Diagnostic and Vaccination Approaches for Newcastle Disease Virus in Poultry

The Current and Emerging Perspectives

Muhammad Bashir Bello, Khatijah Yusoff, Aini Ideris, Mohd Hair-Bejo, Ben P.H. Peeters, Abdul Rahman Omar*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Scopus)

Abstract

Newcastle disease (ND) is one of the most devastating diseases that considerably cripple the global poultry industry. Because of its enormous socioeconomic importance and potential to rapidly spread to naïve birds in the vicinity, ND is included among the list of avian diseases that must be notified to the OIE immediately upon recognition. Currently, virus isolation followed by its serological or molecular identification is regarded as the gold standard method of ND diagnosis. However, this method is generally slow and requires specialised laboratory with biosafety containment facilities, making it of little relevance under epidemic situations where rapid diagnosis is seriously needed. Thus, molecular based diagnostics have evolved to overcome some of these difficulties, but the extensive genetic diversity of the virus ensures that isolates with mutations at the primer/probe binding sites escape detection using these assays. This diagnostic dilemma leads to the emergence of cutting-edge technologies such as next-generation sequencing (NGS) which have so far proven to be promising in terms of rapid, sensitive, and accurate recognition of virulent Newcastle disease virus (NDV) isolates even in mixed infections. As regards disease control strategies, conventional ND vaccines have stood the test of time by demonstrating track record of protective efficacy in the last 60 years. However, these vaccines are unable to block the replication and shedding of most of the currently circulating phylogenetically divergent virulent NDV isolates. Hence, rationally designed vaccines targeting the prevailing genotypes, the so-called genotype-matched vaccines, are highly needed to overcome these vaccination related challenges. Among the recently evolving technologies for the development of genotype-matched vaccines, reverse genetics-based live attenuated vaccines obviously appeared to be the most promising candidates. In this review, a comprehensive description of the current and emerging trends in the detection, identification, and control of ND in poultry are provided. The strengths and weaknesses of each of those techniques are also emphasised.

Original languageEnglish
Article number7278459
Number of pages18
JournalBioMed Research International
Volume2018
DOIs
Publication statusPublished - 5 Aug 2018

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Newcastle Disease
Newcastle disease virus
Poultry
Viruses
Vaccination
Vaccines
Genotype
Bird Diseases
Technology
Reverse Genetics
Attenuated Vaccines
Molecular Pathology
Coinfection
Birds
Industry
Disease control
Binding Sites
Mutation
Assays

Cite this

Bello, Muhammad Bashir ; Yusoff, Khatijah ; Ideris, Aini ; Hair-Bejo, Mohd ; Peeters, Ben P.H. ; Omar, Abdul Rahman. / Diagnostic and Vaccination Approaches for Newcastle Disease Virus in Poultry : The Current and Emerging Perspectives. In: BioMed Research International. 2018 ; Vol. 2018.
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abstract = "Newcastle disease (ND) is one of the most devastating diseases that considerably cripple the global poultry industry. Because of its enormous socioeconomic importance and potential to rapidly spread to na{\"i}ve birds in the vicinity, ND is included among the list of avian diseases that must be notified to the OIE immediately upon recognition. Currently, virus isolation followed by its serological or molecular identification is regarded as the gold standard method of ND diagnosis. However, this method is generally slow and requires specialised laboratory with biosafety containment facilities, making it of little relevance under epidemic situations where rapid diagnosis is seriously needed. Thus, molecular based diagnostics have evolved to overcome some of these difficulties, but the extensive genetic diversity of the virus ensures that isolates with mutations at the primer/probe binding sites escape detection using these assays. This diagnostic dilemma leads to the emergence of cutting-edge technologies such as next-generation sequencing (NGS) which have so far proven to be promising in terms of rapid, sensitive, and accurate recognition of virulent Newcastle disease virus (NDV) isolates even in mixed infections. As regards disease control strategies, conventional ND vaccines have stood the test of time by demonstrating track record of protective efficacy in the last 60 years. However, these vaccines are unable to block the replication and shedding of most of the currently circulating phylogenetically divergent virulent NDV isolates. Hence, rationally designed vaccines targeting the prevailing genotypes, the so-called genotype-matched vaccines, are highly needed to overcome these vaccination related challenges. Among the recently evolving technologies for the development of genotype-matched vaccines, reverse genetics-based live attenuated vaccines obviously appeared to be the most promising candidates. In this review, a comprehensive description of the current and emerging trends in the detection, identification, and control of ND in poultry are provided. The strengths and weaknesses of each of those techniques are also emphasised.",
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Diagnostic and Vaccination Approaches for Newcastle Disease Virus in Poultry : The Current and Emerging Perspectives. / Bello, Muhammad Bashir; Yusoff, Khatijah; Ideris, Aini; Hair-Bejo, Mohd; Peeters, Ben P.H.; Omar, Abdul Rahman.

In: BioMed Research International, Vol. 2018, 7278459, 05.08.2018.

Research output: Contribution to journalArticleAcademicpeer-review

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AU - Bello, Muhammad Bashir

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AU - Peeters, Ben P.H.

AU - Omar, Abdul Rahman

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