DHAP-dependent aldolases from (hyper)thermophiles: biochemistry and applications

P. Falcicchio, S. Wolterink-van Loo, M.C.R. Franssen, J. van der Oost

Research output: Contribution to journalArticleAcademicpeer-review

15 Citations (Scopus)


Generating new carbon-carbon (C-C) bonds in an enantioselective way is one of the big challenges in organic synthesis. Aldolases are a natural tool for stereoselective C-C bond formation in a green and sustainable way. This review will focus on thermophilic aldolases in general and on dihydroxyacetone phosphate-dependent aldolases in particular. Biochemical properties and applications for synthesis of rare sugars and carbohydrates will be discussed
Original languageEnglish
Pages (from-to)1-13
Issue number1
Publication statusPublished - 2014


  • l-threonine aldolase
  • stereochemically complementary biocatalysts
  • ii fructose-1,6-bisphosphate aldolase
  • thermus-thermophilus hb8
  • escherichia-coli
  • d-fructose-6-phosphate aldolase
  • directed evolution
  • crystal-structure
  • active-site
  • l-rhamnulose-1-phosp

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