Abstract
Background and aims: To investigate the association between nutrient consumption
and biomarkers of endothelial dysfunction (ED) and low-grade
inflammation (LGI) in type 1 diabetes mellitus.
Materials and methods: We investigated 491 individuals. Nutrient consumption
and lifestyle risk factors were measured in 1989 and 1997. Biomarkers
of ED (von Willebrand factor, soluble vascular cell adhesion molecule-1
and soluble endothelial selectin) and LGI (C-reactive protein, interleukin-6
and tumour necrosis factor-a) were measured in 1997 and averaged into z
scores. Nutrients were adjusted for total energy intake by the nutrient residual
method. Data were analysed with generalised estimating equations. We report
average 8-year differences in nutrient consumption per +1 standard deviation
(SD) of 1997 ED or LGI z scores. Results are adjusted for sex, age, duration
of diabetes, investigation centre, body mass index, energy intake, smoking
behaviour and alcohol consumption, and other nutrients.
Results: A one SD elevation in endothelial dysfunction z score was associated
with a diet over an 8-year period that was lower in fibre [ß(95%CI);
-0.09(-0.18;-0.004)], polyunsaturated fat [-0.18(-0.32;-0.05)] and vegetable
protein [-0.10(-0.20;-0.001)]. For the low-grade inflammation z score the
results showed a diet lower in fibre [-0.09(-0.17;-0.01)] and polyunsaturated
fat [-0.14(-0.24;-0.03)], and higher in cholesterol [0.10(0.01;0.18)].
Conclusion: In type 1 diabetes mellitus, consumption of less fibre, polyunsaturated
fat and vegetable protein and more cholesterol over an 8-year study
period was associated with more ED and LGI. This supports the hypothesis
that following the current dietary guidelines in type 1 diabetes mellitus may
reduce cardiovascular disease risk by affecting ED and LGI favourably
Original language | English |
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Title of host publication | Abstracts of the 47th EASD Annual Meeting, Lisbon, Portugal, 12-16 September 2011 |
Pages | S12-S13 |
Volume | 54 |
Publication status | Published - 2011 |
Event | 47th EASD Annual Meeting, Lisbon, Portugal - Duration: 12 Sept 2011 → 16 Sept 2011 |
Conference/symposium
Conference/symposium | 47th EASD Annual Meeting, Lisbon, Portugal |
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Period | 12/09/11 → 16/09/11 |