Effect of a high monounsaturated fatty acids diet and a Mediterranean diet on serum lipids and insulin sensitivity in adults with mild abdominal obesity

M.B. Bos, J.H.M. de Vries, E.J.M. Feskens, S.J. van Dijk, D. Hoelen, E. Siebelink, R. Heijligenberg, C.P.G.M. de Groot

Research output: Contribution to journalArticleAcademicpeer-review

77 Citations (Scopus)

Abstract

Background and aims - Diets high in monounsaturated fatty acids (MUFA) such as a Mediterranean diet may reduce the risk of cardiovascular diseases by improving insulin sensitivity and serum lipids. Besides being high in MUFA, a Mediterranean diet also contains abundant plant foods, moderate wine and low amounts of meat and dairy products, which may also play a role. We compared the effects of a high MUFA-diet with a diet high in saturated fatty acids (SFA) and the additional effect of a Mediterranean diet on insulin sensitivity and serum lipids. Methods and results - A randomized parallel controlled-feeding trial was performed, in 60 non-diabetics (40–65 y) with mild abdominal obesity. After a two week run-in diet high in SFA (19 energy-%), subjects were allocated to a high MUFA-diet (20 energy-%), a Mediterranean diet (MUFA 21 energy-%), or the high SFA-diet, for eight weeks. The high MUFA and the Mediterranean diet did not affect fasting insulin concentrations. The high MUFA-diet reduced total cholesterol (-0.41 mmol/L, 95% CI -0.74, -0.09) and LDL-cholesterol (-0.38 mmol/L, 95% CI -0.65, -0.11) compared with the high SFA-diet, but not triglyceride concentrations. The Mediterranean diet increased HDL-cholesterol concentrations (+0.09 mmol/L, 95% CI 0.0, 0.18) and reduced the ratio of total cholesterol/HDL-cholesterol (-0.39, 95% CI -0.62, -0.16) compared with the high MUFA-diet. Conclusion - Replacing a high SFA-diet with a high MUFA or a Mediterranean diet did not affect insulin sensitivity, but improved serum lipids. The Mediterranean diet was most effective, it reduced total and LDL-cholesterol, and also increased HDL-cholesterol and reduced total cholesterol/HDL-cholesterol ratio.
Original languageEnglish
Pages (from-to)591-598
JournalNutrition, Metabolism & Cardiovascular Diseases
Volume20
Issue number8
DOIs
Publication statusPublished - 2010

Keywords

  • glucose-tolerance
  • controlled-trials
  • randomized-trial
  • heart-disease
  • risk-factors
  • healthy-men
  • cholesterol
  • metaanalysis
  • resistance
  • determinants

Fingerprint Dive into the research topics of 'Effect of a high monounsaturated fatty acids diet and a Mediterranean diet on serum lipids and insulin sensitivity in adults with mild abdominal obesity'. Together they form a unique fingerprint.

Cite this