Development and application of an immunocompetent human induced pluripotent stem cell-derived intestinal epithelial cell model for hazard assessment of the oral exposure route

M. van der Zande; L.P.M. Duivenvoorde; B. Fabrizi; A.P. Vos; S. Bastiaan-Net; M.M.M. Tomassen; A.W.F. Janssen

doi:10.5281/zenodo.10890105

Development and application of an immunocompetent human induced pluripotent stem cell-derived intestinal epithelial cell model for hazard assessment of the oral exposure route

M. van der Zande, L.P.M. Duivenvoorde, B. Fabrizi, A.P. Vos, S. Bastiaan-Net, M.M.M. Tomassen, A.W.F. Janssen

Research output: Contribution to conference › Poster › Academic

Abstract

Human induced pluripotent stem cell (hiPSC)-derived intestinal epithelial cell (IEC) layers have the potential to provide an increasingly improved alternative to cell lines as they differentiate into multiple intestinal cell types that are also present in vivo. However, these models currently lack immunocompetence, as they do not contain immune cells like for instance dendritic cells (DCs) that play an important role in intestinal immune responses.

Original language	English
DOIs	https://doi.org/10.5281/zenodo.10890105
Publication status	Published - 10 Mar 2024
Event	The SOT 63rd Annual Meeting and ToxExpo - Salt Lake City, United States Duration: 10 Mar 2024 → 14 Mar 2024

Conference

Conference	The SOT 63rd Annual Meeting and ToxExpo
Abbreviated title	SOT 2024
Country/Territory	United States
City	Salt Lake City
Period	10/03/24 → 14/03/24

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10.5281/zenodo.10890105Licence: CC BY

https://edepot.wur.nl/670629Licence: CC BY

PlasticsFatE: Plastics fate and effects in the human body
1/04/21 → 31/03/25
Project: EU research project

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van der Zande, M., Duivenvoorde, L. P. M., Fabrizi, B., Vos, A. P., Bastiaan-Net, S., Tomassen, M. M. M., & Janssen, A. W. F. (2024). Development and application of an immunocompetent human induced pluripotent stem cell-derived intestinal epithelial cell model for hazard assessment of the oral exposure route. Poster session presented at The SOT 63rd Annual Meeting and ToxExpo, Salt Lake City, Utah, United States. https://doi.org/10.5281/zenodo.10890105

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abstract = "Human induced pluripotent stem cell (hiPSC)-derived intestinal epithelial cell (IEC) layers have the potential to provide an increasingly improved alternative to cell lines as they differentiate into multiple intestinal cell types that are also present in vivo. However, these models currently lack immunocompetence, as they do not contain immune cells like for instance dendritic cells (DCs) that play an important role in intestinal immune responses.",

author = "{van der Zande}, M. and L.P.M. Duivenvoorde and B. Fabrizi and A.P. Vos and S. Bastiaan-Net and M.M.M. Tomassen and A.W.F. Janssen",

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van der Zande, M , Duivenvoorde, LPM, Fabrizi, B, Vos, AP , Bastiaan-Net, S , Tomassen, MMM & Janssen, AWF 2024, 'Development and application of an immunocompetent human induced pluripotent stem cell-derived intestinal epithelial cell model for hazard assessment of the oral exposure route', The SOT 63rd Annual Meeting and ToxExpo, Salt Lake City, United States, 10/03/24 - 14/03/24. https://doi.org/10.5281/zenodo.10890105

Development and application of an immunocompetent human induced pluripotent stem cell-derived intestinal epithelial cell model for hazard assessment of the oral exposure route. / van der Zande, M.; Duivenvoorde, L.P.M.; Fabrizi, B. et al.
2024. Poster session presented at The SOT 63rd Annual Meeting and ToxExpo, Salt Lake City, Utah, United States.

Research output: Contribution to conference › Poster › Academic

TY - CONF

T1 - Development and application of an immunocompetent human induced pluripotent stem cell-derived intestinal epithelial cell model for hazard assessment of the oral exposure route

AU - van der Zande, M.

AU - Duivenvoorde, L.P.M.

AU - Fabrizi, B.

AU - Vos, A.P.

AU - Bastiaan-Net, S.

AU - Tomassen, M.M.M.

AU - Janssen, A.W.F.

PY - 2024/3/10

Y1 - 2024/3/10

N2 - Human induced pluripotent stem cell (hiPSC)-derived intestinal epithelial cell (IEC) layers have the potential to provide an increasingly improved alternative to cell lines as they differentiate into multiple intestinal cell types that are also present in vivo. However, these models currently lack immunocompetence, as they do not contain immune cells like for instance dendritic cells (DCs) that play an important role in intestinal immune responses.

AB - Human induced pluripotent stem cell (hiPSC)-derived intestinal epithelial cell (IEC) layers have the potential to provide an increasingly improved alternative to cell lines as they differentiate into multiple intestinal cell types that are also present in vivo. However, these models currently lack immunocompetence, as they do not contain immune cells like for instance dendritic cells (DCs) that play an important role in intestinal immune responses.

U2 - 10.5281/zenodo.10890105

DO - 10.5281/zenodo.10890105

M3 - Poster

T2 - The SOT 63rd Annual Meeting and ToxExpo

Y2 - 10 March 2024 through 14 March 2024

ER -

van der Zande M , Duivenvoorde LPM, Fabrizi B, Vos AP , Bastiaan-Net S , Tomassen MMM et al.. Development and application of an immunocompetent human induced pluripotent stem cell-derived intestinal epithelial cell model for hazard assessment of the oral exposure route. 2024. Poster session presented at The SOT 63rd Annual Meeting and ToxExpo, Salt Lake City, Utah, United States. doi: 10.5281/zenodo.10890105

Development and application of an immunocompetent human induced pluripotent stem cell-derived intestinal epithelial cell model for hazard assessment of the oral exposure route

Abstract

Conference

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PlasticsFatE: Plastics fate and effects in the human body

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