Effect of a High Intake of Conjugated Linoleic Acid on Lipoprotein Levels in Healthy Human Subjects

A.J. Wanders, I.A. Brouwer, E. Siebelink, M.B. Katan

Research output: Contribution to journalArticleAcademicpeer-review

56 Citations (Scopus)


Background -Trans fatty acids are produced either by industrial hydrogenation or by biohydrogenation in the rumens of cows and sheep. Industrial trans fatty acids lower high-density lipoprotein (HDL) cholesterol, raise low-density lipoprotein (LDL) cholesterol, and increase the risk of coronary heart disease. The effects of trans fatty acids from ruminants are less clear. We investigated the effect on blood lipids of cis-9, trans-11 conjugated linoleic acid (CLA), a trans fatty acid largely restricted to ruminant fats. Methodology/Principal Findings - Sixty-one healthy women and men were sequentially fed each of three diets for three weeks, in random order, for a total of nine weeks. Diets were identical except for 7% of energy (approximately 20 g/day), which was provided either by oleic acid, by industrial trans fatty acids, or by a mixture of 80% cis-9, trans-11 and 20% trans-10, cis-12 CLA. After the oleic acid diet, mean (± SD) serum LDL cholesterol was 2.68±0.62 mmol/L compared to 3.00±0.66 mmol/L after industrial trans fatty acids (p
Original languageEnglish
Article numbere9000
Number of pages7
JournalPLoS ONE
Issue number2
Publication statusPublished - 2010


  • trans-fatty-acids
  • coronary heart-disease
  • middle-aged men
  • body-composition
  • cardiovascular-disease
  • lipid-metabolism
  • hdl cholesterol
  • blood-lipids
  • high-density
  • supplementation

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