Effect of lowering of homocysteine levels on inflammatory markers : a randomized controlled trial

J. Durga, L.J.H. van Tits, E.G. Schouten, F.J. Kok, P. Verhoef

Research output: Contribution to journalArticleAcademicpeer-review

44 Citations (Scopus)

Abstract

Elevated concentrations of homocysteine and low concentrations of folate may lead to a proinflammatory state that could explain their relation to vascular disease risk. We investigated the effect of lowering homocysteine concentrations by means of folic acid supplementation on markers of inflammation. Methods: In a double-blind, randomized, placebo-controlled trial among 530 men and postmenopausal women with homocysteine concentrations of 1.8 mg/L or higher (¿13 ¿mol/L) at screening, we investigated the effect of folic acid supplementation (0.8 mg/d) vs placebo for 1 year on serum concentrations of C-reactive protein, soluble intercellular adhesion molecule-1, oxidized low-density lipoprotein, and autoantibodies against oxidized low-density lipoprotein. Results: After 1 year of supplementation, concentrations of serum folate increased by 400% (95% confidence interval [CI], 362%-436%), and those of homocysteine decreased by 28% (95% CI, 24%-36%) in the folic group compared with the placebo group. However, changes in plasma concentrations of the inflammatory markers were observed. Conclusions: Although homocysteine is associated with vascular disease risk in the general population, marked lowering of slightly elevated homocysteine concentrations by means of 1-year folic acid supplementation does influence inflammatory responses involving C-reactive protein, soluble intercellular adhesion molecule-1, oxidized low-density lipoprotein, and autoantibodies against oxidized low-density lipoprotein.
Original languageEnglish
Pages (from-to)1388-1394
JournalArchives of Internal Medicine
Volume165
Issue number12
DOIs
Publication statusPublished - 2005

Keywords

  • intercellular-adhesion molecule-1
  • coronary-artery-disease
  • low-density-lipoprotein
  • placebo-controlled trial
  • acid plus vitamin-b-6
  • c-reactive protein
  • folic-acid
  • myocardial-infarction
  • oxidized ldl
  • induced hyperhomocysteinemia

Fingerprint Dive into the research topics of 'Effect of lowering of homocysteine levels on inflammatory markers : a randomized controlled trial'. Together they form a unique fingerprint.

Cite this