Effect of Synbiotic on the Gut Microbiota of Cesarean Delivered Infants: A Randomized, Double-blind, Multicenter Study

Mei Chin Chua; Kaouther Ben-Amor; Christophe Lay; Anne G.E. Neo; Wei Chin Chiang; Rajeshwar Rao; Charmaine Chew; Surasith Chaithongwongwatthana; Nipon Khemapech; Jan Knol; Voranush Chongsrisawat

doi:10.1097/MPG.0000000000001623

Effect of Synbiotic on the Gut Microbiota of Cesarean Delivered Infants: A Randomized, Double-blind, Multicenter Study

Mei Chin Chua^*, Kaouther Ben-Amor, Christophe Lay, Anne G.E. Neo, Wei Chin Chiang, Rajeshwar Rao, Charmaine Chew, Surasith Chaithongwongwatthana, Nipon Khemapech, Jan Knol, Voranush Chongsrisawat

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

82 Citations (Scopus)

Abstract

We determined the effect of short-chain galacto-oligosaccharides (scGOS), long-chain fructo-oligosaccharides (lcFOS) and Bifidobacterium breve M-16V on the gut microbiota of cesarean-born infants. Infants were randomized to receive a standard formula (control), the same with scGOS/lcFOS and B. breve M-16V (synbiotic), or with scGOS/lcFOS (prebiotic) from birth until week 16, 30 subjects born vaginally were included as a reference group. Synbiotic supplementation resulted in a higher bifidobacteria proportion from day 3/5 (P<0.0001) until week 8 (P=0.041), a reduction of Enterobacteriaceae from day 3/5 (P=0.002) till week 12 (P=0.016) compared to controls. This was accompanied with a lower fecal pH and higher acetate. In the synbiotic group, B. breve M-16V was detected 6 weeks postintervention in 38.7% of the infants. This synbiotic concept supported the early modulation of Bifidobacterium in C-section born infants that was associated with the emulation of the gut physiological environment observed in vaginally delivered infants.

Original language	English
Pages (from-to)	102-106
Journal	Journal of Pediatric Gastroenterology and Nutrition
Volume	65
DOIs	https://doi.org/10.1097/MPG.0000000000001623
Publication status	Published - 2017

Keywords

Bifidobacterium breve M-16V
C-section
gut microbiota
prebiotics
probiotics
synbiotics

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10.1097/MPG.0000000000001623Licence: CC BY

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Chua, M. C., Ben-Amor, K., Lay, C., Neo, A. G. E., Chiang, W. C., Rao, R., Chew, C., Chaithongwongwatthana, S., Khemapech, N., Knol, J., & Chongsrisawat, V. (2017). Effect of Synbiotic on the Gut Microbiota of Cesarean Delivered Infants: A Randomized, Double-blind, Multicenter Study. Journal of Pediatric Gastroenterology and Nutrition, 65, 102-106. https://doi.org/10.1097/MPG.0000000000001623

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title = "Effect of Synbiotic on the Gut Microbiota of Cesarean Delivered Infants: A Randomized, Double-blind, Multicenter Study",

abstract = "We determined the effect of short-chain galacto-oligosaccharides (scGOS), long-chain fructo-oligosaccharides (lcFOS) and Bifidobacterium breve M-16V on the gut microbiota of cesarean-born infants. Infants were randomized to receive a standard formula (control), the same with scGOS/lcFOS and B. breve M-16V (synbiotic), or with scGOS/lcFOS (prebiotic) from birth until week 16, 30 subjects born vaginally were included as a reference group. Synbiotic supplementation resulted in a higher bifidobacteria proportion from day 3/5 (P<0.0001) until week 8 (P=0.041), a reduction of Enterobacteriaceae from day 3/5 (P=0.002) till week 12 (P=0.016) compared to controls. This was accompanied with a lower fecal pH and higher acetate. In the synbiotic group, B. breve M-16V was detected 6 weeks postintervention in 38.7% of the infants. This synbiotic concept supported the early modulation of Bifidobacterium in C-section born infants that was associated with the emulation of the gut physiological environment observed in vaginally delivered infants.",

keywords = "Bifidobacterium breve M-16V, C-section, gut microbiota, prebiotics, probiotics, synbiotics",

author = "Chua, {Mei Chin} and Kaouther Ben-Amor and Christophe Lay and Neo, {Anne G.E.} and Chiang, {Wei Chin} and Rajeshwar Rao and Charmaine Chew and Surasith Chaithongwongwatthana and Nipon Khemapech and Jan Knol and Voranush Chongsrisawat",

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doi = "10.1097/MPG.0000000000001623",

language = "English",

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Chua, MC, Ben-Amor, K, Lay, C, Neo, AGE, Chiang, WC, Rao, R, Chew, C, Chaithongwongwatthana, S, Khemapech, N, Knol, J & Chongsrisawat, V 2017, 'Effect of Synbiotic on the Gut Microbiota of Cesarean Delivered Infants: A Randomized, Double-blind, Multicenter Study', Journal of Pediatric Gastroenterology and Nutrition, vol. 65, pp. 102-106. https://doi.org/10.1097/MPG.0000000000001623

TY - JOUR

T1 - Effect of Synbiotic on the Gut Microbiota of Cesarean Delivered Infants

T2 - A Randomized, Double-blind, Multicenter Study

AU - Chua, Mei Chin

AU - Ben-Amor, Kaouther

AU - Lay, Christophe

AU - Neo, Anne G.E.

AU - Chiang, Wei Chin

AU - Rao, Rajeshwar

AU - Chew, Charmaine

AU - Chaithongwongwatthana, Surasith

AU - Khemapech, Nipon

AU - Knol, Jan

AU - Chongsrisawat, Voranush

PY - 2017

Y1 - 2017

N2 - We determined the effect of short-chain galacto-oligosaccharides (scGOS), long-chain fructo-oligosaccharides (lcFOS) and Bifidobacterium breve M-16V on the gut microbiota of cesarean-born infants. Infants were randomized to receive a standard formula (control), the same with scGOS/lcFOS and B. breve M-16V (synbiotic), or with scGOS/lcFOS (prebiotic) from birth until week 16, 30 subjects born vaginally were included as a reference group. Synbiotic supplementation resulted in a higher bifidobacteria proportion from day 3/5 (P<0.0001) until week 8 (P=0.041), a reduction of Enterobacteriaceae from day 3/5 (P=0.002) till week 12 (P=0.016) compared to controls. This was accompanied with a lower fecal pH and higher acetate. In the synbiotic group, B. breve M-16V was detected 6 weeks postintervention in 38.7% of the infants. This synbiotic concept supported the early modulation of Bifidobacterium in C-section born infants that was associated with the emulation of the gut physiological environment observed in vaginally delivered infants.

AB - We determined the effect of short-chain galacto-oligosaccharides (scGOS), long-chain fructo-oligosaccharides (lcFOS) and Bifidobacterium breve M-16V on the gut microbiota of cesarean-born infants. Infants were randomized to receive a standard formula (control), the same with scGOS/lcFOS and B. breve M-16V (synbiotic), or with scGOS/lcFOS (prebiotic) from birth until week 16, 30 subjects born vaginally were included as a reference group. Synbiotic supplementation resulted in a higher bifidobacteria proportion from day 3/5 (P<0.0001) until week 8 (P=0.041), a reduction of Enterobacteriaceae from day 3/5 (P=0.002) till week 12 (P=0.016) compared to controls. This was accompanied with a lower fecal pH and higher acetate. In the synbiotic group, B. breve M-16V was detected 6 weeks postintervention in 38.7% of the infants. This synbiotic concept supported the early modulation of Bifidobacterium in C-section born infants that was associated with the emulation of the gut physiological environment observed in vaginally delivered infants.

KW - Bifidobacterium breve M-16V

KW - C-section

KW - gut microbiota

KW - prebiotics

KW - probiotics

KW - synbiotics

U2 - 10.1097/MPG.0000000000001623

DO - 10.1097/MPG.0000000000001623

M3 - Article

AN - SCOPUS:85021802005

SN - 0277-2116

VL - 65

SP - 102

EP - 106

JO - Journal of Pediatric Gastroenterology and Nutrition

JF - Journal of Pediatric Gastroenterology and Nutrition

ER -

Effect of Synbiotic on the Gut Microbiota of Cesarean Delivered Infants: A Randomized, Double-blind, Multicenter Study

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Keywords

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