Distinct physiological, plasma amino acid, and liver transcriptome responses to purified dietary beef, chicken, fish, and pork proteins in young rats

Shangxin Song, G.J.E.J. Hooiveld, Mengjie Li, Fan Zhao, Wei Zhang, Xinglian Xu, M.R. Müller, Chunbao Li, Guanghong Zhou

Research output: Contribution to journalArticleAcademicpeer-review

7 Citations (Scopus)

Abstract

Young rats received semi-synthetic diets for 1 wk that differed only
regarding protein source; casein (reference) was replaced by beef, chicken, fish, or pork proteins.
Compared to casein, all proteins, except pork, increased total plasma AA concentrations.
Pork protein reduced adipose tissue mass and liver triacylglycerol, which was accompanied
by increased plasma triacylglycerol concentrations. Plasma cholesterol was reduced by fish
protein. The number of differentially expressed genes ranged between 609 (pork) and 1258
(chicken); on average one-third of the changes were specific for each meat protein. Pathway
responses were most similar for beef and chicken, followed by pork and fish. Although the
extent varied, allmeat proteins inducedmRNAtranslation, antigen processing/presentation, intracellular
vesicular trafficking, and oxidoreductive-transformation pathways, and suppressed
signal-transduction (Notch, TGFB/SMAD, insulin) and mitochondrial biogenesis pathways.
Lipid- and AA-metabolic pathways were repressed, except by pork. AA-transport pathways were
induced by beef and fish only, and complement/coagulation-pathways were suppressed by
chicken and beef. Fish suppressed nuclear-transport and cofactor metabolism.
Conclusion: To conclude, short-term feeding of different meat proteins resulted in distinct
Original languageEnglish
Pages (from-to)1199-1205
JournalMolecular Nutrition & Food Research
Volume60
Issue number5
DOIs
Publication statusPublished - 2016

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