Diversity of Bipolaris species in clinical samples in the United States and their antifungal susceptibility profiles

K.C. da Cunha, D.A. Sutton, A.W. Fothergill, J. Cano, J. Gené, H. Madrid, S. de Hoog, P.W. Crous, J. Guarro

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Abstract

A set of 104 isolates from human clinical samples from the United States, morphologically compatible with Bipolaris, were morphologically and molecularly identified through the sequence analysis of the internal transcribed space (ITS) region of the nuclear ribosomal DNA (rDNA). The predominant species was Bipolaris spicifera (67.3%), followed by B. hawaiiensis (18.2%), B. cynodontis (8.6%), B. micropus (2.9%), B. australiensis (2%), and B. setariae (1%). Bipolaris cynodontis, B. micropus, and B. setariae represent new records from clinical samples. The most common anatomical sites where isolates were recovered were the nasal region (30.7%), skin (19.2%), lungs (14.4%), and eyes (12.5%). The antifungal susceptibilities of 5 species of Bipolaris to 9 drugs are provided. With the exception of fluconazole and flucytosine, the antifungals tested showed good activity.
Original languageEnglish
Pages (from-to)4061-4066
JournalJournal of Clinical Microbiology
Volume50
DOIs
Publication statusPublished - 2012

Fingerprint

Flucytosine
Fluconazole
Ribosomal DNA
Nose
Sequence Analysis
Lung
Skin
Pharmaceutical Preparations

Keywords

  • allergic bronchopulmonary mycosis
  • fungal sinusitis
  • disseminated infection
  • amphotericin-b
  • spicifera
  • hawaiiensis
  • pheohyphomycosis
  • australiensis
  • itraconazole
  • voriconazole

Cite this

da Cunha, K. C., Sutton, D. A., Fothergill, A. W., Cano, J., Gené, J., Madrid, H., ... Guarro, J. (2012). Diversity of Bipolaris species in clinical samples in the United States and their antifungal susceptibility profiles. Journal of Clinical Microbiology, 50, 4061-4066. https://doi.org/10.1128/JCM.01965-12
da Cunha, K.C. ; Sutton, D.A. ; Fothergill, A.W. ; Cano, J. ; Gené, J. ; Madrid, H. ; de Hoog, S. ; Crous, P.W. ; Guarro, J. / Diversity of Bipolaris species in clinical samples in the United States and their antifungal susceptibility profiles. In: Journal of Clinical Microbiology. 2012 ; Vol. 50. pp. 4061-4066.
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title = "Diversity of Bipolaris species in clinical samples in the United States and their antifungal susceptibility profiles",
abstract = "A set of 104 isolates from human clinical samples from the United States, morphologically compatible with Bipolaris, were morphologically and molecularly identified through the sequence analysis of the internal transcribed space (ITS) region of the nuclear ribosomal DNA (rDNA). The predominant species was Bipolaris spicifera (67.3{\%}), followed by B. hawaiiensis (18.2{\%}), B. cynodontis (8.6{\%}), B. micropus (2.9{\%}), B. australiensis (2{\%}), and B. setariae (1{\%}). Bipolaris cynodontis, B. micropus, and B. setariae represent new records from clinical samples. The most common anatomical sites where isolates were recovered were the nasal region (30.7{\%}), skin (19.2{\%}), lungs (14.4{\%}), and eyes (12.5{\%}). The antifungal susceptibilities of 5 species of Bipolaris to 9 drugs are provided. With the exception of fluconazole and flucytosine, the antifungals tested showed good activity.",
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da Cunha, KC, Sutton, DA, Fothergill, AW, Cano, J, Gené, J, Madrid, H, de Hoog, S, Crous, PW & Guarro, J 2012, 'Diversity of Bipolaris species in clinical samples in the United States and their antifungal susceptibility profiles' Journal of Clinical Microbiology, vol. 50, pp. 4061-4066. https://doi.org/10.1128/JCM.01965-12

Diversity of Bipolaris species in clinical samples in the United States and their antifungal susceptibility profiles. / da Cunha, K.C.; Sutton, D.A.; Fothergill, A.W.; Cano, J.; Gené, J.; Madrid, H.; de Hoog, S.; Crous, P.W.; Guarro, J.

In: Journal of Clinical Microbiology, Vol. 50, 2012, p. 4061-4066.

Research output: Contribution to journalArticleAcademicpeer-review

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T1 - Diversity of Bipolaris species in clinical samples in the United States and their antifungal susceptibility profiles

AU - da Cunha, K.C.

AU - Sutton, D.A.

AU - Fothergill, A.W.

AU - Cano, J.

AU - Gené, J.

AU - Madrid, H.

AU - de Hoog, S.

AU - Crous, P.W.

AU - Guarro, J.

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N2 - A set of 104 isolates from human clinical samples from the United States, morphologically compatible with Bipolaris, were morphologically and molecularly identified through the sequence analysis of the internal transcribed space (ITS) region of the nuclear ribosomal DNA (rDNA). The predominant species was Bipolaris spicifera (67.3%), followed by B. hawaiiensis (18.2%), B. cynodontis (8.6%), B. micropus (2.9%), B. australiensis (2%), and B. setariae (1%). Bipolaris cynodontis, B. micropus, and B. setariae represent new records from clinical samples. The most common anatomical sites where isolates were recovered were the nasal region (30.7%), skin (19.2%), lungs (14.4%), and eyes (12.5%). The antifungal susceptibilities of 5 species of Bipolaris to 9 drugs are provided. With the exception of fluconazole and flucytosine, the antifungals tested showed good activity.

AB - A set of 104 isolates from human clinical samples from the United States, morphologically compatible with Bipolaris, were morphologically and molecularly identified through the sequence analysis of the internal transcribed space (ITS) region of the nuclear ribosomal DNA (rDNA). The predominant species was Bipolaris spicifera (67.3%), followed by B. hawaiiensis (18.2%), B. cynodontis (8.6%), B. micropus (2.9%), B. australiensis (2%), and B. setariae (1%). Bipolaris cynodontis, B. micropus, and B. setariae represent new records from clinical samples. The most common anatomical sites where isolates were recovered were the nasal region (30.7%), skin (19.2%), lungs (14.4%), and eyes (12.5%). The antifungal susceptibilities of 5 species of Bipolaris to 9 drugs are provided. With the exception of fluconazole and flucytosine, the antifungals tested showed good activity.

KW - allergic bronchopulmonary mycosis

KW - fungal sinusitis

KW - disseminated infection

KW - amphotericin-b

KW - spicifera

KW - hawaiiensis

KW - pheohyphomycosis

KW - australiensis

KW - itraconazole

KW - voriconazole

U2 - 10.1128/JCM.01965-12

DO - 10.1128/JCM.01965-12

M3 - Article

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SP - 4061

EP - 4066

JO - Journal of Clinical Microbiology

JF - Journal of Clinical Microbiology

SN - 0095-1137

ER -