Direct and quantitative in-situ analysis of third-hand smoke in and on various matrices by ambient desorption corona beam ionization mass spectrometry

Ke Min, Ping Guo, Dongying Chen, Si Huang, Wei Luo, Ming Ma, Bo Chen*, Shouzhou Yao*, H. Zuilhof*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)

Abstract

Third-hand smoke (THS) is composed of surface-deposited remnants resulting from tabacco-smoking. Because THS components have properties of remaining on, re-emitting from and reacting on and with surfaces, in-situ analysis of the components on different surfaces is both in high demand and challenging. The aim of this study is to establish desorption corona beam ionization (DCBI)-MS/MS as an analytical tool for THS research. To this end, an in-situ DCBI-MS/MS approach was developed for the quantitative analysis of typical THS environmental markers, i.e. nicotine and cotinine on different surfaces such as fruits, cotton clothing, glass, and toys etc. The limits of detection of nicotine and cotinine were both 1.4 μg m-2. Low-temperature DCBI-MS/MS was applied to the direct detection of THS on fingers without any skin damage. Smoking-related biomarkers analyses in urine were accomplished, with a 10 s DCBI analysis time. The on-surface tobacco-specific nitrosamines (TSNAs), such as 1-(N-methyl-N-nitrosamino)-1-(3-pyridinyl)-4-butanal) (NNA), 4-(methylnitrosamino)-1-(3-pyridinyl)-1-butanone (NNK), and N-nitroso nornicotine (NNN) were in-situ successfully detected in dust samples.
Original languageEnglish
Article number121330
JournalTalanta
Volume219
DOIs
Publication statusPublished - 1 Nov 2020

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