Development and validation of a new in vitro assay for selection of probiotic bacteria that express immunestimulating properties in chickens in vivo

Marjorie E. Koenen, Remy van der Hulst, Mariska Leering, Suzan H.M. Jeurissen, Wim J.A. Boersma

    Research output: Contribution to journalArticleAcademicpeer-review

    27 Citations (Scopus)

    Abstract

    Oral administration of immunoprobiotic bacteria may support animal health. Species specificity of such microorganisms requires appropriate selection. An in vitro assay for the selection of immunoprobiotic lactic acid bacteria was developed in chicken. The assay allowed testing of large numbers of individual strains. Immune stimulation in vitro correlated well with the in vivo situation in two experiments and no false negative results occurred. Therefore this assay is an appropriate selection tool for immunomodulating properties of lactic acid bacteria in chicken. (C) 2003 Federation of European Microbiological Societies. Published by Elsevier B.V. All rights reserved.
    Original languageEnglish
    Pages (from-to)119-127
    JournalFEMS Immunology and Medical Microbiology
    Volume40
    Issue number2
    DOIs
    Publication statusPublished - 2004

    Keywords

    • Chicken
    • Immunomodulation
    • In vitro assay
    • Lactic acid bacterium
    • Lymphocyte proliferation
    • Probiotic

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