Domestication Shapes Recombination Patterns in Tomato

R.R. Fuentes, D. de Ridder, A.D.J. van Dijk*, S.A. Peters*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

Abstract

Meiotic recombination is a biological process of key importance in breeding, to generate genetic diversity and develop novel or agronomically relevant haplotypes. In crop tomato, recombination is curtailed as manifested by linkage disequilibrium decay over a longer distance and reduced diversity compared with wild relatives. Here, we compared domesticated and wild populations of tomato and found an overall conserved recombination landscape, with local changes in effective recombination rate in specific genomic regions. We also studied the dynamics of recombination hotspots resulting from domestication and found that loss of such hotspots is associated with selective sweeps, most notably in the pericentromeric heterochromatin. We detected footprints of genetic changes and structural variants, among them associated with transposable elements, linked with hotspot divergence during domestication, likely causing fine-scale alterations to recombination patterns and resulting in linkage drag.
Original languageEnglish
Article numbermsab287
JournalMolecular Biology and Evolution
Volume39
Issue number1
Early online date1 Oct 2021
DOIs
Publication statusPublished - 7 Jan 2022

Keywords

  • domestication
  • heterochromatin
  • recombination
  • selective sweeps
  • structural variants
  • transposable elements

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