Diet quality and markers of endothelial function: The CARDIA study

F.P.C. Sijtsma, K.A. Meyer, L.M. Steffen, L. van Horn, J.M. Shikany, A.O. Odegaard, M.D. Gross, D. Kromhout, D.R. Jacobs

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Abstract

Background and aim: Dietary patterns are associated cross-sectionally with cellular adhesion molecules (CAMs). We studied prospective associations of three dietary patterns with CAMs. Methods and results: In the Coronary Artery Risk Development in Young Adults (CARDIA) study, diet was assessed at years 0 (1985-86) and 7 (1992-93) examinations. Four circulating CAMs (E-selectin, P-selectin, soluble intercellular adhesion molecule 1 (sICAM-1), and vascular cellular adhesion molecule (VCAM)) were assayed at years 7 and 15 (2000-01). We created one index score "A Priori Diet Quality Score" and derived dietary patterns using principal components analysis (PCA). Multivariable linear regression models predicted year 15 CAMs from averaged (year 0/7) dietary patterns. The A Priori Diet Quality Score rated 46 food groups beneficial, neutral or adverse based on hypothesized health effects. We derived two PCA dietary patterns: "fruit and vegetables (FV)" (high intakes of fruit, vegetables, and whole grains) and "meat" (high intakes of red meat, refined grain, and butter). All dietary patterns were related to E-selectin and sICAM-1. P-selectin was not related to the FV dietary pattern. VCAM was only related to the A Priori Diet Quality Score. Strongest associations were for the meat dietary pattern with E-selectin (effect size 28% of an SD (+3.9/13.7 ng/mL)) and P-selectin (effect size 37% of an SD (+4.1/11.2 ng/mL)) and the A Priori Diet Quality Score with sICAM-1 (effect size 34% of an SD (-15.1/44.7 ng/mL)) and VCAM (effect size of 26% of an SD (-45.1/170.3 ng/mL)). Conclusion: This prospective analysis suggests that dietary patterns are associated with CAMs. (C) 2014 Elsevier B. V. All rights reserved.
Original languageEnglish
Pages (from-to)632-638
JournalNutrition, Metabolism & Cardiovascular Diseases
Volume24
Issue number6
DOIs
Publication statusPublished - 2014

Keywords

  • cardiovascular-disease risk
  • plasma-concentrations
  • atherosclerosis mesa
  • young-adults
  • inflammation
  • patterns
  • dysfunction
  • biomarkers
  • men

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    Sijtsma, F. P. C., Meyer, K. A., Steffen, L. M., van Horn, L., Shikany, J. M., Odegaard, A. O., Gross, M. D., Kromhout, D., & Jacobs, D. R. (2014). Diet quality and markers of endothelial function: The CARDIA study. Nutrition, Metabolism & Cardiovascular Diseases, 24(6), 632-638. https://doi.org/10.1016/j.numecd.2013.12.010