Discovery of inhibitors of bacterial histidine kinases

N.R. Velikova

Research output: Thesisinternal PhD, WU

Abstract

Discovery of Inhibitors of Bacterial Histidine Kinases Summary

The thesis is on novel antibacterial drug discovery (http://youtu.be/NRMWOGgeysM). Using structure-based and fragment-based drug discovery approach, we have identified small-molecule histidine-kinase inhibitors with antibacterial effect against multi-drug resistant strains, including clinical isolates of multi-drug resistant bacteria such as MRSA. Furthermore, we have shown broadening of the antibacterial spectrum and lowering the toxicity of the histidine-kinase inhibitors using nanoparticles. The results open up exciting possibilities for development of novel antibacterial(nano)medicines.

 

Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • Wageningen University
Supervisors/Advisors
  • Wells, Jerry, Promotor
  • Marina, A., Co-promotor, External person
Award date7 Nov 2014
Place of PublicationWageningen
Publisher
Print ISBNs9789462571112
Publication statusPublished - 2014

Keywords

  • host pathogen interactions
  • bacteria
  • kinases
  • histidine
  • drug resistance
  • antibiotics
  • microbiology

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