Effect of H7N1 vaccination on highly pathogenic avian influenza H7N7 virus transmission in turkeys

M.E.H. Bos; M. Nielen; G. Koch; A. Stegeman; M.C.M. de Jong

doi:10.1016/j.vaccine.2008.09.022

Effect of H7N1 vaccination on highly pathogenic avian influenza H7N7 virus transmission in turkeys

M.E.H. Bos, M. Nielen, G. Koch, A. Stegeman, M.C.M. de Jong

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

This study describes the results of a transmission experiment with highly pathogenic avian influenza (HPAI) H7N7 virus in 12-week-old turkeys. Cloacal and tracheal swabs as well as serum samples were taken to monitor the infection both in inoculated and in susceptible contact turkeys, which were all either unvaccinated, vaccinated once or vaccinated twice with H7N1. Swabs were tested by real-time RT-PCR and serum samples with hemagglutination inhibition test (HI). Unvaccinated contact birds had a mean infectious period of 6.2 days, and an estimated transmission rate parameter of 1.26 per infectious bird per day. However, no virus shedding was found in inoculated vaccinated turkeys and thus we concluded that vaccination with H7N1 protected against challenge with HPAI H7N7 virus.

Original language	English
Pages (from-to)	6322-6328
Journal	Vaccine
Volume	26
Issue number	50
DOIs	https://doi.org/10.1016/j.vaccine.2008.09.022
Publication status	Published - 2008

Keywords

infection
chickens
susceptibility
patterns
efficacy
h5

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.vaccine.2008.09.022

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title = "Effect of H7N1 vaccination on highly pathogenic avian influenza H7N7 virus transmission in turkeys",

abstract = "This study describes the results of a transmission experiment with highly pathogenic avian influenza (HPAI) H7N7 virus in 12-week-old turkeys. Cloacal and tracheal swabs as well as serum samples were taken to monitor the infection both in inoculated and in susceptible contact turkeys, which were all either unvaccinated, vaccinated once or vaccinated twice with H7N1. Swabs were tested by real-time RT-PCR and serum samples with hemagglutination inhibition test (HI). Unvaccinated contact birds had a mean infectious period of 6.2 days, and an estimated transmission rate parameter of 1.26 per infectious bird per day. However, no virus shedding was found in inoculated vaccinated turkeys and thus we concluded that vaccination with H7N1 protected against challenge with HPAI H7N7 virus.",

keywords = "infection, chickens, susceptibility, patterns, efficacy, h5",

author = "M.E.H. Bos and M. Nielen and G. Koch and A. Stegeman and {de Jong}, M.C.M.",

year = "2008",

doi = "10.1016/j.vaccine.2008.09.022",

language = "English",

volume = "26",

pages = "6322--6328",

journal = "Vaccine",

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number = "50",

}

TY - JOUR

T1 - Effect of H7N1 vaccination on highly pathogenic avian influenza H7N7 virus transmission in turkeys

AU - Bos, M.E.H.

AU - Nielen, M.

AU - Koch, G.

AU - Stegeman, A.

AU - de Jong, M.C.M.

PY - 2008

Y1 - 2008

N2 - This study describes the results of a transmission experiment with highly pathogenic avian influenza (HPAI) H7N7 virus in 12-week-old turkeys. Cloacal and tracheal swabs as well as serum samples were taken to monitor the infection both in inoculated and in susceptible contact turkeys, which were all either unvaccinated, vaccinated once or vaccinated twice with H7N1. Swabs were tested by real-time RT-PCR and serum samples with hemagglutination inhibition test (HI). Unvaccinated contact birds had a mean infectious period of 6.2 days, and an estimated transmission rate parameter of 1.26 per infectious bird per day. However, no virus shedding was found in inoculated vaccinated turkeys and thus we concluded that vaccination with H7N1 protected against challenge with HPAI H7N7 virus.

AB - This study describes the results of a transmission experiment with highly pathogenic avian influenza (HPAI) H7N7 virus in 12-week-old turkeys. Cloacal and tracheal swabs as well as serum samples were taken to monitor the infection both in inoculated and in susceptible contact turkeys, which were all either unvaccinated, vaccinated once or vaccinated twice with H7N1. Swabs were tested by real-time RT-PCR and serum samples with hemagglutination inhibition test (HI). Unvaccinated contact birds had a mean infectious period of 6.2 days, and an estimated transmission rate parameter of 1.26 per infectious bird per day. However, no virus shedding was found in inoculated vaccinated turkeys and thus we concluded that vaccination with H7N1 protected against challenge with HPAI H7N7 virus.

KW - infection

KW - chickens

KW - susceptibility

KW - patterns

KW - efficacy

KW - h5

U2 - 10.1016/j.vaccine.2008.09.022

DO - 10.1016/j.vaccine.2008.09.022

M3 - Article

SN - 0264-410X

VL - 26

SP - 6322

EP - 6328

JO - Vaccine

JF - Vaccine

IS - 50

ER -

Effect of H7N1 vaccination on highly pathogenic avian influenza H7N7 virus transmission in turkeys

Abstract

Keywords

UN SDGs

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