Projects per year
Abstract
De novo mutations arising in the germline add to genetic variation. The number of de novo mutations occurring every generation, especially structural variants, has not been well studied in most species, including livestock. We used whole-genome sequencing from 46 pig trios from two commercial lines to identify de novo structural variants (dnSVs) present in the offspring. We characterised these dnSV by identifying their parent-of-origin, predicting their causal mechanisms, and identifying their functional annotations. We identified four dnSVs, including two clusters of mutations. One of these clusters contained a deletion, and three duplications, one of which was inverted. This cluster was the only dnSV that could be phased and was located in the paternal haplotype of the proband. All four identified dnSVs were located within the introns of genes. Our study is the first of its kind to identify and characterise dnSVs using whole genome shotgun sequence data in pigs.
Original language | English |
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Title of host publication | Proceedings of 12th World Congress on Genetics Applied to Livestock Production (WCGALP) |
Subtitle of host publication | Technical and species orientated innovations in animal breeding, and contribution of genetics to solving societal challenges |
Editors | R.F. Veerkamp, Y. de Haas |
Place of Publication | Wageningen |
Publisher | Wageningen Academic Publishers |
Pages | 2329-2332 |
ISBN (Electronic) | 9789086869404 |
DOIs | |
Publication status | Published - 2022 |
Event | World Congress on Genetics Applied to Livestock Production: WCGALP 2022 - Rotterdam, Netherlands Duration: 3 Jul 2022 → 8 Jul 2022 |
Conference/symposium
Conference/symposium | World Congress on Genetics Applied to Livestock Production: WCGALP 2022 |
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Country/Territory | Netherlands |
City | Rotterdam |
Period | 3/07/22 → 8/07/22 |
Fingerprint
Dive into the research topics of 'Detection and characterisation of de novo structural variants in pigs'. Together they form a unique fingerprint.Projects
- 1 Finished
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AF-16022 Breed4Food II (BO-63-001-009, BO-47-001-021, BO-22.04-025-001, BO-22.04-011-001, BO-22.02-011-001)
Veerkamp, R. (Project Leader)
1/01/14 → 31/12/21
Project: LVVN project