Effects of dissolved organic matter and nitrification on biodegradation of pharmaceuticals in aerobic enrichment cultures

Yujie He, Alette A.M. Langenhoff*, Rob N.J. Comans, Nora B. Sutton, Huub H.M. Rijnaarts

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

9 Citations (Scopus)

Abstract

Natural dissolved organic matter (DOM) and nitrification can play an important role in biodegradation of pharmaceutically active compounds (PhACs) in aerobic zones of constructed wetlands (CWs). This study used an enrichment culture originating from CW sediment to study the effect of DOM and nitrification on aerobic biodegradation of seven PhACs. The enriched culture degraded caffeine (CAF), metoprolol (MET), naproxen (NAP), and ibuprofen (IBP) with a consistent biodegradability order of CAF > MET > NAP > IBP. Biodegradation of propranolol, carbamazepine, and diclofenac was insignificant (<15%). CAF biodegradation was inhibited by the easily biodegradable DOM. Conversely, DOM enhanced biodegradation of MET, NAP, and IBP, potentially by contributing more biomass capable of degrading PhACs. Nitrification enhanced biodegradation of NAP and IBP and mineralization of the PhAC mixture as well as less biodegradable DOM, which may result from co-metabolism of ammonia oxidizing bacteria or enhanced heterotrophic microbial activity under nitrification. MET biodegradation was inhibited in the presence of nitrification. DOM and nitrification effects on PhAC biodegradation in CWs gained from this study can be used in strategies to improve CW operation, namely: designing hydraulic retention times based on the biodegradability order of specific PhACs; applying DOM amendment; and introducing consistent ammonium streams to increase removal of PhACs of interest.
Original languageEnglish
Pages (from-to)1335-1342
JournalScience of the Total Environment
Volume630
DOIs
Publication statusPublished - 15 Jul 2018

Fingerprint

Nitrification
Biodegradation
dissolved organic matter
Biological materials
Drug products
nitrification
biodegradation
drug
Naproxen
Metoprolol
Ibuprofen
Wetlands
constructed wetland
Caffeine
Pharmaceutical Preparations
Biodegradability
effect
Diclofenac
Carbamazepine
Ammonium Compounds

Keywords

  • Aerobic biodegradation
  • Constructed wetland
  • DOM
  • Microbial degradation preference
  • Nitrification
  • Pharmaceuticals

Cite this

@article{333a14e853564b2aa16ff238db073fbf,
title = "Effects of dissolved organic matter and nitrification on biodegradation of pharmaceuticals in aerobic enrichment cultures",
abstract = "Natural dissolved organic matter (DOM) and nitrification can play an important role in biodegradation of pharmaceutically active compounds (PhACs) in aerobic zones of constructed wetlands (CWs). This study used an enrichment culture originating from CW sediment to study the effect of DOM and nitrification on aerobic biodegradation of seven PhACs. The enriched culture degraded caffeine (CAF), metoprolol (MET), naproxen (NAP), and ibuprofen (IBP) with a consistent biodegradability order of CAF > MET > NAP > IBP. Biodegradation of propranolol, carbamazepine, and diclofenac was insignificant (<15{\%}). CAF biodegradation was inhibited by the easily biodegradable DOM. Conversely, DOM enhanced biodegradation of MET, NAP, and IBP, potentially by contributing more biomass capable of degrading PhACs. Nitrification enhanced biodegradation of NAP and IBP and mineralization of the PhAC mixture as well as less biodegradable DOM, which may result from co-metabolism of ammonia oxidizing bacteria or enhanced heterotrophic microbial activity under nitrification. MET biodegradation was inhibited in the presence of nitrification. DOM and nitrification effects on PhAC biodegradation in CWs gained from this study can be used in strategies to improve CW operation, namely: designing hydraulic retention times based on the biodegradability order of specific PhACs; applying DOM amendment; and introducing consistent ammonium streams to increase removal of PhACs of interest.",
keywords = "Aerobic biodegradation, Constructed wetland, DOM, Microbial degradation preference, Nitrification, Pharmaceuticals",
author = "Yujie He and Langenhoff, {Alette A.M.} and Comans, {Rob N.J.} and Sutton, {Nora B.} and Rijnaarts, {Huub H.M.}",
year = "2018",
month = "7",
day = "15",
doi = "10.1016/j.scitotenv.2018.02.180",
language = "English",
volume = "630",
pages = "1335--1342",
journal = "Science of the Total Environment",
issn = "0048-9697",
publisher = "Elsevier",

}

TY - JOUR

T1 - Effects of dissolved organic matter and nitrification on biodegradation of pharmaceuticals in aerobic enrichment cultures

AU - He, Yujie

AU - Langenhoff, Alette A.M.

AU - Comans, Rob N.J.

AU - Sutton, Nora B.

AU - Rijnaarts, Huub H.M.

PY - 2018/7/15

Y1 - 2018/7/15

N2 - Natural dissolved organic matter (DOM) and nitrification can play an important role in biodegradation of pharmaceutically active compounds (PhACs) in aerobic zones of constructed wetlands (CWs). This study used an enrichment culture originating from CW sediment to study the effect of DOM and nitrification on aerobic biodegradation of seven PhACs. The enriched culture degraded caffeine (CAF), metoprolol (MET), naproxen (NAP), and ibuprofen (IBP) with a consistent biodegradability order of CAF > MET > NAP > IBP. Biodegradation of propranolol, carbamazepine, and diclofenac was insignificant (<15%). CAF biodegradation was inhibited by the easily biodegradable DOM. Conversely, DOM enhanced biodegradation of MET, NAP, and IBP, potentially by contributing more biomass capable of degrading PhACs. Nitrification enhanced biodegradation of NAP and IBP and mineralization of the PhAC mixture as well as less biodegradable DOM, which may result from co-metabolism of ammonia oxidizing bacteria or enhanced heterotrophic microbial activity under nitrification. MET biodegradation was inhibited in the presence of nitrification. DOM and nitrification effects on PhAC biodegradation in CWs gained from this study can be used in strategies to improve CW operation, namely: designing hydraulic retention times based on the biodegradability order of specific PhACs; applying DOM amendment; and introducing consistent ammonium streams to increase removal of PhACs of interest.

AB - Natural dissolved organic matter (DOM) and nitrification can play an important role in biodegradation of pharmaceutically active compounds (PhACs) in aerobic zones of constructed wetlands (CWs). This study used an enrichment culture originating from CW sediment to study the effect of DOM and nitrification on aerobic biodegradation of seven PhACs. The enriched culture degraded caffeine (CAF), metoprolol (MET), naproxen (NAP), and ibuprofen (IBP) with a consistent biodegradability order of CAF > MET > NAP > IBP. Biodegradation of propranolol, carbamazepine, and diclofenac was insignificant (<15%). CAF biodegradation was inhibited by the easily biodegradable DOM. Conversely, DOM enhanced biodegradation of MET, NAP, and IBP, potentially by contributing more biomass capable of degrading PhACs. Nitrification enhanced biodegradation of NAP and IBP and mineralization of the PhAC mixture as well as less biodegradable DOM, which may result from co-metabolism of ammonia oxidizing bacteria or enhanced heterotrophic microbial activity under nitrification. MET biodegradation was inhibited in the presence of nitrification. DOM and nitrification effects on PhAC biodegradation in CWs gained from this study can be used in strategies to improve CW operation, namely: designing hydraulic retention times based on the biodegradability order of specific PhACs; applying DOM amendment; and introducing consistent ammonium streams to increase removal of PhACs of interest.

KW - Aerobic biodegradation

KW - Constructed wetland

KW - DOM

KW - Microbial degradation preference

KW - Nitrification

KW - Pharmaceuticals

U2 - 10.1016/j.scitotenv.2018.02.180

DO - 10.1016/j.scitotenv.2018.02.180

M3 - Article

VL - 630

SP - 1335

EP - 1342

JO - Science of the Total Environment

JF - Science of the Total Environment

SN - 0048-9697

ER -