Dietary intake of B-vitamins, polymorphisms in thymidylate synthase and serine hydroxymethyltransferase1, and colorectal adenoma risk: A Dutch case-control study

M. van den Donk; M.H.P.W. Visker; J.L. Harryvan; F.J. Kok; E. Kampman

doi:10.1016/j.canlet.2006.10.002

Dietary intake of B-vitamins, polymorphisms in thymidylate synthase and serine hydroxymethyltransferase1, and colorectal adenoma risk: A Dutch case-control study

M. van den Donk, M.H.P.W. Visker, J.L. Harryvan, F.J. Kok, E. Kampman

Research output: Contribution to journal › Article › Academic › peer-review

15 Citations (Scopus)

Abstract

Thymidylate synthase and serine hydroxymethyltransferase are involved in folate metabolism. In a case-control study, including 768 cases and 709 controls, we investigated the associations between colorectal adenomas and TS tandem repeat and SHMT1 C1420T polymorphisms, and the interplay with B-vitamins. The polymorphisms were not associated with adenomas, but there was a borderline significant interaction between TS genotype and vitamin B6: the association between vitamin B6 and adenomas seemed positive in TS 3R/3R individuals, but inverse in TS 2R/2R individuals. This study does not provide evidence for a role of SHMT1 genotype in adenoma occurrence. Future research has to indicate whether the TS-B6 interplay is a real effect or a chance finding.

Original language	English
Pages (from-to)	146-153
Journal	Cancer Letters
Volume	250
Issue number	1
DOIs	https://doi.org/10.1016/j.canlet.2006.10.002
Publication status	Published - 2007

Keywords

promoter enhancer region
plasma folate
cancer
gene
metabolism
methionine
genotype

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@article{3bb37ec3b9ad4333aa1cd4843d3f9b27,

title = "Dietary intake of B-vitamins, polymorphisms in thymidylate synthase and serine hydroxymethyltransferase1, and colorectal adenoma risk: A Dutch case-control study",

abstract = "Thymidylate synthase and serine hydroxymethyltransferase are involved in folate metabolism. In a case-control study, including 768 cases and 709 controls, we investigated the associations between colorectal adenomas and TS tandem repeat and SHMT1 C1420T polymorphisms, and the interplay with B-vitamins. The polymorphisms were not associated with adenomas, but there was a borderline significant interaction between TS genotype and vitamin B6: the association between vitamin B6 and adenomas seemed positive in TS 3R/3R individuals, but inverse in TS 2R/2R individuals. This study does not provide evidence for a role of SHMT1 genotype in adenoma occurrence. Future research has to indicate whether the TS-B6 interplay is a real effect or a chance finding.",

keywords = "promoter enhancer region, plasma folate, cancer, gene, metabolism, methionine, genotype",

author = "{van den Donk}, M. and M.H.P.W. Visker and J.L. Harryvan and F.J. Kok and E. Kampman",

year = "2007",

doi = "10.1016/j.canlet.2006.10.002",

language = "English",

volume = "250",

pages = "146--153",

journal = "Cancer Letters",

issn = "0304-3835",

publisher = "Elsevier",

number = "1",

}

Dietary intake of B-vitamins, polymorphisms in thymidylate synthase and serine hydroxymethyltransferase1, and colorectal adenoma risk: A Dutch case-control study. / van den Donk, M.; Visker, M.H.P.W.; Harryvan, J.L.; Kok, F.J.; Kampman, E.

In: Cancer Letters, Vol. 250, No. 1, 2007, p. 146-153.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Dietary intake of B-vitamins, polymorphisms in thymidylate synthase and serine hydroxymethyltransferase1, and colorectal adenoma risk: A Dutch case-control study

AU - van den Donk, M.

AU - Visker, M.H.P.W.

AU - Harryvan, J.L.

AU - Kok, F.J.

AU - Kampman, E.

PY - 2007

Y1 - 2007

N2 - Thymidylate synthase and serine hydroxymethyltransferase are involved in folate metabolism. In a case-control study, including 768 cases and 709 controls, we investigated the associations between colorectal adenomas and TS tandem repeat and SHMT1 C1420T polymorphisms, and the interplay with B-vitamins. The polymorphisms were not associated with adenomas, but there was a borderline significant interaction between TS genotype and vitamin B6: the association between vitamin B6 and adenomas seemed positive in TS 3R/3R individuals, but inverse in TS 2R/2R individuals. This study does not provide evidence for a role of SHMT1 genotype in adenoma occurrence. Future research has to indicate whether the TS-B6 interplay is a real effect or a chance finding.

AB - Thymidylate synthase and serine hydroxymethyltransferase are involved in folate metabolism. In a case-control study, including 768 cases and 709 controls, we investigated the associations between colorectal adenomas and TS tandem repeat and SHMT1 C1420T polymorphisms, and the interplay with B-vitamins. The polymorphisms were not associated with adenomas, but there was a borderline significant interaction between TS genotype and vitamin B6: the association between vitamin B6 and adenomas seemed positive in TS 3R/3R individuals, but inverse in TS 2R/2R individuals. This study does not provide evidence for a role of SHMT1 genotype in adenoma occurrence. Future research has to indicate whether the TS-B6 interplay is a real effect or a chance finding.

KW - promoter enhancer region

KW - plasma folate

KW - cancer

KW - gene

KW - metabolism

KW - methionine

KW - genotype

U2 - 10.1016/j.canlet.2006.10.002

DO - 10.1016/j.canlet.2006.10.002

M3 - Article

VL - 250

SP - 146

EP - 153

JO - Cancer Letters

JF - Cancer Letters

SN - 0304-3835

IS - 1

ER -