Effect of a TLR1A polymorphism on natural antibodies in poultry

H. Bovenhuis; T.V.L. Berghof; M.H.P.W. Visker; J.A.J. Arts; J. Visscher; J.J. van der Poel; H.K. Parmentier

doi:10.3920/978-90-8686-940-4_815

Effect of a TLR1A polymorphism on natural antibodies in poultry

H. Bovenhuis, T.V.L. Berghof, M.H.P.W. Visker, J.A.J. Arts, J. Visscher, J.J. van der Poel, H.K. Parmentier

Research output: Chapter in Book/Report/Conference proceeding › Conference paper › Academic

Abstract

The aim of the current study was to confirm and characterise the effect of a polymorphism in the Toll-like receptor 1 family member A (TLR1A) gene on levels of natural antibodies (NAb) in poultry. The study population consisted of a base population and 7 generations of birds from a High and Low selection line. Genotypes for a polymorphism in TLR1A were available for chickens in generations 5, 6 and 7. The TLR1A polymorphism had large and significant effects on total NAb levels (IgTotal) and IgM NAb, with full dominance of the TLR1A C allele. Significant (TLR1A*Generation) interactions were detected for IgM and IgTotal. The frequency of the TLR1A C allele was 0.45 in the base population (based on imputed genotypes), 0.66 and 0.04 in generation 7 of the High and Low line, respectively. Results confirm the major effect of this polymorphism in TLR1A on NAb levels suggest high sensitivity of the effect to environmental factors.

Original language	English
Title of host publication	Proceedings of 12th World Congress on Genetics Applied to Livestock Production (WCGALP)
Subtitle of host publication	Technical and species orientated innovations in animal breeding, and contribution of genetics to solving societal challenges
Editors	R.F. Veerkamp, Y. de Haas
Place of Publication	Wageningen
Publisher	Wageningen Academic Publishers
Pages	3355-3359
Number of pages	4
ISBN (Electronic)	9789086869404
DOIs	https://doi.org/10.3920/978-90-8686-940-4_815
Publication status	Published - 2022
Event	World Congress on Genetics Applied to Livestock Production: WCGALP 2022 - Rotterdam, Netherlands Duration: 3 Jul 2022 → 8 Jul 2022

Conference

Conference	World Congress on Genetics Applied to Livestock Production: WCGALP 2022
Country/Territory	Netherlands
City	Rotterdam
Period	3/07/22 → 8/07/22

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10.3920/978-90-8686-940-4_815Licence: CC BY

https://edepot.wur.nl/585044Licence: CC BY

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Bovenhuis, H., Berghof, T. V. L., Visker, M. H. P. W., Arts, J. A. J., Visscher, J., van der Poel, J. J., & Parmentier, H. K. (2022). Effect of a TLR1A polymorphism on natural antibodies in poultry. In R. F. Veerkamp, & Y. de Haas (Eds.), Proceedings of 12th World Congress on Genetics Applied to Livestock Production (WCGALP): Technical and species orientated innovations in animal breeding, and contribution of genetics to solving societal challenges (pp. 3355-3359). [815] Wageningen Academic Publishers. https://doi.org/10.3920/978-90-8686-940-4_815

Bovenhuis, H. ; Berghof, T.V.L. ; Visker, M.H.P.W. et al. / Effect of a TLR1A polymorphism on natural antibodies in poultry. Proceedings of 12th World Congress on Genetics Applied to Livestock Production (WCGALP): Technical and species orientated innovations in animal breeding, and contribution of genetics to solving societal challenges. editor / R.F. Veerkamp ; Y. de Haas. Wageningen : Wageningen Academic Publishers, 2022. pp. 3355-3359

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title = "Effect of a TLR1A polymorphism on natural antibodies in poultry",

abstract = "The aim of the current study was to confirm and characterise the effect of a polymorphism in the Toll-like receptor 1 family member A (TLR1A) gene on levels of natural antibodies (NAb) in poultry. The study population consisted of a base population and 7 generations of birds from a High and Low selection line. Genotypes for a polymorphism in TLR1A were available for chickens in generations 5, 6 and 7. The TLR1A polymorphism had large and significant effects on total NAb levels (IgTotal) and IgM NAb, with full dominance of the TLR1A C allele. Significant (TLR1A*Generation) interactions were detected for IgM and IgTotal. The frequency of the TLR1A C allele was 0.45 in the base population (based on imputed genotypes), 0.66 and 0.04 in generation 7 of the High and Low line, respectively. Results confirm the major effect of this polymorphism in TLR1A on NAb levels suggest high sensitivity of the effect to environmental factors.",

author = "H. Bovenhuis and T.V.L. Berghof and M.H.P.W. Visker and J.A.J. Arts and J. Visscher and {van der Poel}, J.J. and H.K. Parmentier",

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doi = "10.3920/978-90-8686-940-4_815",

language = "English",

pages = "3355--3359",

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booktitle = "Proceedings of 12th World Congress on Genetics Applied to Livestock Production (WCGALP)",

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Bovenhuis, H, Berghof, TVL, Visker, MHPW, Arts, JAJ, Visscher, J, van der Poel, JJ & Parmentier, HK 2022, Effect of a TLR1A polymorphism on natural antibodies in poultry. in RF Veerkamp & Y de Haas (eds), Proceedings of 12th World Congress on Genetics Applied to Livestock Production (WCGALP): Technical and species orientated innovations in animal breeding, and contribution of genetics to solving societal challenges., 815, Wageningen Academic Publishers, Wageningen, pp. 3355-3359, World Congress on Genetics Applied to Livestock Production: WCGALP 2022, Rotterdam, Netherlands, 3/07/22. https://doi.org/10.3920/978-90-8686-940-4_815

Effect of a TLR1A polymorphism on natural antibodies in poultry. / Bovenhuis, H.; Berghof, T.V.L.; Visker, M.H.P.W. et al.

Proceedings of 12th World Congress on Genetics Applied to Livestock Production (WCGALP): Technical and species orientated innovations in animal breeding, and contribution of genetics to solving societal challenges. ed. / R.F. Veerkamp; Y. de Haas. Wageningen : Wageningen Academic Publishers, 2022. p. 3355-3359 815.

Research output: Chapter in Book/Report/Conference proceeding › Conference paper › Academic

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T1 - Effect of a TLR1A polymorphism on natural antibodies in poultry

AU - Bovenhuis, H.

AU - Berghof, T.V.L.

AU - Visker, M.H.P.W.

AU - Arts, J.A.J.

AU - Visscher, J.

AU - van der Poel, J.J.

AU - Parmentier, H.K.

PY - 2022

Y1 - 2022

N2 - The aim of the current study was to confirm and characterise the effect of a polymorphism in the Toll-like receptor 1 family member A (TLR1A) gene on levels of natural antibodies (NAb) in poultry. The study population consisted of a base population and 7 generations of birds from a High and Low selection line. Genotypes for a polymorphism in TLR1A were available for chickens in generations 5, 6 and 7. The TLR1A polymorphism had large and significant effects on total NAb levels (IgTotal) and IgM NAb, with full dominance of the TLR1A C allele. Significant (TLR1A*Generation) interactions were detected for IgM and IgTotal. The frequency of the TLR1A C allele was 0.45 in the base population (based on imputed genotypes), 0.66 and 0.04 in generation 7 of the High and Low line, respectively. Results confirm the major effect of this polymorphism in TLR1A on NAb levels suggest high sensitivity of the effect to environmental factors.

AB - The aim of the current study was to confirm and characterise the effect of a polymorphism in the Toll-like receptor 1 family member A (TLR1A) gene on levels of natural antibodies (NAb) in poultry. The study population consisted of a base population and 7 generations of birds from a High and Low selection line. Genotypes for a polymorphism in TLR1A were available for chickens in generations 5, 6 and 7. The TLR1A polymorphism had large and significant effects on total NAb levels (IgTotal) and IgM NAb, with full dominance of the TLR1A C allele. Significant (TLR1A*Generation) interactions were detected for IgM and IgTotal. The frequency of the TLR1A C allele was 0.45 in the base population (based on imputed genotypes), 0.66 and 0.04 in generation 7 of the High and Low line, respectively. Results confirm the major effect of this polymorphism in TLR1A on NAb levels suggest high sensitivity of the effect to environmental factors.

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DO - 10.3920/978-90-8686-940-4_815

M3 - Conference paper

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EP - 3359

BT - Proceedings of 12th World Congress on Genetics Applied to Livestock Production (WCGALP)

A2 - Veerkamp, R.F.

A2 - de Haas, Y.

PB - Wageningen Academic Publishers

CY - Wageningen

T2 - World Congress on Genetics Applied to Livestock Production: WCGALP 2022

Y2 - 3 July 2022 through 8 July 2022

ER -

Bovenhuis H, Berghof TVL, Visker MHPW, Arts JAJ, Visscher J, van der Poel JJ et al. Effect of a TLR1A polymorphism on natural antibodies in poultry. In Veerkamp RF, de Haas Y, editors, Proceedings of 12th World Congress on Genetics Applied to Livestock Production (WCGALP): Technical and species orientated innovations in animal breeding, and contribution of genetics to solving societal challenges. Wageningen: Wageningen Academic Publishers. 2022. p. 3355-3359. 815 doi: 10.3920/978-90-8686-940-4_815

Effect of a TLR1A polymorphism on natural antibodies in poultry

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