DNA modification

M. Vlot (Inventor), S.J.J. Brouns (Inventor)

Research output: PatentOther research output

Abstract

The invention relates to the field of genetic engineering, and to the modification of nucleic acids and organismal genomes in particular. Specifically, the invention concerns the chemical modification of nucleic acids for the improved transformation of cells. Accordingly, the invention provides for modified nucleic acids, methods of modifying nucleic acids, methods of transforming cells and methods for the sequence-directed site-specific genetic modification of cells. The invention additionally encompasses cells transformed with modified nucleic acids and expression constructs for delivery and expression of modified nucleic acids. The nucleic acids, expression constructs, cells and methods of the invention find application in many areas of biotechnology, including, for example, genome editing.
Original languageEnglish
Patent numberWO2017055514
Priority date30/09/15
Publication statusPublished - 6 Apr 2017

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Nucleic Acids
Patents and inventions
DNA
Genes
Genetic engineering
Chemical modification
Biotechnology
Cells

Cite this

Vlot, M., & Brouns, S. J. J. (2017). DNA modification. (Patent No. WO2017055514).
Vlot, M. (Inventor) ; Brouns, S.J.J. (Inventor). / DNA modification. Patent No.: WO2017055514.
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Vlot, M & Brouns, SJJ 2017, DNA modification, Patent No. WO2017055514.

DNA modification. / Vlot, M. (Inventor); Brouns, S.J.J. (Inventor).

Patent No.: WO2017055514.

Research output: PatentOther research output

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AU - Brouns, S.J.J.

PY - 2017/4/6

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N2 - The invention relates to the field of genetic engineering, and to the modification of nucleic acids and organismal genomes in particular. Specifically, the invention concerns the chemical modification of nucleic acids for the improved transformation of cells. Accordingly, the invention provides for modified nucleic acids, methods of modifying nucleic acids, methods of transforming cells and methods for the sequence-directed site-specific genetic modification of cells. The invention additionally encompasses cells transformed with modified nucleic acids and expression constructs for delivery and expression of modified nucleic acids. The nucleic acids, expression constructs, cells and methods of the invention find application in many areas of biotechnology, including, for example, genome editing.

AB - The invention relates to the field of genetic engineering, and to the modification of nucleic acids and organismal genomes in particular. Specifically, the invention concerns the chemical modification of nucleic acids for the improved transformation of cells. Accordingly, the invention provides for modified nucleic acids, methods of modifying nucleic acids, methods of transforming cells and methods for the sequence-directed site-specific genetic modification of cells. The invention additionally encompasses cells transformed with modified nucleic acids and expression constructs for delivery and expression of modified nucleic acids. The nucleic acids, expression constructs, cells and methods of the invention find application in many areas of biotechnology, including, for example, genome editing.

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Vlot M, Brouns SJJ, inventors. DNA modification. WO2017055514. 2017 Apr 6.