Diets poor in fibre, vegetable protein and polyunsaturated fat are associated with inflammation and endothelial dysfunction in type 1 diabetes mellitus: the EURODIAB study

B.C.T. van Bussel, S.S. Soedamah-Muthu, R.M.A. Henry, C.G. Schalkwijk, I. Ferreira, N. Chaturvedi, M. Toeller, J.H. Fuller, C.D.A. Stehouwer

Research output: Chapter in Book/Report/Conference proceedingAbstract

Abstract

Background and aims: To investigate the association between nutrient consumption and biomarkers of endothelial dysfunction (ED) and low-grade inflammation (LGI) in type 1 diabetes mellitus. Materials and methods: We investigated 491 individuals. Nutrient consumption and lifestyle risk factors were measured in 1989 and 1997. Biomarkers of ED (von Willebrand factor, soluble vascular cell adhesion molecule-1 and soluble endothelial selectin) and LGI (C-reactive protein, interleukin-6 and tumour necrosis factor-a) were measured in 1997 and averaged into z scores. Nutrients were adjusted for total energy intake by the nutrient residual method. Data were analysed with generalised estimating equations. We report average 8-year differences in nutrient consumption per +1 standard deviation (SD) of 1997 ED or LGI z scores. Results are adjusted for sex, age, duration of diabetes, investigation centre, body mass index, energy intake, smoking behaviour and alcohol consumption, and other nutrients. Results: A one SD elevation in endothelial dysfunction z score was associated with a diet over an 8-year period that was lower in fibre [ß(95%CI); -0.09(-0.18;-0.004)], polyunsaturated fat [-0.18(-0.32;-0.05)] and vegetable protein [-0.10(-0.20;-0.001)]. For the low-grade inflammation z score the results showed a diet lower in fibre [-0.09(-0.17;-0.01)] and polyunsaturated fat [-0.14(-0.24;-0.03)], and higher in cholesterol [0.10(0.01;0.18)]. Conclusion: In type 1 diabetes mellitus, consumption of less fibre, polyunsaturated fat and vegetable protein and more cholesterol over an 8-year study period was associated with more ED and LGI. This supports the hypothesis that following the current dietary guidelines in type 1 diabetes mellitus may reduce cardiovascular disease risk by affecting ED and LGI favourably
Original languageEnglish
Title of host publicationAbstracts of the 47th EASD Annual Meeting, Lisbon, Portugal, 12-16 September 2011
PagesS12-S13
Volume54
Publication statusPublished - 2011
Event47th EASD Annual Meeting, Lisbon, Portugal -
Duration: 12 Sep 201116 Sep 2011

Conference

Conference47th EASD Annual Meeting, Lisbon, Portugal
Period12/09/1116/09/11

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van Bussel, B. C. T., Soedamah-Muthu, S. S., Henry, R. M. A., Schalkwijk, C. G., Ferreira, I., Chaturvedi, N., ... Stehouwer, C. D. A. (2011). Diets poor in fibre, vegetable protein and polyunsaturated fat are associated with inflammation and endothelial dysfunction in type 1 diabetes mellitus: the EURODIAB study. In Abstracts of the 47th EASD Annual Meeting, Lisbon, Portugal, 12-16 September 2011 (Vol. 54, pp. S12-S13)