Effect of a TLR1A polymorphism on natural antibodies in poultry

H. Bovenhuis, T.V.L. Berghof, M.H.P.W. Visker, J.A.J. Arts, J. Visscher, J.J. van der Poel, H.K. Parmentier

Research output: Chapter in Book/Report/Conference proceedingConference paperAcademic


The aim of the current study was to confirm and characterise the effect of a polymorphism in the Toll-like receptor 1 family member A (TLR1A) gene on levels of natural antibodies (NAb) in poultry. The study population consisted of a base population and 7 generations of birds from a High and Low selection line. Genotypes for a polymorphism in TLR1A were available for chickens in generations 5, 6 and 7. The TLR1A polymorphism had large and significant effects on total NAb levels (IgTotal) and IgM NAb, with full dominance of the TLR1A C allele. Significant (TLR1A*Generation) interactions were detected for IgM and IgTotal. The frequency of the TLR1A C allele was 0.45 in the base population (based on imputed genotypes), 0.66 and 0.04 in generation 7 of the High and Low line, respectively. Results confirm the major effect of this polymorphism in TLR1A on NAb levels suggest high sensitivity of the effect to environmental factors.
Original languageEnglish
Title of host publicationProceedings of 12th World Congress on Genetics Applied to Livestock Production (WCGALP)
Subtitle of host publicationTechnical and species orientated innovations in animal breeding, and contribution of genetics to solving societal challenges
EditorsR.F. Veerkamp, Y. de Haas
Place of PublicationWageningen
PublisherWageningen Academic Publishers
Number of pages4
ISBN (Electronic)9789086869404
Publication statusPublished - 2022
EventWorld Congress on Genetics Applied to Livestock Production: WCGALP 2022 - Rotterdam, Netherlands
Duration: 3 Jul 20228 Jul 2022


ConferenceWorld Congress on Genetics Applied to Livestock Production: WCGALP 2022


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