beneficial for overcoming disease challenges. Piglets fed with 2 g Progut®/kg for 28 days after weaning also showed an improvement in feed conversion ratio.

KW - growth-performance

KW - saccharomyces-cerevisiae

KW - natural antibodies

KW - weanling pigs

KW - nutrient digestibility

KW - weaned piglets

KW - supplementation

KW - polysaccharides

KW - challenge

KW - chickens

U2 - 10.1016/j.anifeedsci.2014.04.020

DO - 10.1016/j.anifeedsci.2014.04.020

M3 - Article

VL - 195

SP - 136

EP - 141

JO - Animal Feed Science and Technology

JF - Animal Feed Science and Technology

SN - 0377-8401

ER -