Abstract
Selective Androgen Receptor Modulators (SARMs) are nonendogenous compounds that have similar anabolic properties to anabolic steroids. All SARMs are to this date investigational drugs, since no SARMs have passed clinical trials or are approved as human/veterinary drugs. During a police raid back in 2020, an illegal production laboratory actively producing SARMs was discovered, which
led to a gained interest in these compounds regarding food safety.
Due to the affordability, availability, and steroid-like effects, the use of
SARMs in animal husbandry cannot be excluded. However, currently
many of these SARMs are not actively monitored and are often not yet
included in routine methods. Therefore, we set to develop a liquid
chromatography tandem-mass spectrometry (UHPLC-MS/MS) method
to detect SARMs in relevant animal matrices. As only limited
information is available regarding metabolism and pharmacokinetics of
these SARMs, two methods were developed for 1) bovine and porcine
urine and 2) bovine hair. The urine method was successfully applied to incurred bovine urine samples.
led to a gained interest in these compounds regarding food safety.
Due to the affordability, availability, and steroid-like effects, the use of
SARMs in animal husbandry cannot be excluded. However, currently
many of these SARMs are not actively monitored and are often not yet
included in routine methods. Therefore, we set to develop a liquid
chromatography tandem-mass spectrometry (UHPLC-MS/MS) method
to detect SARMs in relevant animal matrices. As only limited
information is available regarding metabolism and pharmacokinetics of
these SARMs, two methods were developed for 1) bovine and porcine
urine and 2) bovine hair. The urine method was successfully applied to incurred bovine urine samples.
Original language | English |
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Number of pages | 1 |
Publication status | Published - 23 May 2022 |
Event | EuroResidue Conference IX 2022 - Hotel de Ruwenberg, St. Michielsgestel, Netherlands Duration: 23 May 2022 → 25 May 2022 https://www.euroresidue.eu/ |
Conference/symposium
Conference/symposium | EuroResidue Conference IX 2022 |
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Country/Territory | Netherlands |
City | St. Michielsgestel |
Period | 23/05/22 → 25/05/22 |
Internet address |