Effects of black hoof medicinal mushroom, phellinus linteus (Agaricomycetes), polysaccharide extract in streptozotocin-induced diabetic rats

Mustafa Yamaç*, Melih Zeytinoğlu, Hakan Şentürk, Kazim Kartkaya, Göngör Kanbak, Gökhan Bayramoğlu, Ayşegül Oğlakci, Leo J.L.D. van Griensven

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

17 Citations (Scopus)

Abstract

In this article we report the healing effects of a Phellinus linteus fruiting body hot water extract (PLE) in streptozotocin (STZ)–induced diabetic rats. PLE was given before and after STZ. The preprotective, protective, and postprotective effects of PLE on STZ-induced oxidative stress were studied using biochemical (caspase 3 activity, cytosolic-to-lysosomal ratio of cathepsin B and L, DNA fragmentation levels), ordinary histological and immuno-his-tochemical investigation parameters. Following oral administration of PLE after STZ application, the serum glucose concentration significantly decreased up to 41.13% compared with the control group (P <0.05). The hypoglycemic potential of the PLE was further supported by an increase of insulin secretion in the islets of Langerhans. In addition, the number of cells in Langerhans islets increased by 45.89% when PLE was given after STZ application. On the other hand, the use of PLE before oxidative stress could not prevent the onset of diabetes. This is, to our knowledge, the first study of the effect of application time of orally administered Ph. linteus hot water extract on STZ-induced diabetes.

Original languageEnglish
Pages (from-to)301-311
JournalInternational Journal of Medicinal Mushrooms
Volume18
Issue number4
DOIs
Publication statusPublished - 2016

Keywords

  • Antidiabetic activity
  • Medicinal mushrooms
  • Phellinus linteus
  • Polysaccharide
  • Rat

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