Dietary intake of B-vitamins, polymorphisms in thymidylate synthase and serine hydroxymethyltransferase1, and colorectal adenoma risk: A Dutch case-control study

M. van den Donk, M.H.P.W. Visker, J.L. Harryvan, F.J. Kok, E. Kampman

Research output: Contribution to journalArticleAcademicpeer-review

15 Citations (Scopus)

Abstract

Thymidylate synthase and serine hydroxymethyltransferase are involved in folate metabolism. In a case-control study, including 768 cases and 709 controls, we investigated the associations between colorectal adenomas and TS tandem repeat and SHMT1 C1420T polymorphisms, and the interplay with B-vitamins. The polymorphisms were not associated with adenomas, but there was a borderline significant interaction between TS genotype and vitamin B6: the association between vitamin B6 and adenomas seemed positive in TS 3R/3R individuals, but inverse in TS 2R/2R individuals. This study does not provide evidence for a role of SHMT1 genotype in adenoma occurrence. Future research has to indicate whether the TS-B6 interplay is a real effect or a chance finding.
Original languageEnglish
Pages (from-to)146-153
JournalCancer Letters
Volume250
Issue number1
DOIs
Publication statusPublished - 2007

Keywords

  • promoter enhancer region
  • plasma folate
  • cancer
  • gene
  • metabolism
  • methionine
  • genotype

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