Effect of the NU-AGE Diet on Cognitive Functioning in Older Adults: A Randomized Controlled Trial

Anna Marseglia, W. Xu, Laura Fratiglioni, Cristina Fabbri, A.M. Berendsen, Agata Bialecka-Debek, A. Jennings, Rachel Gillings, N. Meunier, E. Caumon, S. Fairweather-Tait, B. Pietruszka, C.P.G.M. de Groot, A. Santoro, Claudio Franceschi

Research output: Contribution to journalArticleAcademicpeer-review

6 Citations (Scopus)

Abstract

Background: Findings from animal and epidemiological research support the potential neuroprotective benefits from healthy diets. However, to establish diet-neuroprotective causal relations, evidence from dietary intervention studies is needed. NU-AGE is the first multicenter intervention assessing whether a diet targeting health in aging can counteract the age-related physiological changes in different organs, including the brain. In this study, we specifically investigated the effects of NU-AGE’s dietary intervention on age-related cognitive decline.
Materials and Methods: NU-AGE randomized trial (NCT01754012, clinicaltrials.gov) included 1279 relatively healthy older-adults, aged 65–79 years, from five European centers. Participants were randomly allocated into two groups: “control” (n = 638), following a habitual diet; and, “intervention” (n = 641), given individually tailored dietary advice (NU-AGE diet). Adherence to the NU-AGE diet was measured over follow-up, and categorized into tertiles (low, moderate, high). Cognitive function was ascertained at baseline and at 1-year follow-up with the Consortium to Establish a Registry for Alzheimer’s Disease (CERAD)-Neuropsychological Battery and five additional domain-specific single cognitive tests. The raw scores from the CERAD subtests [excluding the Mini-Mental State Examination (MMSE)] and the single tests were standardized into Z-scores. Global cognition (measured with MMSE and CERAD-total score), and five cognitive domains (perceptual speed, executive function, episodic
memory, verbal abilities, and constructional praxis) were created. Cognitive changes as a function of the intervention were analyzed with multivariable mixed-effects models.
Results: After the 1-year follow-up, 571 (89.1%) controls and 573 (89.8%) from
the intervention group participated in the post-intervention assessment. Both control and intervention groups showed improvements in global cognition and in all cognitive domains after 1 year, but differences in cognitive changes between the two groups were not statistically significant. However, participants with higher adherence to the NU-AGE diet showed statistically significant improvements in global cognition [b 0.20 (95%CI 0.004, 0.39), p-value = 0.046] and episodic memory [b 0.15 (95%CI 0.02, 0.28), p-value = 0.025] after 1 year, compared to those adults with lower adherence.
Discussion: High adherence to the culturally adapted, individually tailored, NU-AGE diet could slow down age-related cognitive decline, helping to prevent cognitive impairment and dementia.
LanguageEnglish
Article number349
JournalFrontiers in Physiology
Volume9
DOIs
Publication statusPublished - 4 Apr 2018

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Randomized Controlled Trials
Diet
Cognition
Registries
Alzheimer Disease
Control Groups
Aptitude
Episodic Memory
Executive Function
Dementia
Health
Brain
Cognitive Dysfunction

Cite this

Marseglia, Anna ; Xu, W. ; Fratiglioni, Laura ; Fabbri, Cristina ; Berendsen, A.M. ; Bialecka-Debek, Agata ; Jennings, A. ; Gillings, Rachel ; Meunier, N. ; Caumon, E. ; Fairweather-Tait, S. ; Pietruszka, B. ; de Groot, C.P.G.M. ; Santoro, A. ; Franceschi, Claudio. / Effect of the NU-AGE Diet on Cognitive Functioning in Older Adults : A Randomized Controlled Trial. In: Frontiers in Physiology. 2018 ; Vol. 9.
@article{17b88ee0a8fe4bcaaca2ea218fd25b56,
title = "Effect of the NU-AGE Diet on Cognitive Functioning in Older Adults: A Randomized Controlled Trial",
abstract = "Background: Findings from animal and epidemiological research support the potential neuroprotective benefits from healthy diets. However, to establish diet-neuroprotective causal relations, evidence from dietary intervention studies is needed. NU-AGE is the first multicenter intervention assessing whether a diet targeting health in aging can counteract the age-related physiological changes in different organs, including the brain. In this study, we specifically investigated the effects of NU-AGE’s dietary intervention on age-related cognitive decline.Materials and Methods: NU-AGE randomized trial (NCT01754012, clinicaltrials.gov) included 1279 relatively healthy older-adults, aged 65–79 years, from five European centers. Participants were randomly allocated into two groups: “control” (n = 638), following a habitual diet; and, “intervention” (n = 641), given individually tailored dietary advice (NU-AGE diet). Adherence to the NU-AGE diet was measured over follow-up, and categorized into tertiles (low, moderate, high). Cognitive function was ascertained at baseline and at 1-year follow-up with the Consortium to Establish a Registry for Alzheimer’s Disease (CERAD)-Neuropsychological Battery and five additional domain-specific single cognitive tests. The raw scores from the CERAD subtests [excluding the Mini-Mental State Examination (MMSE)] and the single tests were standardized into Z-scores. Global cognition (measured with MMSE and CERAD-total score), and five cognitive domains (perceptual speed, executive function, episodicmemory, verbal abilities, and constructional praxis) were created. Cognitive changes as a function of the intervention were analyzed with multivariable mixed-effects models.Results: After the 1-year follow-up, 571 (89.1{\%}) controls and 573 (89.8{\%}) fromthe intervention group participated in the post-intervention assessment. Both control and intervention groups showed improvements in global cognition and in all cognitive domains after 1 year, but differences in cognitive changes between the two groups were not statistically significant. However, participants with higher adherence to the NU-AGE diet showed statistically significant improvements in global cognition [b 0.20 (95{\%}CI 0.004, 0.39), p-value = 0.046] and episodic memory [b 0.15 (95{\%}CI 0.02, 0.28), p-value = 0.025] after 1 year, compared to those adults with lower adherence.Discussion: High adherence to the culturally adapted, individually tailored, NU-AGE diet could slow down age-related cognitive decline, helping to prevent cognitive impairment and dementia.",
author = "Anna Marseglia and W. Xu and Laura Fratiglioni and Cristina Fabbri and A.M. Berendsen and Agata Bialecka-Debek and A. Jennings and Rachel Gillings and N. Meunier and E. Caumon and S. Fairweather-Tait and B. Pietruszka and {de Groot}, C.P.G.M. and A. Santoro and Claudio Franceschi",
year = "2018",
month = "4",
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doi = "10.3389/fphys.2018.00349",
language = "English",
volume = "9",
journal = "Frontiers in Physiology",
issn = "1664-042X",
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Marseglia, A, Xu, W, Fratiglioni, L, Fabbri, C, Berendsen, AM, Bialecka-Debek, A, Jennings, A, Gillings, R, Meunier, N, Caumon, E, Fairweather-Tait, S, Pietruszka, B, de Groot, CPGM, Santoro, A & Franceschi, C 2018, 'Effect of the NU-AGE Diet on Cognitive Functioning in Older Adults: A Randomized Controlled Trial', Frontiers in Physiology, vol. 9, 349. https://doi.org/10.3389/fphys.2018.00349

Effect of the NU-AGE Diet on Cognitive Functioning in Older Adults : A Randomized Controlled Trial. / Marseglia, Anna; Xu, W.; Fratiglioni, Laura; Fabbri, Cristina ; Berendsen, A.M.; Bialecka-Debek, Agata; Jennings, A.; Gillings, Rachel; Meunier, N.; Caumon, E.; Fairweather-Tait, S.; Pietruszka, B.; de Groot, C.P.G.M.; Santoro, A.; Franceschi, Claudio.

In: Frontiers in Physiology, Vol. 9, 349, 04.04.2018.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Effect of the NU-AGE Diet on Cognitive Functioning in Older Adults

T2 - Frontiers in Physiology

AU - Marseglia, Anna

AU - Xu, W.

AU - Fratiglioni, Laura

AU - Fabbri, Cristina

AU - Berendsen, A.M.

AU - Bialecka-Debek, Agata

AU - Jennings, A.

AU - Gillings, Rachel

AU - Meunier, N.

AU - Caumon, E.

AU - Fairweather-Tait, S.

AU - Pietruszka, B.

AU - de Groot, C.P.G.M.

AU - Santoro, A.

AU - Franceschi, Claudio

PY - 2018/4/4

Y1 - 2018/4/4

N2 - Background: Findings from animal and epidemiological research support the potential neuroprotective benefits from healthy diets. However, to establish diet-neuroprotective causal relations, evidence from dietary intervention studies is needed. NU-AGE is the first multicenter intervention assessing whether a diet targeting health in aging can counteract the age-related physiological changes in different organs, including the brain. In this study, we specifically investigated the effects of NU-AGE’s dietary intervention on age-related cognitive decline.Materials and Methods: NU-AGE randomized trial (NCT01754012, clinicaltrials.gov) included 1279 relatively healthy older-adults, aged 65–79 years, from five European centers. Participants were randomly allocated into two groups: “control” (n = 638), following a habitual diet; and, “intervention” (n = 641), given individually tailored dietary advice (NU-AGE diet). Adherence to the NU-AGE diet was measured over follow-up, and categorized into tertiles (low, moderate, high). Cognitive function was ascertained at baseline and at 1-year follow-up with the Consortium to Establish a Registry for Alzheimer’s Disease (CERAD)-Neuropsychological Battery and five additional domain-specific single cognitive tests. The raw scores from the CERAD subtests [excluding the Mini-Mental State Examination (MMSE)] and the single tests were standardized into Z-scores. Global cognition (measured with MMSE and CERAD-total score), and five cognitive domains (perceptual speed, executive function, episodicmemory, verbal abilities, and constructional praxis) were created. Cognitive changes as a function of the intervention were analyzed with multivariable mixed-effects models.Results: After the 1-year follow-up, 571 (89.1%) controls and 573 (89.8%) fromthe intervention group participated in the post-intervention assessment. Both control and intervention groups showed improvements in global cognition and in all cognitive domains after 1 year, but differences in cognitive changes between the two groups were not statistically significant. However, participants with higher adherence to the NU-AGE diet showed statistically significant improvements in global cognition [b 0.20 (95%CI 0.004, 0.39), p-value = 0.046] and episodic memory [b 0.15 (95%CI 0.02, 0.28), p-value = 0.025] after 1 year, compared to those adults with lower adherence.Discussion: High adherence to the culturally adapted, individually tailored, NU-AGE diet could slow down age-related cognitive decline, helping to prevent cognitive impairment and dementia.

AB - Background: Findings from animal and epidemiological research support the potential neuroprotective benefits from healthy diets. However, to establish diet-neuroprotective causal relations, evidence from dietary intervention studies is needed. NU-AGE is the first multicenter intervention assessing whether a diet targeting health in aging can counteract the age-related physiological changes in different organs, including the brain. In this study, we specifically investigated the effects of NU-AGE’s dietary intervention on age-related cognitive decline.Materials and Methods: NU-AGE randomized trial (NCT01754012, clinicaltrials.gov) included 1279 relatively healthy older-adults, aged 65–79 years, from five European centers. Participants were randomly allocated into two groups: “control” (n = 638), following a habitual diet; and, “intervention” (n = 641), given individually tailored dietary advice (NU-AGE diet). Adherence to the NU-AGE diet was measured over follow-up, and categorized into tertiles (low, moderate, high). Cognitive function was ascertained at baseline and at 1-year follow-up with the Consortium to Establish a Registry for Alzheimer’s Disease (CERAD)-Neuropsychological Battery and five additional domain-specific single cognitive tests. The raw scores from the CERAD subtests [excluding the Mini-Mental State Examination (MMSE)] and the single tests were standardized into Z-scores. Global cognition (measured with MMSE and CERAD-total score), and five cognitive domains (perceptual speed, executive function, episodicmemory, verbal abilities, and constructional praxis) were created. Cognitive changes as a function of the intervention were analyzed with multivariable mixed-effects models.Results: After the 1-year follow-up, 571 (89.1%) controls and 573 (89.8%) fromthe intervention group participated in the post-intervention assessment. Both control and intervention groups showed improvements in global cognition and in all cognitive domains after 1 year, but differences in cognitive changes between the two groups were not statistically significant. However, participants with higher adherence to the NU-AGE diet showed statistically significant improvements in global cognition [b 0.20 (95%CI 0.004, 0.39), p-value = 0.046] and episodic memory [b 0.15 (95%CI 0.02, 0.28), p-value = 0.025] after 1 year, compared to those adults with lower adherence.Discussion: High adherence to the culturally adapted, individually tailored, NU-AGE diet could slow down age-related cognitive decline, helping to prevent cognitive impairment and dementia.

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DO - 10.3389/fphys.2018.00349

M3 - Article

VL - 9

JO - Frontiers in Physiology

JF - Frontiers in Physiology

SN - 1664-042X

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ER -