Detection of QTL for innate: Non-specific antibody levels binding LPS and LTA in two independent populations of laying hens

M.Z. Siwek, A.J. Buitenhuis, S.J.B. Cornelissen, M.G.B. Nieuwland, E.F. Knol, R.P.M.A. Crooijmans, M.A.M. Groenen, H.K. Parmentier, J.J. van der Poel

Research output: Contribution to journalArticleAcademicpeer-review

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Abstract

In the current study results are presented of an experiment dealing with the Natural antibodies which are measured by level of homotopes LPS and LTA. Two independent populations were examined (F2 population descendant from a cross between chickens divergently selected for either High or Low specific Ab responses to SRBC (HL) and F2 cross descendant from lines expressed different behavior concerning feather pecking (FP)). In total 12 QTL were detected to non-specific antibody titers directed to LTA and LPS and at two ages after applying two statistical models in an F2 HL population. Similarly in an FP cross overall seven QTL were detected. Based on obtained results it might be concluded that different QTL regions are associated with immune responses to homotopes LPS and LTA in poultry
Original languageEnglish
Pages (from-to)659-666
JournalDevelopmental and Comparative Immunology
Volume30
Issue number7
DOIs
Publication statusPublished - 2006

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Feathers
Antibodies
Population
Statistical Models
Poultry
Chickens

Keywords

  • quantitative trait loci
  • red-blood-cells
  • natural antibodies
  • immune-responses
  • chicken genome
  • acid
  • autoantibodies
  • hemocyanin
  • bacteria
  • crosses

Cite this

Siwek, M.Z. ; Buitenhuis, A.J. ; Cornelissen, S.J.B. ; Nieuwland, M.G.B. ; Knol, E.F. ; Crooijmans, R.P.M.A. ; Groenen, M.A.M. ; Parmentier, H.K. ; van der Poel, J.J. / Detection of QTL for innate: Non-specific antibody levels binding LPS and LTA in two independent populations of laying hens. In: Developmental and Comparative Immunology. 2006 ; Vol. 30, No. 7. pp. 659-666.
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abstract = "In the current study results are presented of an experiment dealing with the Natural antibodies which are measured by level of homotopes LPS and LTA. Two independent populations were examined (F2 population descendant from a cross between chickens divergently selected for either High or Low specific Ab responses to SRBC (HL) and F2 cross descendant from lines expressed different behavior concerning feather pecking (FP)). In total 12 QTL were detected to non-specific antibody titers directed to LTA and LPS and at two ages after applying two statistical models in an F2 HL population. Similarly in an FP cross overall seven QTL were detected. Based on obtained results it might be concluded that different QTL regions are associated with immune responses to homotopes LPS and LTA in poultry",
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Detection of QTL for innate: Non-specific antibody levels binding LPS and LTA in two independent populations of laying hens. / Siwek, M.Z.; Buitenhuis, A.J.; Cornelissen, S.J.B.; Nieuwland, M.G.B.; Knol, E.F.; Crooijmans, R.P.M.A.; Groenen, M.A.M.; Parmentier, H.K.; van der Poel, J.J.

In: Developmental and Comparative Immunology, Vol. 30, No. 7, 2006, p. 659-666.

Research output: Contribution to journalArticleAcademicpeer-review

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T1 - Detection of QTL for innate: Non-specific antibody levels binding LPS and LTA in two independent populations of laying hens

AU - Siwek, M.Z.

AU - Buitenhuis, A.J.

AU - Cornelissen, S.J.B.

AU - Nieuwland, M.G.B.

AU - Knol, E.F.

AU - Crooijmans, R.P.M.A.

AU - Groenen, M.A.M.

AU - Parmentier, H.K.

AU - van der Poel, J.J.

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AB - In the current study results are presented of an experiment dealing with the Natural antibodies which are measured by level of homotopes LPS and LTA. Two independent populations were examined (F2 population descendant from a cross between chickens divergently selected for either High or Low specific Ab responses to SRBC (HL) and F2 cross descendant from lines expressed different behavior concerning feather pecking (FP)). In total 12 QTL were detected to non-specific antibody titers directed to LTA and LPS and at two ages after applying two statistical models in an F2 HL population. Similarly in an FP cross overall seven QTL were detected. Based on obtained results it might be concluded that different QTL regions are associated with immune responses to homotopes LPS and LTA in poultry

KW - quantitative trait loci

KW - red-blood-cells

KW - natural antibodies

KW - immune-responses

KW - chicken genome

KW - acid

KW - autoantibodies

KW - hemocyanin

KW - bacteria

KW - crosses

U2 - 10.1016/j.dci.2005.09.004

DO - 10.1016/j.dci.2005.09.004

M3 - Article

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JO - Developmental and Comparative Immunology

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