Dietary antioxidant compounds and liver health

Paola Vitaglione, Filomena Morisco, Nicola Caporaso, Vincenzo Fogliano*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

238 Citations (Scopus)

Abstract

Chronic liver damage is a widespread pathology characterized by a progressive evolution from steatosis to chronic hepatitis, fibrosis, cirrhosis, and hepatocellular carcinoma. As the oxidative stress plays a central role in liver diseases pathogenesis and progression, the use of antioxidants have been proposed as therapeutic agents, as well as drug coadjuvants, to counteract liver damage. In this work in vitro and in vivo studies, with emphasis on humans and animals experiments, have been considered and reviewed according to antioxidant typologies. Great differences emerge as far as ingested doses, bioavailability and liver ability to accumulate the various compounds. Results available up to now suggest that lycopene-rich foods could be proposed in therapeutic treatment of some liver pathologies. On the other hand contradictory results have been obtained with α-tocopherol, β-carotene and trans-resveratrol. Quercetin, silymarin, esculetin and thyme and rosemary among phenolic compounds need further studies.

Original languageEnglish
Pages (from-to)575-586
Number of pages12
JournalCritical Reviews in Food Science and Nutrition
Volume44
Issue number7-8
DOIs
Publication statusPublished - 17 Dec 2004
Externally publishedYes

Keywords

  • α-Tocopherol
  • Antioxidants
  • Carotenoids
  • Liver
  • Phenolic compounds
  • Resveratrol

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