Effects of high dietary chicken protein on obesity development of rats fed high-fat diets

Shangxin Song; Yulin Gao; Tianlan Xia; Yefei Zhou; Guido J.E.J. Hooiveld; Michael Muller; Chunbao Li

doi:10.1016/j.jff.2023.105713

Effects of high dietary chicken protein on obesity development of rats fed high-fat diets

Shangxin Song^*, Yulin Gao, Tianlan Xia, Yefei Zhou, Guido J.E.J. Hooiveld, Michael Muller, Chunbao Li

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

1 Citation (Scopus)

Abstract

This study explored the effects of dietary chicken protein at high (HCK, 40 % E) or normal (CK, 20 % E) levels on obesity development of rats fed high-fat diets. Compared with the CK diet, the HCK diet reduced body weight gain (by 15 %), epididymal adipose tissue mass (by 18.4 %), and adipocyte size (by 18.8 %) significantly without affecting the food intake of rats. It also reduced blood insulin and glycosylated serum protein (GSP) significantly by 45.4 % and 14.3 %, respectively; however, the OGTT and HOMA-IR results were not different. The HCK diet downregulated EAT transcriptomics related to the biosynthesis of cholesterol, triglycerides, and fatty acids, which were highly correlated with the most downregulated hub genes, Insig1, Srebf2, Hmgcs1, and Fasn. Therefore, high dietary chicken protein content reduced body fat accumulation, blood insulin, and GSP, and downregulated EAT transcriptomics related to lipid biosynthesis in rats fed high-fat diets.

Original language	English
Article number	105713
Journal	Journal of Functional Foods
Volume	108
DOIs	https://doi.org/10.1016/j.jff.2023.105713
Publication status	Published - Sept 2023

Keywords

Blood insulin
Body fat accumulation
High meat protein diet
Lipid metabolism
Transcriptomics

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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https://edepot.wur.nl/637163Licence: CC BY-NC-ND

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@article{a21b476ebc6c44e7ac206c83af991342,

title = "Effects of high dietary chicken protein on obesity development of rats fed high-fat diets",

abstract = "This study explored the effects of dietary chicken protein at high (HCK, 40 % E) or normal (CK, 20 % E) levels on obesity development of rats fed high-fat diets. Compared with the CK diet, the HCK diet reduced body weight gain (by 15 %), epididymal adipose tissue mass (by 18.4 %), and adipocyte size (by 18.8 %) significantly without affecting the food intake of rats. It also reduced blood insulin and glycosylated serum protein (GSP) significantly by 45.4 % and 14.3 %, respectively; however, the OGTT and HOMA-IR results were not different. The HCK diet downregulated EAT transcriptomics related to the biosynthesis of cholesterol, triglycerides, and fatty acids, which were highly correlated with the most downregulated hub genes, Insig1, Srebf2, Hmgcs1, and Fasn. Therefore, high dietary chicken protein content reduced body fat accumulation, blood insulin, and GSP, and downregulated EAT transcriptomics related to lipid biosynthesis in rats fed high-fat diets.",

keywords = "Blood insulin, Body fat accumulation, High meat protein diet, Lipid metabolism, Transcriptomics",

author = "Shangxin Song and Yulin Gao and Tianlan Xia and Yefei Zhou and {J.E.J. Hooiveld}, Guido and Michael Muller and Chunbao Li",

year = "2023",

month = sep,

doi = "10.1016/j.jff.2023.105713",

language = "English",

volume = "108",

journal = "Journal of Functional Foods",

issn = "1756-4646",

publisher = "Elsevier",

}

TY - JOUR

T1 - Effects of high dietary chicken protein on obesity development of rats fed high-fat diets

AU - Song, Shangxin

AU - Gao, Yulin

AU - Xia, Tianlan

AU - Zhou, Yefei

AU - J.E.J. Hooiveld, Guido

AU - Muller, Michael

AU - Li, Chunbao

PY - 2023/9

Y1 - 2023/9

N2 - This study explored the effects of dietary chicken protein at high (HCK, 40 % E) or normal (CK, 20 % E) levels on obesity development of rats fed high-fat diets. Compared with the CK diet, the HCK diet reduced body weight gain (by 15 %), epididymal adipose tissue mass (by 18.4 %), and adipocyte size (by 18.8 %) significantly without affecting the food intake of rats. It also reduced blood insulin and glycosylated serum protein (GSP) significantly by 45.4 % and 14.3 %, respectively; however, the OGTT and HOMA-IR results were not different. The HCK diet downregulated EAT transcriptomics related to the biosynthesis of cholesterol, triglycerides, and fatty acids, which were highly correlated with the most downregulated hub genes, Insig1, Srebf2, Hmgcs1, and Fasn. Therefore, high dietary chicken protein content reduced body fat accumulation, blood insulin, and GSP, and downregulated EAT transcriptomics related to lipid biosynthesis in rats fed high-fat diets.

AB - This study explored the effects of dietary chicken protein at high (HCK, 40 % E) or normal (CK, 20 % E) levels on obesity development of rats fed high-fat diets. Compared with the CK diet, the HCK diet reduced body weight gain (by 15 %), epididymal adipose tissue mass (by 18.4 %), and adipocyte size (by 18.8 %) significantly without affecting the food intake of rats. It also reduced blood insulin and glycosylated serum protein (GSP) significantly by 45.4 % and 14.3 %, respectively; however, the OGTT and HOMA-IR results were not different. The HCK diet downregulated EAT transcriptomics related to the biosynthesis of cholesterol, triglycerides, and fatty acids, which were highly correlated with the most downregulated hub genes, Insig1, Srebf2, Hmgcs1, and Fasn. Therefore, high dietary chicken protein content reduced body fat accumulation, blood insulin, and GSP, and downregulated EAT transcriptomics related to lipid biosynthesis in rats fed high-fat diets.

KW - Blood insulin

KW - Body fat accumulation

KW - High meat protein diet

KW - Lipid metabolism

KW - Transcriptomics

U2 - 10.1016/j.jff.2023.105713

DO - 10.1016/j.jff.2023.105713

M3 - Article

AN - SCOPUS:85166960721

SN - 1756-4646

VL - 108

JO - Journal of Functional Foods

JF - Journal of Functional Foods

M1 - 105713

ER -

Effects of high dietary chicken protein on obesity development of rats fed high-fat diets

Abstract

Keywords

UN SDGs

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