Effect of monounsaturated fatty acids on high-density and low-density lipoprotein cholesterol levels and blood pressure in healthy men and women

R.P. Mensink

Research output: Thesisinternal PhD, WU

Abstract

<TT>The purpose of the studies described in this thesis was to examine the effect of monounsaturated fatty acids on the distribution of serum cholesterol over high-density and low-density lipoproteins (HDL and LDL) and on blood pressure in healthy men and women. High levels of LDL cholesterol and blood pressure, and low levels of HDL cholesterol are associated with an increased risk for coronary heart disease.</TT><p><TT>Three controlled dietary studies were carried out. In the first study it was found that that monounsaturated fatty acids (oleic acid) specifically lowered non-HDL cholesterol when they replaced saturated fatty acids in the diet. In contrast, complex carbohydrates lowered both HDL and LDL cholesterol. The results of the second study indicated that it is immaterial whether saturated fatty acids in the diet are replaced by a mixture of monounsaturated and (n- 6)polyunsaturated fatty acids (oleic and linoleic acid) or by (n-6)polyunsaturated fatty acids alone. The two unsaturated-fat-rich diets had the same effect on HDL cholesterol and both lowered the level of LDL cholesterol to the same extent. In the third experiment we found that, when compared with <u>cis</u> monounsaturated fatty acids, <u>trans</u> monounsaturated fatty acids lower HDL cholesterol levels. In addition, <u>trans</u> fatty acids increased the level of LDL cholesterol, although to a lesser extent than did saturated fatty acids.</TT><p><TT>No effects of specific fatty acids on blood pressure were detected in any of the three experiments.</TT><p><TT>It is concluded that replacement of fats rich in saturated or <u>trans</u> fatty acids by oils rich oleic or linoleic acid might be helpful for the prevention of coronary heart disease, as far as lipoprotein levels are concerned. Weight gain, however, might be an unwanted side-effect of such high-oil diets.</TT><p><TT></TT>
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
Supervisors/Advisors
  • Hautvast, J.G.A.J., Promotor
  • Katan, M.B., Promotor
Award date23 Mar 1990
Place of PublicationS.l.
Publisher
Publication statusPublished - 1990

Keywords

  • blood lipids
  • lipoproteins
  • blood pressure
  • blood circulation
  • effects
  • oleic acid
  • unsaturated fatty acids
  • carboxylic acids
  • acrylic acid
  • nutrition
  • cholesterol

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