Dietary intake of vitamin d and calcium and breast cancer risk in the European prospective investigation into cancer and nutrition

S. Abbas, J. Linseisen, S. Rohrmann, J. Chang-Claude, P.H. Peeters, P. Engel, M. Brustad, E. Lund, G. Skeie, F.J.B. van Duijnhoven

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24 Citations (Scopus)

Abstract

Studies assessing the effects of vitamin D or calcium intake on breast cancer risk have been inconclusive. Furthermore, few studies have evaluated them jointly. This study is the largest so far examining the association of dietary vitamin D and calcium intake with breast cancer risk in the European Prospective Investigation into Cancer and Nutrition. During a mean follow-up of 8.8 yr, 7760 incident invasive breast cancer cases were identified among 319,985 women. Multivariable Cox proportional hazards regression was used to estimate hazard ratios (HR) and 95% confidence intervals (CI) for pre- and postmenopausal breast cancer risk. Comparing the highest with the lowest quintile of vitamin D intake, HR and 95% CI were 1.07 (0.87–1.32) and 1.02 (0.90–1.16) for pre- and postmenopausal women, respectively. The corresponding HR and 95% CIs for calcium intake were 0.98 (0.80–1.19) and 0.90 (0.79–1.02), respectively. For calcium intake in postmenopausal women, the test for trend was borderline statistically significant (Ptrend = 0.05). There was no significant interaction between vitamin D and calcium intake and cancer risk (Pinteraction = 0.57 and 0.22 in pre- and postmenopausal women, respectively). In this large prospective cohort, we found no evidence for an association between dietary vitamin D or calcium intake and breast cancer risk.
Original languageEnglish
Pages (from-to)178-187
JournalNutrition and Cancer
Volume65
Issue number2
DOIs
Publication statusPublished - 2013

Keywords

  • french e3n cohort
  • dairy-products
  • sunlight exposure
  • adolescent diet
  • women
  • micronutrients
  • calibration
  • metaanalysis
  • prevention

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