Effect of antenatal zinc supplementation on impetigo in infants in Bangladesh

G.L. Darmstadt, S.J.M. Osendarp, S. Ahmed, C. Feldman, J.M.A. van Raaij, A.H. Baqui, J.G.A.J. Hautvast, G.J. Fuchs

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We sought to determine the effects of maternal zinc supplementation on skin infections among infants in poor urban areas of Dhaka, Bangladesh. A double-blind, placebo-controlled, randomized trial was conducted among 199 and 221 Bangladeshi infants whose mothers were administered 30 mg daily of zinc or placebo, respectively. The mothers received zinc supplementation from 12-16 weeks' gestation until delivery, and the infants were followed up until 6 months of age. Among the infants of mothers who received zinc supplementation during the antenatal period, 10.6% had at least 1 episode of impetigo compared with 19.6% of the infants of mothers in the placebo group (P = 0.01). Infants in the treatment group had a 54% reduction in incidence rate of episodes of impetigo when compared with infants in the placebo group (P = 0.01). The effect of zinc supplementation was more pronounced among male infants (64% reduction) and intrauterine growth restricted and low birth weight infants (73% reduction) and among infants of mothers with increased parity (60% reduction) or decreased socioeconomic status (71% reduction).
Original languageEnglish
Pages (from-to)407-409
JournalThe Pediatric Infectious Disease Journal
Issue number4
Publication statusPublished - 2012



  • placebo-controlled trial
  • birth-weight infants
  • pregnancy
  • growth

Cite this

Darmstadt, G. L., Osendarp, S. J. M., Ahmed, S., Feldman, C., van Raaij, J. M. A., Baqui, A. H., ... Fuchs, G. J. (2012). Effect of antenatal zinc supplementation on impetigo in infants in Bangladesh. The Pediatric Infectious Disease Journal, 31(4), 407-409. https://doi.org/10.1097/INF.0b013e318243e232