Detection of QTL for innate: Non-specific antibody levels binding LPS and LTA in two independent populations of laying hens

M.Z. Siwek; A.J. Buitenhuis; S.J.B. Cornelissen; M.G.B. Nieuwland; E.F. Knol; R.P.M.A. Crooijmans; M.A.M. Groenen; H.K. Parmentier; J.J. van der Poel

doi:10.1016/j.dci.2005.09.004

Detection of QTL for innate: Non-specific antibody levels binding LPS and LTA in two independent populations of laying hens

M.Z. Siwek, A.J. Buitenhuis, S.J.B. Cornelissen, M.G.B. Nieuwland, E.F. Knol, R.P.M.A. Crooijmans, M.A.M. Groenen, H.K. Parmentier, J.J. van der Poel

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Abstract

In the current study results are presented of an experiment dealing with the Natural antibodies which are measured by level of homotopes LPS and LTA. Two independent populations were examined (F2 population descendant from a cross between chickens divergently selected for either High or Low specific Ab responses to SRBC (HL) and F2 cross descendant from lines expressed different behavior concerning feather pecking (FP)). In total 12 QTL were detected to non-specific antibody titers directed to LTA and LPS and at two ages after applying two statistical models in an F2 HL population. Similarly in an FP cross overall seven QTL were detected. Based on obtained results it might be concluded that different QTL regions are associated with immune responses to homotopes LPS and LTA in poultry

Original language	English
Pages (from-to)	659-666
Journal	Developmental and Comparative Immunology
Volume	30
Issue number	7
DOIs	https://doi.org/10.1016/j.dci.2005.09.004
Publication status	Published - 2006

Keywords

quantitative trait loci
red-blood-cells
natural antibodies
immune-responses
chicken genome
acid
autoantibodies
hemocyanin
bacteria
crosses

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10.1016/j.dci.2005.09.004

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Siwek, M. Z., Buitenhuis, A. J., Cornelissen, S. J. B., Nieuwland, M. G. B., Knol, E. F., Crooijmans, R. P. M. A., Groenen, M. A. M., Parmentier, H. K., & van der Poel, J. J. (2006). Detection of QTL for innate: Non-specific antibody levels binding LPS and LTA in two independent populations of laying hens. Developmental and Comparative Immunology, 30(7), 659-666. https://doi.org/10.1016/j.dci.2005.09.004

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title = "Detection of QTL for innate: Non-specific antibody levels binding LPS and LTA in two independent populations of laying hens",

abstract = "In the current study results are presented of an experiment dealing with the Natural antibodies which are measured by level of homotopes LPS and LTA. Two independent populations were examined (F2 population descendant from a cross between chickens divergently selected for either High or Low specific Ab responses to SRBC (HL) and F2 cross descendant from lines expressed different behavior concerning feather pecking (FP)). In total 12 QTL were detected to non-specific antibody titers directed to LTA and LPS and at two ages after applying two statistical models in an F2 HL population. Similarly in an FP cross overall seven QTL were detected. Based on obtained results it might be concluded that different QTL regions are associated with immune responses to homotopes LPS and LTA in poultry",

keywords = "quantitative trait loci, red-blood-cells, natural antibodies, immune-responses, chicken genome, acid, autoantibodies, hemocyanin, bacteria, crosses",

author = "M.Z. Siwek and A.J. Buitenhuis and S.J.B. Cornelissen and M.G.B. Nieuwland and E.F. Knol and R.P.M.A. Crooijmans and M.A.M. Groenen and H.K. Parmentier and {van der Poel}, J.J.",

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doi = "10.1016/j.dci.2005.09.004",

language = "English",

volume = "30",

pages = "659--666",

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Siwek, MZ, Buitenhuis, AJ, Cornelissen, SJB, Nieuwland, MGB, Knol, EF, Crooijmans, RPMA , Groenen, MAM, Parmentier, HK & van der Poel, JJ 2006, 'Detection of QTL for innate: Non-specific antibody levels binding LPS and LTA in two independent populations of laying hens', Developmental and Comparative Immunology, vol. 30, no. 7, pp. 659-666. https://doi.org/10.1016/j.dci.2005.09.004

TY - JOUR

T1 - Detection of QTL for innate: Non-specific antibody levels binding LPS and LTA in two independent populations of laying hens

AU - Siwek, M.Z.

AU - Buitenhuis, A.J.

AU - Cornelissen, S.J.B.

AU - Nieuwland, M.G.B.

AU - Knol, E.F.

AU - Crooijmans, R.P.M.A.

AU - Groenen, M.A.M.

AU - Parmentier, H.K.

AU - van der Poel, J.J.

PY - 2006

Y1 - 2006

N2 - In the current study results are presented of an experiment dealing with the Natural antibodies which are measured by level of homotopes LPS and LTA. Two independent populations were examined (F2 population descendant from a cross between chickens divergently selected for either High or Low specific Ab responses to SRBC (HL) and F2 cross descendant from lines expressed different behavior concerning feather pecking (FP)). In total 12 QTL were detected to non-specific antibody titers directed to LTA and LPS and at two ages after applying two statistical models in an F2 HL population. Similarly in an FP cross overall seven QTL were detected. Based on obtained results it might be concluded that different QTL regions are associated with immune responses to homotopes LPS and LTA in poultry

AB - In the current study results are presented of an experiment dealing with the Natural antibodies which are measured by level of homotopes LPS and LTA. Two independent populations were examined (F2 population descendant from a cross between chickens divergently selected for either High or Low specific Ab responses to SRBC (HL) and F2 cross descendant from lines expressed different behavior concerning feather pecking (FP)). In total 12 QTL were detected to non-specific antibody titers directed to LTA and LPS and at two ages after applying two statistical models in an F2 HL population. Similarly in an FP cross overall seven QTL were detected. Based on obtained results it might be concluded that different QTL regions are associated with immune responses to homotopes LPS and LTA in poultry

KW - quantitative trait loci

KW - red-blood-cells

KW - natural antibodies

KW - immune-responses

KW - chicken genome

KW - acid

KW - autoantibodies

KW - hemocyanin

KW - bacteria

KW - crosses

U2 - 10.1016/j.dci.2005.09.004

DO - 10.1016/j.dci.2005.09.004

M3 - Article

SN - 0145-305X

VL - 30

SP - 659

EP - 666

JO - Developmental and Comparative Immunology

JF - Developmental and Comparative Immunology

IS - 7

ER -

Detection of QTL for innate: Non-specific antibody levels binding LPS and LTA in two independent populations of laying hens

Abstract

Keywords

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