Detection of bacterial DNA in bile of cats with lymphocytic cholangitis

C.M.A. Otte, O.N. Pérez, R.P. Favier, J. Rothuizen, L.C. Penning

Research output: Contribution to journalArticleAcademicpeer-review

14 Citations (Scopus)


In this study, we have successfully used molecular methods based on the amplification of the 16S ribosomal RNA gene on feline bile samples to show that bile of cats with LC is not sterile. This is probably due to the fact that the inflammatory process in the biliary tree causes dilatations. As a result, bacteria can easily migrate from the intestines via the common bile duct. The diversity of species identified and the presence of Helicobacter spp. DNA in both patients and controls suggests that bacteriobilia is secondary to the disease and is not the cause of LC.
Original languageEnglish
Pages (from-to)217-221
JournalVeterinary Microbiology
Issue number1-2
Publication statusPublished - 2012


  • 16s ribosomal-rna
  • gradient gel-electrophoresis
  • polymerase-chain-reaction
  • helicobacter-pylori
  • pcr amplification
  • sp-nov.
  • jeotgalicoccus
  • disease
  • liver
  • populations

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