Effect of 4-Week Consumption of Soy Kori-tofu on Cardiometabolic Health Markers: A Double-Blind Randomized Controlled Cross-Over Trial in Adults with Mildly Elevated Cholesterol Levels

M. van den Belt, Sandra van der Haar, Els Oosterink, Tom van Loenhout, Takahiro Ishiguro, Diederik Esser*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Kori-tofu is a frozen soy tofu, and soy consumption is associated with positive effects on cardiometabolic health markers. We aimed to assess the potential of Kori-tofu to improve cardiometabolic health outcomes in humans by repetitive daily consumption. In a double-blind randomized controlled cross-over trial, 45 subjects aged 40–70 years with (mildly) elevated cholesterol levels, received a four week Kori-tofu intervention or whey protein control intervention with a four week wash-out period in between. Cardiometabolic biomarkers were measured before and after both interventions. A significant decrease in total, low-density lipids (LDL), and high-density lipids (HDL) cholesterol, Hemoglobin A1c (HbA1c), fructosamine and systolic blood pressure was observed within the Kori-tofu intervention. However, many of these findings were also observed in the control intervention. Only adiponectin changes were different between treatments but did not change significantly within interventions. Improvements in cardiometabolic markers within the Kori-tofu intervention point toward potential beneficial health effects. Due to the lack of significant effects as compared to control, there is, however, currently no substantiating evidence to claim that Kori-tofu has beneficial effects on cardiometabolic health.
Original languageEnglish
Article number49
JournalNutrients
Volume15
Issue number1
Early online date22 Dec 2022
DOIs
Publication statusPublished - Jan 2023

Keywords

  • Kori-tofu
  • Cholesterol
  • soy protein
  • LDL
  • total cholesterol
  • cardiometabolic risk factors
  • glucose metabolism
  • blood pressure

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