Development and body mass inversely affect children's brain activation in dorsolateral prefrontal cortex during food choice

, Floor van Meer, Laura N. van der Laan, Gabriele Eiben, Lauren Lissner, Maike Wolters, Stefan Rach, Manfred Herrmann, Peter Erhard, Denes Molnar, Gergely Orsi, Max A. Viergever, Roger A.H. Adan, Paul A.M. Smeets

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Childhood obesity is a rising problem caused in part by unhealthy food choices. Food choices are based on a neural value signal encoded in the ventromedial prefrontal cortex, and self-control involves modulation of this signal by the dorsolateral prefrontal cortex (dlPFC). We determined the effects of development, body mass (BMI Cole score) and body mass history on the neural correlates of healthy food choice in children. 141 children (aged 10-17y) from Germany, Hungary and Sweden were scanned with fMRI while performing a food choice task. Afterwards health and taste ratings of the foods were collected. In the food choice task children were asked to consider the healthiness or tastiness of the food or to choose naturally. Overall, children made healthier choices when asked to consider healthiness. However, children who had a higher weight gain per year chose less healthy foods when considering healthiness but not when choosing naturally. Pubertal development stage correlated positively while current body mass correlated negatively with dlPFC activation when accepting foods. Pubertal development negatively and current body mass positively influenced the effect of considering healthiness on activation of brain areas involved in salience and motivation. In conclusion, children in earlier stages of pubertal development and children with a higher body weight exhibited less activation in the dlPFC, which has been implicated in self-control during food choice. Furthermore, pubertal development and body mass influenced neural responses to a health cue in areas involved in salience and motivation. Thus, these findings suggest that children in earlier stages of pubertal development, children with a higher body mass gain and children with overweight may possibly be less susceptible to healthy eating interventions that rely on self-control or that highlight health aspects of food.

LanguageEnglish
Article number116016
JournalNeuroImage
Volume201
DOIs
Publication statusPublished - 1 Nov 2019

Fingerprint

Prefrontal Cortex
Food
Brain
Child Development
Motivation
Health
Hungary
Pediatric Obesity
Sweden
Weight Gain
Cues
Germany
History
Body Weight
Magnetic Resonance Imaging

Keywords

  • Decision making
  • Development
  • fMRI
  • Food choice
  • Overweight

Cite this

@article{8c013c35619e4e5591bc5c3067aa7831,
title = "Development and body mass inversely affect children's brain activation in dorsolateral prefrontal cortex during food choice",
abstract = "Childhood obesity is a rising problem caused in part by unhealthy food choices. Food choices are based on a neural value signal encoded in the ventromedial prefrontal cortex, and self-control involves modulation of this signal by the dorsolateral prefrontal cortex (dlPFC). We determined the effects of development, body mass (BMI Cole score) and body mass history on the neural correlates of healthy food choice in children. 141 children (aged 10-17y) from Germany, Hungary and Sweden were scanned with fMRI while performing a food choice task. Afterwards health and taste ratings of the foods were collected. In the food choice task children were asked to consider the healthiness or tastiness of the food or to choose naturally. Overall, children made healthier choices when asked to consider healthiness. However, children who had a higher weight gain per year chose less healthy foods when considering healthiness but not when choosing naturally. Pubertal development stage correlated positively while current body mass correlated negatively with dlPFC activation when accepting foods. Pubertal development negatively and current body mass positively influenced the effect of considering healthiness on activation of brain areas involved in salience and motivation. In conclusion, children in earlier stages of pubertal development and children with a higher body weight exhibited less activation in the dlPFC, which has been implicated in self-control during food choice. Furthermore, pubertal development and body mass influenced neural responses to a health cue in areas involved in salience and motivation. Thus, these findings suggest that children in earlier stages of pubertal development, children with a higher body mass gain and children with overweight may possibly be less susceptible to healthy eating interventions that rely on self-control or that highlight health aspects of food.",
keywords = "Decision making, Development, fMRI, Food choice, Overweight",
author = "{van Meer}, Floor and {van der Laan}, {Laura N.} and Gabriele Eiben and Lauren Lissner and Maike Wolters and Stefan Rach and Manfred Herrmann and Peter Erhard and Denes Molnar and Gergely Orsi and Viergever, {Max A.} and Adan, {Roger A.H.} and Smeets, {Paul A.M.}",
year = "2019",
month = "11",
day = "1",
doi = "10.1016/j.neuroimage.2019.116016",
language = "English",
volume = "201",
journal = "NeuroImage",
issn = "1053-8119",
publisher = "Elsevier",

}

Development and body mass inversely affect children's brain activation in dorsolateral prefrontal cortex during food choice. /.

In: NeuroImage, Vol. 201, 116016, 01.11.2019.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Development and body mass inversely affect children's brain activation in dorsolateral prefrontal cortex during food choice

AU - van Meer, Floor

AU - van der Laan, Laura N.

AU - Eiben, Gabriele

AU - Lissner, Lauren

AU - Wolters, Maike

AU - Rach, Stefan

AU - Herrmann, Manfred

AU - Erhard, Peter

AU - Molnar, Denes

AU - Orsi, Gergely

AU - Viergever, Max A.

AU - Adan, Roger A.H.

AU - Smeets, Paul A.M.

PY - 2019/11/1

Y1 - 2019/11/1

N2 - Childhood obesity is a rising problem caused in part by unhealthy food choices. Food choices are based on a neural value signal encoded in the ventromedial prefrontal cortex, and self-control involves modulation of this signal by the dorsolateral prefrontal cortex (dlPFC). We determined the effects of development, body mass (BMI Cole score) and body mass history on the neural correlates of healthy food choice in children. 141 children (aged 10-17y) from Germany, Hungary and Sweden were scanned with fMRI while performing a food choice task. Afterwards health and taste ratings of the foods were collected. In the food choice task children were asked to consider the healthiness or tastiness of the food or to choose naturally. Overall, children made healthier choices when asked to consider healthiness. However, children who had a higher weight gain per year chose less healthy foods when considering healthiness but not when choosing naturally. Pubertal development stage correlated positively while current body mass correlated negatively with dlPFC activation when accepting foods. Pubertal development negatively and current body mass positively influenced the effect of considering healthiness on activation of brain areas involved in salience and motivation. In conclusion, children in earlier stages of pubertal development and children with a higher body weight exhibited less activation in the dlPFC, which has been implicated in self-control during food choice. Furthermore, pubertal development and body mass influenced neural responses to a health cue in areas involved in salience and motivation. Thus, these findings suggest that children in earlier stages of pubertal development, children with a higher body mass gain and children with overweight may possibly be less susceptible to healthy eating interventions that rely on self-control or that highlight health aspects of food.

AB - Childhood obesity is a rising problem caused in part by unhealthy food choices. Food choices are based on a neural value signal encoded in the ventromedial prefrontal cortex, and self-control involves modulation of this signal by the dorsolateral prefrontal cortex (dlPFC). We determined the effects of development, body mass (BMI Cole score) and body mass history on the neural correlates of healthy food choice in children. 141 children (aged 10-17y) from Germany, Hungary and Sweden were scanned with fMRI while performing a food choice task. Afterwards health and taste ratings of the foods were collected. In the food choice task children were asked to consider the healthiness or tastiness of the food or to choose naturally. Overall, children made healthier choices when asked to consider healthiness. However, children who had a higher weight gain per year chose less healthy foods when considering healthiness but not when choosing naturally. Pubertal development stage correlated positively while current body mass correlated negatively with dlPFC activation when accepting foods. Pubertal development negatively and current body mass positively influenced the effect of considering healthiness on activation of brain areas involved in salience and motivation. In conclusion, children in earlier stages of pubertal development and children with a higher body weight exhibited less activation in the dlPFC, which has been implicated in self-control during food choice. Furthermore, pubertal development and body mass influenced neural responses to a health cue in areas involved in salience and motivation. Thus, these findings suggest that children in earlier stages of pubertal development, children with a higher body mass gain and children with overweight may possibly be less susceptible to healthy eating interventions that rely on self-control or that highlight health aspects of food.

KW - Decision making

KW - Development

KW - fMRI

KW - Food choice

KW - Overweight

U2 - 10.1016/j.neuroimage.2019.116016

DO - 10.1016/j.neuroimage.2019.116016

M3 - Article

VL - 201

JO - NeuroImage

T2 - NeuroImage

JF - NeuroImage

SN - 1053-8119

M1 - 116016

ER -