Dual substrate feedback control of specific growth-rate in vaccine production

R. Neeleman, E.C. Beuvery, D. Vries, G. van Straten, A.J.B. van Boxtel

Research output: Contribution to conferenceConference paperAcademicpeer-review

Abstract

Abstract: Unexpectedly, primary concern of bio-pharmaceutical industry is not optimisation of product yield or cost reduction, but consistency in production and product quality. This paper describes the methodology and experimental results of specific growth-rate control for vaccine production. The controller is based on four modules: specific growth rate observer, biomass observer, feed calculation, and feedback controller. Peculiarities are: the algorithm is based on oxygen uptake rate only, the organism is dual-substrate limited and requires multiple feed rates, the algorithm proved to work well in labscale experiments, consistency is improved, and production efficiency increased up to 4 times.
Original languageEnglish
Publication statusPublished - 2004

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    Neeleman, R., Beuvery, E. C., Vries, D., van Straten, G., & van Boxtel, A. J. B. (2004). Dual substrate feedback control of specific growth-rate in vaccine production.