Abstract
Generating new carbon-carbon (C-C) bonds in an enantioselective way is one of the big challenges in organic synthesis. Aldolases are a natural tool for stereoselective C-C bond formation in a green and sustainable way. This review will focus on thermophilic aldolases in general and on dihydroxyacetone phosphate-dependent aldolases in particular. Biochemical properties and applications for synthesis of rare sugars and carbohydrates will be discussed
Original language | English |
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Pages (from-to) | 1-13 |
Journal | Extremophiles |
Volume | 18 |
Issue number | 1 |
DOIs | |
Publication status | Published - 2014 |
Keywords
- l-threonine aldolase
- stereochemically complementary biocatalysts
- ii fructose-1,6-bisphosphate aldolase
- thermus-thermophilus hb8
- escherichia-coli
- d-fructose-6-phosphate aldolase
- directed evolution
- crystal-structure
- active-site
- l-rhamnulose-1-phosp