Effects of genetic selection for milk yield on energy balance, levels of hormones, and metabolites in lactating cattle, and possible links to reduced fertility

R.F. Veerkamp, B. Beerda, T. van der Lende

Research output: Contribution to journalArticleAcademicpeer-review

123 Citations (Scopus)

Abstract

Selection for a higher milk yield increases metabolic load via a higher yield per se and/or via physiological processes that facilitate milk yield, and it is difficult to differentiate between these two. Here, we aim to identify important pathways that contribute to the reduction in fertility following selection for higher yield. The associations between milk yield and fertility may run via pleiotropic effects, i.e. via functional pathways (for example related to intake), or linkage of genes and may involve changes in levels of hormones and metabolites. A number of studies have investigated the effects of genetic merit for milk yield on fertility, feed intake, energy balance and levels of metabolic and fertility hormones or metabolites. Differences in genetic merit were associated with differences in: (1) feed intake; (2) energy balance; and (3) plasma levels especially of GH, IGF-I, prolactin, progesterone, insulin, glucose, NEFAs and ketones. In the discussion we focus on the possible roles that energy balance, the growth hormone axis, and glucose together with insulin may have in the reduced fertility that is associated with high yield. The overall conclusion is that many minor pathways probably contribute, but that reduced metabolic fuel availability, rather than direct effects of hormone concentrations, is an important cause of poorer fertility with increasing genetic merit. (C) 2003 Elsevier B.V. All rights reserved.
Original languageEnglish
Pages (from-to)257-275
JournalLivestock Production Science
Volume83
DOIs
Publication statusPublished - 2003

Fingerprint

Genetic Selection
genetic merit
energy balance
Fertility
milk yield
Milk
hormones
Hormones
metabolites
cattle
insulin
feed intake
glucose
insulin-like growth factor I
prolactin
ketones
Insulin
somatotropin
Physiological Phenomena
linkage (genetics)

Keywords

  • growth-factor-i
  • friesian dairy-cattle
  • messenger-ribonucleic-acid
  • bovine granulosa-cells
  • dry-matter intake
  • free fatty-acids
  • body condition
  • luteinizing-hormone
  • postpartum ovulation
  • ovarian activity

Cite this

@article{36b730ccaea44fdcbc98751c82dbe8b7,
title = "Effects of genetic selection for milk yield on energy balance, levels of hormones, and metabolites in lactating cattle, and possible links to reduced fertility",
abstract = "Selection for a higher milk yield increases metabolic load via a higher yield per se and/or via physiological processes that facilitate milk yield, and it is difficult to differentiate between these two. Here, we aim to identify important pathways that contribute to the reduction in fertility following selection for higher yield. The associations between milk yield and fertility may run via pleiotropic effects, i.e. via functional pathways (for example related to intake), or linkage of genes and may involve changes in levels of hormones and metabolites. A number of studies have investigated the effects of genetic merit for milk yield on fertility, feed intake, energy balance and levels of metabolic and fertility hormones or metabolites. Differences in genetic merit were associated with differences in: (1) feed intake; (2) energy balance; and (3) plasma levels especially of GH, IGF-I, prolactin, progesterone, insulin, glucose, NEFAs and ketones. In the discussion we focus on the possible roles that energy balance, the growth hormone axis, and glucose together with insulin may have in the reduced fertility that is associated with high yield. The overall conclusion is that many minor pathways probably contribute, but that reduced metabolic fuel availability, rather than direct effects of hormone concentrations, is an important cause of poorer fertility with increasing genetic merit. (C) 2003 Elsevier B.V. All rights reserved.",
keywords = "growth-factor-i, friesian dairy-cattle, messenger-ribonucleic-acid, bovine granulosa-cells, dry-matter intake, free fatty-acids, body condition, luteinizing-hormone, postpartum ovulation, ovarian activity",
author = "R.F. Veerkamp and B. Beerda and {van der Lende}, T.",
year = "2003",
doi = "10.1016/S0301-6226(03)00108-8",
language = "English",
volume = "83",
pages = "257--275",
journal = "Livestock Production Science",
issn = "0301-6226",
publisher = "Elsevier BV",

}

TY - JOUR

T1 - Effects of genetic selection for milk yield on energy balance, levels of hormones, and metabolites in lactating cattle, and possible links to reduced fertility

AU - Veerkamp, R.F.

AU - Beerda, B.

AU - van der Lende, T.

PY - 2003

Y1 - 2003

N2 - Selection for a higher milk yield increases metabolic load via a higher yield per se and/or via physiological processes that facilitate milk yield, and it is difficult to differentiate between these two. Here, we aim to identify important pathways that contribute to the reduction in fertility following selection for higher yield. The associations between milk yield and fertility may run via pleiotropic effects, i.e. via functional pathways (for example related to intake), or linkage of genes and may involve changes in levels of hormones and metabolites. A number of studies have investigated the effects of genetic merit for milk yield on fertility, feed intake, energy balance and levels of metabolic and fertility hormones or metabolites. Differences in genetic merit were associated with differences in: (1) feed intake; (2) energy balance; and (3) plasma levels especially of GH, IGF-I, prolactin, progesterone, insulin, glucose, NEFAs and ketones. In the discussion we focus on the possible roles that energy balance, the growth hormone axis, and glucose together with insulin may have in the reduced fertility that is associated with high yield. The overall conclusion is that many minor pathways probably contribute, but that reduced metabolic fuel availability, rather than direct effects of hormone concentrations, is an important cause of poorer fertility with increasing genetic merit. (C) 2003 Elsevier B.V. All rights reserved.

AB - Selection for a higher milk yield increases metabolic load via a higher yield per se and/or via physiological processes that facilitate milk yield, and it is difficult to differentiate between these two. Here, we aim to identify important pathways that contribute to the reduction in fertility following selection for higher yield. The associations between milk yield and fertility may run via pleiotropic effects, i.e. via functional pathways (for example related to intake), or linkage of genes and may involve changes in levels of hormones and metabolites. A number of studies have investigated the effects of genetic merit for milk yield on fertility, feed intake, energy balance and levels of metabolic and fertility hormones or metabolites. Differences in genetic merit were associated with differences in: (1) feed intake; (2) energy balance; and (3) plasma levels especially of GH, IGF-I, prolactin, progesterone, insulin, glucose, NEFAs and ketones. In the discussion we focus on the possible roles that energy balance, the growth hormone axis, and glucose together with insulin may have in the reduced fertility that is associated with high yield. The overall conclusion is that many minor pathways probably contribute, but that reduced metabolic fuel availability, rather than direct effects of hormone concentrations, is an important cause of poorer fertility with increasing genetic merit. (C) 2003 Elsevier B.V. All rights reserved.

KW - growth-factor-i

KW - friesian dairy-cattle

KW - messenger-ribonucleic-acid

KW - bovine granulosa-cells

KW - dry-matter intake

KW - free fatty-acids

KW - body condition

KW - luteinizing-hormone

KW - postpartum ovulation

KW - ovarian activity

U2 - 10.1016/S0301-6226(03)00108-8

DO - 10.1016/S0301-6226(03)00108-8

M3 - Article

VL - 83

SP - 257

EP - 275

JO - Livestock Production Science

JF - Livestock Production Science

SN - 0301-6226

ER -