Effect of antenatal zinc supplementation on impetigo in infants in Bangladesh

G.L. Darmstadt, S.J.M. Osendarp, S. Ahmed, C. Feldman, J.M.A. van Raaij, A.H. Baqui, J.G.A.J. Hautvast, G.J. Fuchs

Research output: Contribution to journalArticleAcademicpeer-review

5 Citations (Scopus)

Abstract

We sought to determine the effects of maternal zinc supplementation on skin infections among infants in poor urban areas of Dhaka, Bangladesh. A double-blind, placebo-controlled, randomized trial was conducted among 199 and 221 Bangladeshi infants whose mothers were administered 30 mg daily of zinc or placebo, respectively. The mothers received zinc supplementation from 12-16 weeks' gestation until delivery, and the infants were followed up until 6 months of age. Among the infants of mothers who received zinc supplementation during the antenatal period, 10.6% had at least 1 episode of impetigo compared with 19.6% of the infants of mothers in the placebo group (P = 0.01). Infants in the treatment group had a 54% reduction in incidence rate of episodes of impetigo when compared with infants in the placebo group (P = 0.01). The effect of zinc supplementation was more pronounced among male infants (64% reduction) and intrauterine growth restricted and low birth weight infants (73% reduction) and among infants of mothers with increased parity (60% reduction) or decreased socioeconomic status (71% reduction).
Original languageEnglish
Pages (from-to)407-409
JournalThe Pediatric Infectious Disease Journal
Volume31
Issue number4
DOIs
Publication statusPublished - 2012

Keywords

  • placebo-controlled trial
  • birth-weight infants
  • pregnancy
  • growth

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