@article{6bc64ee1f20d41369089e35d3172576c,
title = "Diffusible repression of cytokinin signalling produces endodermal symmetry and passage cells",
abstract = "In vascular plants, the root endodermis surrounds the central vasculature as a protective sheath that is analogous to the polarized epithelium in animals, and contains ring-shaped Casparian strips that restrict diffusion. After an initial lag phase, individual endodermal cells suberize in an apparently random fashion to produce 'patchy' suberization that eventually generates a zone of continuous suberin deposition. Casparian strips and suberin lamellae affect paracellular and transcellular transport, respectively. Most angiosperms maintain some isolated cells in an unsuberized state as so-called 'passage cells', which have previously been suggested to enable uptake across an otherwise-impermeable endodermal barrier. Here we demonstrate that these passage cells are late emanations of a meristematic patterning process that reads out the underlying non-radial symmetry of the vasculature. This process is mediated by the non-cell-autonomous repression of cytokinin signalling in the root meristem, and leads to distinct phloem- and xylem-pole-associated endodermal cells. The latter cells can resist abscisic acid-dependent suberization to produce passage cells. Our data further demonstrate that, during meristematic patterning, xylem-pole-associated endodermal cells can dynamically alter passage-cell numbers in response to nutrient status, and that passage cells express transporters and locally affect the expression of transporters in adjacent cortical cells.",
author = "Andersen, {Tonni Grube} and Sadaf Naseer and Robertas Ursache and Brecht Wybouw and Wouter Smet and {De Rybel}, Bert and Vermeer, {Joop E.M.} and Niko Geldner",
year = "2018",
month = mar,
day = "22",
doi = "10.1038/nature25976",
language = "English",
volume = "555",
pages = "529--533",
journal = "Nature",
issn = "0028-0836",
publisher = "Nature Publishing Group",
number = "7697",
}