Dietary vitamin A intake below the recommended daily intake during pregnancy and the risk of congenital diaphragmatic hernia in the offspring

L.W.J.E. Beurskens, L.H. Schrijver, D. Tibboel, M.F. Wildhagen, M.F.C.M. Knapen, J. Lindemans, J.H.M. de Vries, R.P.M. Steegers-Theunissen

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19 Citations (Scopus)

Abstract

BACKGROUND Vitamin A has been related to the etiology of congenital diaphragmatic hernia (CDH). We performed a case-control study to investigate whether maternal dietary vitamin A intake is related to CDH in the offspring. METHODS Thirty-one pregnancies diagnosed with CDH and 46 control pregnancies were included during the study. After CDH diagnosis and inclusion of controls by risk set sampling, maternal vitamin A intake was investigated with a food frequency questionnaire. Serum retinol and retinol-binding protein were determined. Univariable and multivariable logistic regression models were used to calculate risk estimates with adjustment for potential confounders. RESULTS We found no significant differences in the overall nutrient and vitamin A intake between case and control mothers. After stratification in body mass index (BMI) categories, case mothers with normal weight showed a lower energy adjusted vitamin A intake (685 vs. 843 mu g retinol activity equivalents [RAEs] / day; p = 0.04) and a slightly lower serum retinol (1.58 vs. 1.67 mu mol/L; p = 0.08) than control mothers. Vitamin A intake
Original languageEnglish
Pages (from-to)60-66
JournalBirth Defects Res. Part A-Clin. Mol. Teratol.
Volume97
Issue number1
DOIs
Publication statusPublished - 2013

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