Distinct Longitudinal Associations of MBL, MASP-1, MASP-2, MASP-3, and MAp44 With Endothelial Dysfunction and Intima-Media Thickness: The CODAM Study

E. Hertle, I.C.W. Arts, C.J.H. van der Kallen, E.J.M. Feskens, C.G. Schalkwijk, I. Hoffmann-Petersen, S. Thiel, C.D. Stehouwer, M.M. Greevenbroek

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7 Citations (Scopus)

Abstract

Previous studies suggested that the lectin-complement pathway plays a complex role in cardiovascular disease (CVD). To date, no prospective human studies have investigated the relationship between the initiating factor of the lectin pathway, that is, mannose-binding lectin (MBL), and low-grade inflammation, endothelial dysfunction, or carotid intima–media thickness (cIMT). Moreover, MBL-associated proteases (MASPs) and MBL-associated proteins (MAps), which mediate downstream complement activation, have not been studied in the development of CVD.
Original languageEnglish
Pages (from-to)1278-1285
JournalArteriosclerosis Thrombosis and Vascular Biology
Volume36
Issue number6
DOIs
Publication statusPublished - 2016

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