Determination of the Transport Efficiency in spICP-MS Analysis Using Conventional Sample Introduction Systems: An Interlaboratory Comparison Study

Otmar Geiss*, Ivana Bianchi, Guillaume Bucher, Eveline Verleysen, Frédéric Brassinne, Jan Mast, Katrin Loeschner, Lucas Givelet, Francesco Cubadda, Francesca Ferraris, Andrea Raggi, Francesca Iacoponi, Ruud Peters, Anna Undas, Alexandra Müller, Ann Katrin Meinhardt, Birgit Hetzer, Volker Gräf, Antonio R. Montoro Bustos, Josefa Barrero-Moreno

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

In single particle inductively coupled plasma mass spectrometry (spICP-MS), the transport efficiency is fundamental for the correct determination of both particle number concentration and size. In the present study, transport efficiency was systematically determined on three different days with six carefully characterised gold nanoparticle (AuNP) suspensions and in seven European and US expert laboratories using different ICP-MS instruments and spICP-MS software. Both particle size— (TES)—and particle frequency—(TEF)—methods were applied. The resulting transport efficiencies did not deviate much under ideal conditions. The TEF method however systematically resulted in lower transport efficiencies. The extent of this difference (0–300% rel. difference) depended largely on the choice and storage conditions of the nanoparticle suspensions used for the determination. The TES method is recommended when the principal measurement objective is particle size. If the main aim of the measurement is the determination of the particle number concentration, the TEF approach could be preferred as it might better account for particle losses in the sample introduction system.

Original languageEnglish
Article number725
JournalNanomaterials
Volume12
Issue number4
DOIs
Publication statusPublished - 21 Feb 2022

Keywords

  • Gold nanoparticles
  • Single particle ICP-MS
  • Transport efficiency

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