Early-life gut microbiota under physiological and pathological conditions : the central role of combined meta-omics-based approaches

F. Del Chierico, P. Vernocchi, L. Bonizzi, W.M. de Vos

Research output: Contribution to journalArticleAcademicpeer-review

49 Citations (Scopus)

Abstract

The establishment of gut microbiota immediately after birth is modulated by different mechanisms that can be considered specific determinants of temporal and spatial variability. Over the last few years, molecular methods have been offering a complementary support to the classical microbiology, often underpowered by its inability to provide unbiased representation of gut microbiota. The advent of high-throughput-omics-based methods has opened new avenues in the knowledge of the gut ecosystem by shedding light on its shape and modulation. Such methods may unveil taxa distribution, role and density of microbial habitants, hence highlighting individual phenotyping (physiological traits) and their relationship with gut dysbiosis, inflammation processes, metabolic disorders (pathological conditions). Synergic meta-omics or "systems biology"-based approaches may concur in providing advanced information on microbiota establishment and pathogen control. During early-life stages this massive amount of data may provide gut microbiota descriptive and functional charts which can be exploited to perform a good practice in childcare and pediatrics, thus providing nutraceutical benefits and endorsing healthy development and aging. This article is part of a Special Issue entitled: Translational Proteomics
Original languageEnglish
Pages (from-to)4580-4587
JournalJournal of Proteomics
Volume75
Issue number15
DOIs
Publication statusPublished - 2012

Keywords

  • inflammatory-bowel-disease
  • intestinal microbiota
  • systems biology
  • fecal microbiota
  • metabonomics
  • newborns
  • host
  • identification
  • pathogenesis
  • communities

Fingerprint

Dive into the research topics of 'Early-life gut microbiota under physiological and pathological conditions : the central role of combined meta-omics-based approaches'. Together they form a unique fingerprint.

Cite this