Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 2523-2533 |
| Journal | American Journal of Transplantation |
| Volume | 18 |
| Issue number | 10 |
| Early online date | 21 Feb 2018 |
| DOIs | |
| Publication status | Published - Oct 2018 |
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Keywords
- Clinical research/practice
- Graft survival
- Kidney transplantation/nephrology
- Nutrition
- Patient survival
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Dietary Approach to Stop Hypertension (DASH) diet and risk of renal function decline and all-cause mortality in renal transplant recipients. / Osté, Maryse C.J.; Gomes-Neto, António W.; Corpeleijn, Eva; Gans, Rijk O.B.; de Borst, Martin H.; van den Berg, Else; Soedamah-Muthu, Sabita S.; Kromhout, Daan; Navis, Gerjan J.; Bakker, Stephan J.L.
In: American Journal of Transplantation, Vol. 18, No. 10, 10.2018, p. 2523-2533.Research output: Contribution to journal › Article › Academic › peer-review
TY - JOUR
T1 - Dietary Approach to Stop Hypertension (DASH) diet and risk of renal function decline and all-cause mortality in renal transplant recipients
AU - Osté, Maryse C.J.
AU - Gomes-Neto, António W.
AU - Corpeleijn, Eva
AU - Gans, Rijk O.B.
AU - de Borst, Martin H.
AU - van den Berg, Else
AU - Soedamah-Muthu, Sabita S.
AU - Kromhout, Daan
AU - Navis, Gerjan J.
AU - Bakker, Stephan J.L.
PY - 2018/10
Y1 - 2018/10
N2 - Renal transplant recipients (RTR) are at risk of decline of graft function and premature mortality, with high blood pressure as an important risk factor for both. To study the association of the Dietary Approach to Stop Hypertension (DASH) diet with these adverse events, we conducted a prospective cohort study of adult RTR. Dietary data were collected using a validated 177-item food frequency questionnaire and an overall DASH-score was obtained. We included 632 stable RTR (mean ± standard deviation age 53.0 ± 12.7 years, 57% men). Mean DASH score was 23.8 ± 4.7. During median follow-up of 5.3 (interquartile range, 4.1-6.0) years, 119 (18.8%) RTR had renal function decline, defined as a combined endpoint of doubling of serum creatinine and death-censored graft failure, and 128 (20.3%) died. In Cox-regression analyses, RTR in the highest tertile of the DASH score had lower risk of both renal function decline (hazard ratio [HR] = 0.57; 95% confidence interval [CI], 0.33-0.96, P = .03) and all-cause mortality (HR = 0.52; 95%CI, 0.32-0.83, P = .006) compared to the lowest tertile, independent of potential confounders. Adherence to a DASH-style diet is associated with lower risk of both renal function decline and all-cause mortality. These results suggest that a healthful diet might benefit long-term outcome in RTR.
AB - Renal transplant recipients (RTR) are at risk of decline of graft function and premature mortality, with high blood pressure as an important risk factor for both. To study the association of the Dietary Approach to Stop Hypertension (DASH) diet with these adverse events, we conducted a prospective cohort study of adult RTR. Dietary data were collected using a validated 177-item food frequency questionnaire and an overall DASH-score was obtained. We included 632 stable RTR (mean ± standard deviation age 53.0 ± 12.7 years, 57% men). Mean DASH score was 23.8 ± 4.7. During median follow-up of 5.3 (interquartile range, 4.1-6.0) years, 119 (18.8%) RTR had renal function decline, defined as a combined endpoint of doubling of serum creatinine and death-censored graft failure, and 128 (20.3%) died. In Cox-regression analyses, RTR in the highest tertile of the DASH score had lower risk of both renal function decline (hazard ratio [HR] = 0.57; 95% confidence interval [CI], 0.33-0.96, P = .03) and all-cause mortality (HR = 0.52; 95%CI, 0.32-0.83, P = .006) compared to the lowest tertile, independent of potential confounders. Adherence to a DASH-style diet is associated with lower risk of both renal function decline and all-cause mortality. These results suggest that a healthful diet might benefit long-term outcome in RTR.
KW - Clinical research/practice
KW - Graft survival
KW - Kidney transplantation/nephrology
KW - Nutrition
KW - Patient survival
U2 - 10.1111/ajt.14707
DO - 10.1111/ajt.14707
M3 - Article
VL - 18
SP - 2523
EP - 2533
JO - American Journal of Transplantation
JF - American Journal of Transplantation
SN - 1600-6135
IS - 10
ER -