Detection of candidate regions affecting bovine IgM natural antibodies in milk

Juan Cordero Solorzano; J.A.J. Arts; H.K. Parmentier; H. Bovenhuis

Detection of candidate regions affecting bovine IgM natural antibodies in milk

Juan Cordero Solorzano, J.A.J. Arts, H.K. Parmentier, H. Bovenhuis

Research output: Chapter in Book/Report/Conference proceeding › Conference paper › Academic

Abstract

Two genomic regions were found to be associated with IgM antibody titers in milk binding lipoteichoic acid (LTA); one on chromosome 17 and the other on chromosome 21. Phenotypes were measured by ELISA and genotypes consisted of imputed 777k SNP. Single SNP analyses were run using an animal model to retrieve significant SNP. In BTA21, a gene for the heavy chains of immunoglobulins, IGHV is proposed as a candidate gene as was true for VPREB3 in BTA17 related to B-cell maturation. These findings provide a further step in better understanding the genetic background of natural antibodies (NAbs), that may be relevant for relevant for the estimation of dairy cattle health. Keywords: dairy cattle, natural antibodies, genome-wide association

Original language	English
Title of host publication	Proceedings of the World Congress on Genetics Applied to Livestock Production
Subtitle of host publication	Volume Biology - Disease Resistance 1
Publisher	WCGALP
Number of pages	8
Publication status	Published - Feb 2018
Event	11th World Congress on Genetics Applied to Livestock Production - Auckland, New Zealand Duration: 11 Feb 2018 → 16 Feb 2018

Conference

Conference	11th World Congress on Genetics Applied to Livestock Production
Country/Territory	New Zealand
City	Auckland
Period	11/02/18 → 16/02/18

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http://www.wcgalp.org/proceedings/2018/detection-candidate-regions-affecting-bovine-igm-natural-antibodies-milkLicence: CC BY-NC-ND

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Cordero Solorzano, J., Arts, J. A. J., Parmentier, H. K., & Bovenhuis, H. (2018). Detection of candidate regions affecting bovine IgM natural antibodies in milk. In Proceedings of the World Congress on Genetics Applied to Livestock Production: Volume Biology - Disease Resistance 1 [559] WCGALP. http://www.wcgalp.org/proceedings/2018/detection-candidate-regions-affecting-bovine-igm-natural-antibodies-milk

@inproceedings{20c58a3f23fe4f2a893d5e2af6e939c7,

title = "Detection of candidate regions affecting bovine IgM natural antibodies in milk",

abstract = "Two genomic regions were found to be associated with IgM antibody titers in milk binding lipoteichoic acid (LTA); one on chromosome 17 and the other on chromosome 21. Phenotypes were measured by ELISA and genotypes consisted of imputed 777k SNP. Single SNP analyses were run using an animal model to retrieve significant SNP. In BTA21, a gene for the heavy chains of immunoglobulins, IGHV is proposed as a candidate gene as was true for VPREB3 in BTA17 related to B-cell maturation. These findings provide a further step in better understanding the genetic background of natural antibodies (NAbs), that may be relevant for relevant for the estimation of dairy cattle health. Keywords: dairy cattle, natural antibodies, genome-wide association",

author = "{Cordero Solorzano}, Juan and J.A.J. Arts and H.K. Parmentier and H. Bovenhuis",

year = "2018",

month = feb,

language = "English",

booktitle = "Proceedings of the World Congress on Genetics Applied to Livestock Production",

publisher = "WCGALP",

note = "11th World Congress on Genetics Applied to Livestock Production ; Conference date: 11-02-2018 Through 16-02-2018",

}

Cordero Solorzano, J, Arts, JAJ , Parmentier, HK & Bovenhuis, H 2018, Detection of candidate regions affecting bovine IgM natural antibodies in milk. in Proceedings of the World Congress on Genetics Applied to Livestock Production: Volume Biology - Disease Resistance 1., 559, WCGALP, 11th World Congress on Genetics Applied to Livestock Production, Auckland, New Zealand, 11/02/18. <http://www.wcgalp.org/proceedings/2018/detection-candidate-regions-affecting-bovine-igm-natural-antibodies-milk>

Detection of candidate regions affecting bovine IgM natural antibodies in milk. / Cordero Solorzano, Juan; Arts, J.A.J.; Parmentier, H.K. et al.

Proceedings of the World Congress on Genetics Applied to Livestock Production: Volume Biology - Disease Resistance 1. WCGALP, 2018. 559.

Research output: Chapter in Book/Report/Conference proceeding › Conference paper › Academic

TY - GEN

T1 - Detection of candidate regions affecting bovine IgM natural antibodies in milk

AU - Cordero Solorzano, Juan

AU - Arts, J.A.J.

AU - Parmentier, H.K.

AU - Bovenhuis, H.

PY - 2018/2

Y1 - 2018/2

N2 - Two genomic regions were found to be associated with IgM antibody titers in milk binding lipoteichoic acid (LTA); one on chromosome 17 and the other on chromosome 21. Phenotypes were measured by ELISA and genotypes consisted of imputed 777k SNP. Single SNP analyses were run using an animal model to retrieve significant SNP. In BTA21, a gene for the heavy chains of immunoglobulins, IGHV is proposed as a candidate gene as was true for VPREB3 in BTA17 related to B-cell maturation. These findings provide a further step in better understanding the genetic background of natural antibodies (NAbs), that may be relevant for relevant for the estimation of dairy cattle health. Keywords: dairy cattle, natural antibodies, genome-wide association

AB - Two genomic regions were found to be associated with IgM antibody titers in milk binding lipoteichoic acid (LTA); one on chromosome 17 and the other on chromosome 21. Phenotypes were measured by ELISA and genotypes consisted of imputed 777k SNP. Single SNP analyses were run using an animal model to retrieve significant SNP. In BTA21, a gene for the heavy chains of immunoglobulins, IGHV is proposed as a candidate gene as was true for VPREB3 in BTA17 related to B-cell maturation. These findings provide a further step in better understanding the genetic background of natural antibodies (NAbs), that may be relevant for relevant for the estimation of dairy cattle health. Keywords: dairy cattle, natural antibodies, genome-wide association

M3 - Conference paper

BT - Proceedings of the World Congress on Genetics Applied to Livestock Production

PB - WCGALP

T2 - 11th World Congress on Genetics Applied to Livestock Production

Y2 - 11 February 2018 through 16 February 2018

ER -

Detection of candidate regions affecting bovine IgM natural antibodies in milk

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