Distribution of month of birth of individuals with autism spectrum disorder differs from the general population in the Netherlands

Anna Ciéslińska, Jannicke Simmelink, M. Teodorowicz, J.C.M. Verhoef, H. Tobi, H.F.J. Savelkoul

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

Abstract

The prevalence of autism spectrum disorders (ASDs) is causally dependent on genetic and environmental influences. We investigated whether autism spectrum disorders are associated with month of birth compared to the general population using a retrospective study, comparing ASD cases (n = 3478) with the general population (n = 2,716,876) born between 1995 and 2008. Associations were examined using χ2 tests and Walter and Elwood’s seasonality χ2 tests for the total ASD group, and separately for autistic disorder and Asperger syndrome. For the total ASD group, the distribution of month of birth was different compared to the general population (p < 0.0001), with July as the highest contributor, and a season-of-birth effect was found for this group (p = 0.02). For the autistic disorder group, the months of birth distribution were different (p = 0.01), with July as the highest contributor. No season-of-birth effect over the year was found (p = 0.09). No association was found for the months of birth of individuals with Asperger syndrome (p = 0.06), with no seasonal trend over the year (p = 0.60). In conclusion, a drop in sun exposure during the first trimester of pregnancy might explain the peak in July births and the associated risk for ASD development.
Original languageEnglish
Title of host publicationAutism - Paradigms, Recent Research and Clinical Applications
EditorsM. Fitzgerald, J. Yip
PublisherInTech
Number of pages43
ISBN (Print)9789535130796
Publication statusPublished - 12 Apr 2017

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Netherlands
Parturition
Population
Asperger Syndrome
Autistic Disorder
Solar System
First Pregnancy Trimester
Autism Spectrum Disorder
Retrospective Studies

Cite this

Ciéslińska, A., Simmelink, J., Teodorowicz, M., Verhoef, J. C. M., Tobi, H., & Savelkoul, H. F. J. (2017). Distribution of month of birth of individuals with autism spectrum disorder differs from the general population in the Netherlands. In M. Fitzgerald, & J. Yip (Eds.), Autism - Paradigms, Recent Research and Clinical Applications InTech.
Ciéslińska, Anna ; Simmelink, Jannicke ; Teodorowicz, M. ; Verhoef, J.C.M. ; Tobi, H. ; Savelkoul, H.F.J. / Distribution of month of birth of individuals with autism spectrum disorder differs from the general population in the Netherlands. Autism - Paradigms, Recent Research and Clinical Applications. editor / M. Fitzgerald ; J. Yip. InTech, 2017.
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Ciéslińska, A, Simmelink, J, Teodorowicz, M, Verhoef, JCM, Tobi, H & Savelkoul, HFJ 2017, Distribution of month of birth of individuals with autism spectrum disorder differs from the general population in the Netherlands. in M Fitzgerald & J Yip (eds), Autism - Paradigms, Recent Research and Clinical Applications. InTech.

Distribution of month of birth of individuals with autism spectrum disorder differs from the general population in the Netherlands. / Ciéslińska, Anna; Simmelink, Jannicke; Teodorowicz, M.; Verhoef, J.C.M.; Tobi, H.; Savelkoul, H.F.J.

Autism - Paradigms, Recent Research and Clinical Applications. ed. / M. Fitzgerald; J. Yip. InTech, 2017.

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

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AB - The prevalence of autism spectrum disorders (ASDs) is causally dependent on genetic and environmental influences. We investigated whether autism spectrum disorders are associated with month of birth compared to the general population using a retrospective study, comparing ASD cases (n = 3478) with the general population (n = 2,716,876) born between 1995 and 2008. Associations were examined using χ2 tests and Walter and Elwood’s seasonality χ2 tests for the total ASD group, and separately for autistic disorder and Asperger syndrome. For the total ASD group, the distribution of month of birth was different compared to the general population (p < 0.0001), with July as the highest contributor, and a season-of-birth effect was found for this group (p = 0.02). For the autistic disorder group, the months of birth distribution were different (p = 0.01), with July as the highest contributor. No season-of-birth effect over the year was found (p = 0.09). No association was found for the months of birth of individuals with Asperger syndrome (p = 0.06), with no seasonal trend over the year (p = 0.60). In conclusion, a drop in sun exposure during the first trimester of pregnancy might explain the peak in July births and the associated risk for ASD development.

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Ciéslińska A, Simmelink J, Teodorowicz M, Verhoef JCM, Tobi H, Savelkoul HFJ. Distribution of month of birth of individuals with autism spectrum disorder differs from the general population in the Netherlands. In Fitzgerald M, Yip J, editors, Autism - Paradigms, Recent Research and Clinical Applications. InTech. 2017