Effect of the DGAT1 K232A polymorphism on milk-fat composition of dairy cows

A. Schennink, M.H.P.W. Visker, H. Bovenhuis, J.J. van der Poel, J.A.M. van Arendonk

Research output: Contribution to conferenceAbstractAcademic

Abstract

A Lys/Ala polymorphism in diacylglycerol acyltransferase 1 (DGAT1) is known to have a large effect on milk-fat percentage in dairy cows; it explains half of the genetic variation in milk-fat percentage. However, its effect on milk-fat composition has not been tested. We measured the fat composition of milk samples in 1,933 Dutch Holstein Friesian cows in their first lactation and genotyped the cows for the DGAT1 polymorphism. Statistical analysis confirmed the large effect of the DGAT1 polymorphism on milk-fat percentage: cows with the KK genotype have a milk-fat percentage of 5.0%, whereas cows with the AA genotype have a milk-fat percentage of 4.0%. The results revealed that this polymorphism has a clear influence on milk-fat composition as well. The A allele of DGAT1 is associated with less saturated fat; 7% smaller fraction of C16:0; and 7%, 10% and 13% larger fractions of C14:0, unsaturated C18, and CLAcis9, trans11. The polymorphism explains substantial proportions of the genetic variance: 53% for unsaturated C18, 40% for C16:0, 23% for C14:0 and 16% for CLAcis9, trans11. The results show that the DGAT1 polymorphism can be used as a marker in selective breeding to improve dairy quality
Original languageEnglish
Publication statusPublished - 2008
EventPlant and Animal Genome XVI -
Duration: 12 Jan 200816 Jan 2008

Conference

ConferencePlant and Animal Genome XVI
Period12/01/0816/01/08

Fingerprint

diacylglycerol acyltransferase
milk fat percentage
milk fat
dairy cows
genetic polymorphism
cows
genotype
selection methods
genetic variance
milk composition
dairies
statistical analysis
Holstein
lactation
alleles
genetic variation
lipids

Cite this

Schennink, A., Visker, M. H. P. W., Bovenhuis, H., van der Poel, J. J., & van Arendonk, J. A. M. (2008). Effect of the DGAT1 K232A polymorphism on milk-fat composition of dairy cows. Abstract from Plant and Animal Genome XVI, .
@conference{40b5cb7993c943eb90c9dea5c768f021,
title = "Effect of the DGAT1 K232A polymorphism on milk-fat composition of dairy cows",
abstract = "A Lys/Ala polymorphism in diacylglycerol acyltransferase 1 (DGAT1) is known to have a large effect on milk-fat percentage in dairy cows; it explains half of the genetic variation in milk-fat percentage. However, its effect on milk-fat composition has not been tested. We measured the fat composition of milk samples in 1,933 Dutch Holstein Friesian cows in their first lactation and genotyped the cows for the DGAT1 polymorphism. Statistical analysis confirmed the large effect of the DGAT1 polymorphism on milk-fat percentage: cows with the KK genotype have a milk-fat percentage of 5.0{\%}, whereas cows with the AA genotype have a milk-fat percentage of 4.0{\%}. The results revealed that this polymorphism has a clear influence on milk-fat composition as well. The A allele of DGAT1 is associated with less saturated fat; 7{\%} smaller fraction of C16:0; and 7{\%}, 10{\%} and 13{\%} larger fractions of C14:0, unsaturated C18, and CLAcis9, trans11. The polymorphism explains substantial proportions of the genetic variance: 53{\%} for unsaturated C18, 40{\%} for C16:0, 23{\%} for C14:0 and 16{\%} for CLAcis9, trans11. The results show that the DGAT1 polymorphism can be used as a marker in selective breeding to improve dairy quality",
author = "A. Schennink and M.H.P.W. Visker and H. Bovenhuis and {van der Poel}, J.J. and {van Arendonk}, J.A.M.",
year = "2008",
language = "English",
note = "Plant and Animal Genome XVI ; Conference date: 12-01-2008 Through 16-01-2008",

}

Schennink, A, Visker, MHPW, Bovenhuis, H, van der Poel, JJ & van Arendonk, JAM 2008, 'Effect of the DGAT1 K232A polymorphism on milk-fat composition of dairy cows' Plant and Animal Genome XVI, 12/01/08 - 16/01/08, .

Effect of the DGAT1 K232A polymorphism on milk-fat composition of dairy cows. / Schennink, A.; Visker, M.H.P.W.; Bovenhuis, H.; van der Poel, J.J.; van Arendonk, J.A.M.

2008. Abstract from Plant and Animal Genome XVI, .

Research output: Contribution to conferenceAbstractAcademic

TY - CONF

T1 - Effect of the DGAT1 K232A polymorphism on milk-fat composition of dairy cows

AU - Schennink, A.

AU - Visker, M.H.P.W.

AU - Bovenhuis, H.

AU - van der Poel, J.J.

AU - van Arendonk, J.A.M.

PY - 2008

Y1 - 2008

N2 - A Lys/Ala polymorphism in diacylglycerol acyltransferase 1 (DGAT1) is known to have a large effect on milk-fat percentage in dairy cows; it explains half of the genetic variation in milk-fat percentage. However, its effect on milk-fat composition has not been tested. We measured the fat composition of milk samples in 1,933 Dutch Holstein Friesian cows in their first lactation and genotyped the cows for the DGAT1 polymorphism. Statistical analysis confirmed the large effect of the DGAT1 polymorphism on milk-fat percentage: cows with the KK genotype have a milk-fat percentage of 5.0%, whereas cows with the AA genotype have a milk-fat percentage of 4.0%. The results revealed that this polymorphism has a clear influence on milk-fat composition as well. The A allele of DGAT1 is associated with less saturated fat; 7% smaller fraction of C16:0; and 7%, 10% and 13% larger fractions of C14:0, unsaturated C18, and CLAcis9, trans11. The polymorphism explains substantial proportions of the genetic variance: 53% for unsaturated C18, 40% for C16:0, 23% for C14:0 and 16% for CLAcis9, trans11. The results show that the DGAT1 polymorphism can be used as a marker in selective breeding to improve dairy quality

AB - A Lys/Ala polymorphism in diacylglycerol acyltransferase 1 (DGAT1) is known to have a large effect on milk-fat percentage in dairy cows; it explains half of the genetic variation in milk-fat percentage. However, its effect on milk-fat composition has not been tested. We measured the fat composition of milk samples in 1,933 Dutch Holstein Friesian cows in their first lactation and genotyped the cows for the DGAT1 polymorphism. Statistical analysis confirmed the large effect of the DGAT1 polymorphism on milk-fat percentage: cows with the KK genotype have a milk-fat percentage of 5.0%, whereas cows with the AA genotype have a milk-fat percentage of 4.0%. The results revealed that this polymorphism has a clear influence on milk-fat composition as well. The A allele of DGAT1 is associated with less saturated fat; 7% smaller fraction of C16:0; and 7%, 10% and 13% larger fractions of C14:0, unsaturated C18, and CLAcis9, trans11. The polymorphism explains substantial proportions of the genetic variance: 53% for unsaturated C18, 40% for C16:0, 23% for C14:0 and 16% for CLAcis9, trans11. The results show that the DGAT1 polymorphism can be used as a marker in selective breeding to improve dairy quality

M3 - Abstract

ER -

Schennink A, Visker MHPW, Bovenhuis H, van der Poel JJ, van Arendonk JAM. Effect of the DGAT1 K232A polymorphism on milk-fat composition of dairy cows. 2008. Abstract from Plant and Animal Genome XVI, .