Dual substrate feedback control of specific growth-rate in vaccine production

R. Neeleman; E.C. Beuvery; D. Vries; G. van Straten; A.J.B. van Boxtel

Dual substrate feedback control of specific growth-rate in vaccine production

R. Neeleman, E.C. Beuvery, D. Vries, G. van Straten, A.J.B. van Boxtel

VLAG

Research output: Contribution to conference › Conference paper › Academic › peer-review

Abstract

Abstract: Unexpectedly, primary concern of bio-pharmaceutical industry is not optimisation of product yield or cost reduction, but consistency in production and product quality. This paper describes the methodology and experimental results of specific growth-rate control for vaccine production. The controller is based on four modules: specific growth rate observer, biomass observer, feed calculation, and feedback controller. Peculiarities are: the algorithm is based on oxygen uptake rate only, the organism is dual-substrate limited and requires multiple feed rates, the algorithm proved to work well in labscale experiments, consistency is improved, and production efficiency increased up to 4 times.

Original language	English
Publication status	Published - 2004

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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@conference{64fd8c1da71a4f2eb158eee46baafabf,

title = "Dual substrate feedback control of specific growth-rate in vaccine production",

abstract = "Abstract: Unexpectedly, primary concern of bio-pharmaceutical industry is not optimisation of product yield or cost reduction, but consistency in production and product quality. This paper describes the methodology and experimental results of specific growth-rate control for vaccine production. The controller is based on four modules: specific growth rate observer, biomass observer, feed calculation, and feedback controller. Peculiarities are: the algorithm is based on oxygen uptake rate only, the organism is dual-substrate limited and requires multiple feed rates, the algorithm proved to work well in labscale experiments, consistency is improved, and production efficiency increased up to 4 times.",

author = "R. Neeleman and E.C. Beuvery and D. Vries and {van Straten}, G. and {van Boxtel}, A.J.B.",

year = "2004",

language = "English",

}

TY - CONF

T1 - Dual substrate feedback control of specific growth-rate in vaccine production

AU - Neeleman, R.

AU - Beuvery, E.C.

AU - Vries, D.

AU - van Straten, G.

AU - van Boxtel, A.J.B.

PY - 2004

Y1 - 2004

N2 - Abstract: Unexpectedly, primary concern of bio-pharmaceutical industry is not optimisation of product yield or cost reduction, but consistency in production and product quality. This paper describes the methodology and experimental results of specific growth-rate control for vaccine production. The controller is based on four modules: specific growth rate observer, biomass observer, feed calculation, and feedback controller. Peculiarities are: the algorithm is based on oxygen uptake rate only, the organism is dual-substrate limited and requires multiple feed rates, the algorithm proved to work well in labscale experiments, consistency is improved, and production efficiency increased up to 4 times.

AB - Abstract: Unexpectedly, primary concern of bio-pharmaceutical industry is not optimisation of product yield or cost reduction, but consistency in production and product quality. This paper describes the methodology and experimental results of specific growth-rate control for vaccine production. The controller is based on four modules: specific growth rate observer, biomass observer, feed calculation, and feedback controller. Peculiarities are: the algorithm is based on oxygen uptake rate only, the organism is dual-substrate limited and requires multiple feed rates, the algorithm proved to work well in labscale experiments, consistency is improved, and production efficiency increased up to 4 times.

M3 - Conference paper

ER -

Dual substrate feedback control of specific growth-rate in vaccine production

Abstract

UN SDGs

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