Detection of QTL for innate: Non-specific antibody levels binding LPS and LTA in two independent populations of laying hens

M.Z. Siwek, A.J. Buitenhuis, S.J.B. Cornelissen, M.G.B. Nieuwland, E.F. Knol, R.P.M.A. Crooijmans, M.A.M. Groenen, H.K. Parmentier, J.J. van der Poel

Research output: Contribution to journalArticleAcademicpeer-review

25 Citations (Scopus)

Abstract

In the current study results are presented of an experiment dealing with the Natural antibodies which are measured by level of homotopes LPS and LTA. Two independent populations were examined (F2 population descendant from a cross between chickens divergently selected for either High or Low specific Ab responses to SRBC (HL) and F2 cross descendant from lines expressed different behavior concerning feather pecking (FP)). In total 12 QTL were detected to non-specific antibody titers directed to LTA and LPS and at two ages after applying two statistical models in an F2 HL population. Similarly in an FP cross overall seven QTL were detected. Based on obtained results it might be concluded that different QTL regions are associated with immune responses to homotopes LPS and LTA in poultry
Original languageEnglish
Pages (from-to)659-666
JournalDevelopmental and Comparative Immunology
Volume30
Issue number7
DOIs
Publication statusPublished - 2006

Keywords

  • quantitative trait loci
  • red-blood-cells
  • natural antibodies
  • immune-responses
  • chicken genome
  • acid
  • autoantibodies
  • hemocyanin
  • bacteria
  • crosses

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