Different transcriptional response between susceptible and resistant common carp (Cyprinus carpio) fish hints on the mechanism of CyHV-3 disease resistance

Roni Tadmor-Levi; Adi Doron-Faigenboim; Evgeniya Marcos-Hadad; Jules Petit; Gideon Hulata; Maria Forlenza; Geert F. Wiegertjes; Lior David

doi:10.1186/s12864-019-6391-9

Different transcriptional response between susceptible and resistant common carp (Cyprinus carpio) fish hints on the mechanism of CyHV-3 disease resistance

Roni Tadmor-Levi, Adi Doron-Faigenboim, Evgeniya Marcos-Hadad, Jules Petit, Gideon Hulata, Maria Forlenza, Geert F. Wiegertjes, Lior David^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

25 Citations (Scopus)

Abstract

Infectious disease outbreaks form major setbacks to aquaculture production and to further development of this important sector. Cyprinid herpes virus-3 (CyHV-3) is a dsDNA virus widely hampering production of common carp (Cyprinus carpio), one of the most farmed fish species worldwide. Genetically disease resistant strains are highly sought after as a sustainable solution to this problem. To study the genetic basis and cellular pathways underlying disease resistance, RNA-Seq was used to characterize transcriptional responses of susceptible and resistant fish at day 4 after CyHV-3 infection.

Original language	English
Article number	1019
Journal	BMC Genomics
Volume	20
Issue number	1
DOIs	https://doi.org/10.1186/s12864-019-6391-9
Publication status	Published - 26 Dec 2019

Keywords

Aquaculture
Chemokines
Disease resistance
Fish disease
Immuno-genetics
Koi herpes virus (KHV)
Neutrophils
RNA sequencing
Wild-type strain

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1186/s12864-019-6391-9Licence: CC BY

RNA sequencing of susceptible and resistant common carp before and after infection with CyHV-3
Tadmor-Levi, R. (Creator), Doron-Faigenboim, A. (Creator), Marcos-Hadad, E. (Creator), Petit, J. (Creator), Hulata, G. (Creator), Forlenza, M. (Creator), Wiegertjes, G. (Creator) & David, L. (Creator), Hebrew University of Jerusalem, 15 Sept 2019
https://www.ncbi.nlm.nih.gov/bioproject/PRJNA565549
Dataset
Different transcriptional response between susceptible and resistant common carp (Cyprinus carpio) fish hints on the mechanism of CyHV-3 disease resistance
Tadmor-Levi, R. (Creator), Doron-Faigenboim, A. (Creator), Marcos-Hadad, E. (Creator), Petit, J. (Creator), Hulata, G. (Creator), Forlenza, M. (Creator), Wiegertjes, G. F. (Creator) & David, L. (Creator), Hebrew University of Jerusalem, 27 Dec 2019
DOI: 10.6084/m9.figshare.c.4798188
Dataset

TARGETFISH: Targeted disease prophylaxis in European fish farming
1/10/12 → 30/09/17
Project: EU research project

Cite this

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title = "Different transcriptional response between susceptible and resistant common carp (Cyprinus carpio) fish hints on the mechanism of CyHV-3 disease resistance",

abstract = "Infectious disease outbreaks form major setbacks to aquaculture production and to further development of this important sector. Cyprinid herpes virus-3 (CyHV-3) is a dsDNA virus widely hampering production of common carp (Cyprinus carpio), one of the most farmed fish species worldwide. Genetically disease resistant strains are highly sought after as a sustainable solution to this problem. To study the genetic basis and cellular pathways underlying disease resistance, RNA-Seq was used to characterize transcriptional responses of susceptible and resistant fish at day 4 after CyHV-3 infection.",

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doi = "10.1186/s12864-019-6391-9",

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AU - Tadmor-Levi, Roni

AU - Doron-Faigenboim, Adi

AU - Marcos-Hadad, Evgeniya

AU - Petit, Jules

AU - Hulata, Gideon

AU - Forlenza, Maria

AU - Wiegertjes, Geert F.

AU - David, Lior

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Y1 - 2019/12/26

N2 - Infectious disease outbreaks form major setbacks to aquaculture production and to further development of this important sector. Cyprinid herpes virus-3 (CyHV-3) is a dsDNA virus widely hampering production of common carp (Cyprinus carpio), one of the most farmed fish species worldwide. Genetically disease resistant strains are highly sought after as a sustainable solution to this problem. To study the genetic basis and cellular pathways underlying disease resistance, RNA-Seq was used to characterize transcriptional responses of susceptible and resistant fish at day 4 after CyHV-3 infection.

AB - Infectious disease outbreaks form major setbacks to aquaculture production and to further development of this important sector. Cyprinid herpes virus-3 (CyHV-3) is a dsDNA virus widely hampering production of common carp (Cyprinus carpio), one of the most farmed fish species worldwide. Genetically disease resistant strains are highly sought after as a sustainable solution to this problem. To study the genetic basis and cellular pathways underlying disease resistance, RNA-Seq was used to characterize transcriptional responses of susceptible and resistant fish at day 4 after CyHV-3 infection.

KW - Aquaculture

KW - Chemokines

KW - Disease resistance

KW - Fish disease

KW - Immuno-genetics

KW - Koi herpes virus (KHV)

KW - Neutrophils

KW - RNA sequencing

KW - Wild-type strain

U2 - 10.1186/s12864-019-6391-9

DO - 10.1186/s12864-019-6391-9

M3 - Article

SN - 1471-2164

VL - 20

JO - BMC Genomics

JF - BMC Genomics

IS - 1

M1 - 1019

ER -

Different transcriptional response between susceptible and resistant common carp (Cyprinus carpio) fish hints on the mechanism of CyHV-3 disease resistance

Abstract

Keywords

UN SDGs

Access to Document

Fingerprint

Datasets

RNA sequencing of susceptible and resistant common carp before and after infection with CyHV-3

Different transcriptional response between susceptible and resistant common carp (Cyprinus carpio) fish hints on the mechanism of CyHV-3 disease resistance

Projects

TARGETFISH: Targeted disease prophylaxis in European fish farming

Cite this