Effects of fatty acids on gene expression : role of peroxisome proliferator-activated receptor alpha, liver X receptor alpha and sterol regulatory element-binding protein-1c

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Abstract

Dietary fatty acids have numerous effects on cellular function, many of which are achieved by altering the expression of genes. The present paper reviews recent data on the mechanisms by which fatty acids influence DNA transcription, and focus specifically on the importance of three transcription factors: peroxisome proliferator-activated receptor α; liver X receptor α; sterol regulatory element-binding protein 1c. These data indicate that fatty acids induce or inhibit the mRNA expression of a variety of different genes by acting both as agonists and as antagonists for nuclear hormone receptors.
Original languageEnglish
Pages (from-to)371-374
JournalProceedings of the Nutrition Society
Volume61
DOIs
Publication statusPublished - 2002

Keywords

  • Fatty acids
  • mRNA expression
  • Nuclear hormone receptors
  • Transcription factors

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