Detection of candidate regions affecting bovine IgM natural antibodies in milk

Research output: Chapter in Book/Report/Conference proceedingConference paperAcademic

Abstract

Two genomic regions were found to be associated with IgM antibody titers in milk binding lipoteichoic acid (LTA); one on chromosome 17 and the other on chromosome 21. Phenotypes were measured by ELISA and genotypes consisted of imputed 777k SNP. Single SNP analyses were run using an animal model to retrieve significant SNP. In BTA21, a gene for the heavy chains of immunoglobulins, IGHV is proposed as a candidate gene as was true for VPREB3 in BTA17 related to B-cell maturation. These findings provide a further step in better understanding the genetic background of natural antibodies (NAbs), that may be relevant for relevant for the estimation of dairy cattle health. Keywords: dairy cattle, natural antibodies, genome-wide association
Original languageEnglish
Title of host publicationProceedings of the World Congress on Genetics Applied to Livestock Production
Subtitle of host publicationVolume Biology - Disease Resistance 1
PublisherWCGALP
Number of pages8
Publication statusPublished - Feb 2018
Event11th World Congress on Genetics Applied to Livestock Production - Auckland, New Zealand
Duration: 11 Feb 201816 Feb 2018

Conference

Conference11th World Congress on Genetics Applied to Livestock Production
CountryNew Zealand
CityAuckland
Period11/02/1816/02/18

Fingerprint

milk
antibodies
dairy cattle
cattle
immunoglobulin heavy chains
chromosomes
genetic background
B-lymphocytes
genes
animal models
enzyme-linked immunosorbent assay
genomics
phenotype
genome
genotype
lipoteichoic acids

Cite this

Cordero Solorzano, J., Arts, J. A. J., Parmentier, H. K., & Bovenhuis, H. (2018). Detection of candidate regions affecting bovine IgM natural antibodies in milk. In Proceedings of the World Congress on Genetics Applied to Livestock Production: Volume Biology - Disease Resistance 1 [559] WCGALP.
Cordero Solorzano, Juan ; Arts, J.A.J. ; Parmentier, H.K. ; Bovenhuis, H. / Detection of candidate regions affecting bovine IgM natural antibodies in milk. Proceedings of the World Congress on Genetics Applied to Livestock Production: Volume Biology - Disease Resistance 1. WCGALP, 2018.
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abstract = "Two genomic regions were found to be associated with IgM antibody titers in milk binding lipoteichoic acid (LTA); one on chromosome 17 and the other on chromosome 21. Phenotypes were measured by ELISA and genotypes consisted of imputed 777k SNP. Single SNP analyses were run using an animal model to retrieve significant SNP. In BTA21, a gene for the heavy chains of immunoglobulins, IGHV is proposed as a candidate gene as was true for VPREB3 in BTA17 related to B-cell maturation. These findings provide a further step in better understanding the genetic background of natural antibodies (NAbs), that may be relevant for relevant for the estimation of dairy cattle health. Keywords: dairy cattle, natural antibodies, genome-wide association",
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Cordero Solorzano, J, Arts, JAJ, Parmentier, HK & Bovenhuis, H 2018, Detection of candidate regions affecting bovine IgM natural antibodies in milk. in Proceedings of the World Congress on Genetics Applied to Livestock Production: Volume Biology - Disease Resistance 1., 559, WCGALP, 11th World Congress on Genetics Applied to Livestock Production, Auckland, New Zealand, 11/02/18.

Detection of candidate regions affecting bovine IgM natural antibodies in milk. / Cordero Solorzano, Juan; Arts, J.A.J.; Parmentier, H.K.; Bovenhuis, H.

Proceedings of the World Congress on Genetics Applied to Livestock Production: Volume Biology - Disease Resistance 1. WCGALP, 2018. 559.

Research output: Chapter in Book/Report/Conference proceedingConference paperAcademic

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T1 - Detection of candidate regions affecting bovine IgM natural antibodies in milk

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N2 - Two genomic regions were found to be associated with IgM antibody titers in milk binding lipoteichoic acid (LTA); one on chromosome 17 and the other on chromosome 21. Phenotypes were measured by ELISA and genotypes consisted of imputed 777k SNP. Single SNP analyses were run using an animal model to retrieve significant SNP. In BTA21, a gene for the heavy chains of immunoglobulins, IGHV is proposed as a candidate gene as was true for VPREB3 in BTA17 related to B-cell maturation. These findings provide a further step in better understanding the genetic background of natural antibodies (NAbs), that may be relevant for relevant for the estimation of dairy cattle health. Keywords: dairy cattle, natural antibodies, genome-wide association

AB - Two genomic regions were found to be associated with IgM antibody titers in milk binding lipoteichoic acid (LTA); one on chromosome 17 and the other on chromosome 21. Phenotypes were measured by ELISA and genotypes consisted of imputed 777k SNP. Single SNP analyses were run using an animal model to retrieve significant SNP. In BTA21, a gene for the heavy chains of immunoglobulins, IGHV is proposed as a candidate gene as was true for VPREB3 in BTA17 related to B-cell maturation. These findings provide a further step in better understanding the genetic background of natural antibodies (NAbs), that may be relevant for relevant for the estimation of dairy cattle health. Keywords: dairy cattle, natural antibodies, genome-wide association

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Cordero Solorzano J, Arts JAJ, Parmentier HK, Bovenhuis H. Detection of candidate regions affecting bovine IgM natural antibodies in milk. In Proceedings of the World Congress on Genetics Applied to Livestock Production: Volume Biology - Disease Resistance 1. WCGALP. 2018. 559