Abstract: Unexpectedly, primary concern of bio-pharmaceutical industry is not optimisation of product yield or cost reduction, but consistency in production and product quality. This paper describes the methodology and experimental results of specific growth-rate control for vaccine production. The controller is based on four modules: specific growth rate observer, biomass observer, feed calculation, and feedback controller. Peculiarities are: the algorithm is based on oxygen uptake rate only, the organism is dual-substrate limited and requires multiple feed rates, the algorithm proved to work well in labscale experiments, consistency is improved, and production efficiency increased up to 4 times.
|Publication status||Published - 2004|