Design principles of a minimal auxin response system

Hirotaka Kato; Sumanth K. Mutte; Hidemasa Suzuki; Isidro Crespo; Shubhajit Das; Tatyana Radoeva; Mattia Fontana; Yoshihiro Yoshitake; Emi Hainiwa; Willy van den Berg; Simon Lindhoud; Kimitsune Ishizaki; Johannes Hohlbein; Jan Willem Borst; Roeland Boer; Ryuichi Nishihama; Takayuki Kohchi; Dolf Weijers

doi:10.1038/s41477-020-0662-y

Design principles of a minimal auxin response system

Hirotaka Kato, Sumanth K. Mutte, Hidemasa Suzuki, Isidro Crespo, Shubhajit Das, Tatyana Radoeva, Mattia Fontana, Yoshihiro Yoshitake, Emi Hainiwa, Willy van den Berg, Simon Lindhoud, Kimitsune Ishizaki, Johannes Hohlbein, Jan Willem Borst, Roeland Boer, Ryuichi Nishihama, Takayuki Kohchi, Dolf Weijers^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

68 Citations (Scopus)

Abstract

Auxin controls numerous growth processes in land plants through a gene expression system that modulates ARF transcription factor activity^1–3. Gene duplications in families encoding auxin response components have generated tremendous complexity in most land plants, and neofunctionalization enabled various unique response outputs during development^1,3,4. However, it is unclear what fundamental biochemical principles underlie this complex response system. By studying the minimal system in Marchantia polymorpha, we derive an intuitive and simple model where a single auxin-dependent A-ARF activates gene expression. It is antagonized by an auxin-independent B-ARF that represses common target genes. The expression patterns of both ARF proteins define developmental zones where auxin response is permitted, quantitatively tuned or prevented. This fundamental design probably represents the ancestral system and formed the basis for inflated, complex systems.

Original language	English
Pages (from-to)	473-482
Number of pages	10
Journal	Nature Plants
Volume	6
Issue number	5
DOIs	https://doi.org/10.1038/s41477-020-0662-y
Publication status	Published - 1 May 2020

Access to Document

10.1038/s41477-020-0662-y

https://edepot.wur.nl/523089Licence: Taverne

Design principles of a minimal auxin response system
Kato, H. (Creator), Mutte, S. K. (Creator), Suzuki, H. (Creator), Crespo, I. (Creator), Das, S. (Creator), Radoeva, T. (Creator), Fontana, M. (Creator), Yoshitake, Y. (Creator), Hainiwa, E. (Creator), van den Berg, W. (Creator), Lindhoud, S. (Creator), Ishizaki, K. (Creator), Hohlbein, J. (Creator), Borst, J. W. (Creator), Boer, R. (Creator), Nishihama, R. (Creator), Kohchi, T. (Creator) & Weijers, D. (Creator), Wageningen University & Research, 13 Jul 2019
https://www.ncbi.nlm.nih.gov/bioproject/554398
Dataset

Cite this

@article{c1df91d1d25d41d2b4b455f2714b5d98,

title = "Design principles of a minimal auxin response system",

abstract = "Auxin controls numerous growth processes in land plants through a gene expression system that modulates ARF transcription factor activity1–3. Gene duplications in families encoding auxin response components have generated tremendous complexity in most land plants, and neofunctionalization enabled various unique response outputs during development1,3,4. However, it is unclear what fundamental biochemical principles underlie this complex response system. By studying the minimal system in Marchantia polymorpha, we derive an intuitive and simple model where a single auxin-dependent A-ARF activates gene expression. It is antagonized by an auxin-independent B-ARF that represses common target genes. The expression patterns of both ARF proteins define developmental zones where auxin response is permitted, quantitatively tuned or prevented. This fundamental design probably represents the ancestral system and formed the basis for inflated, complex systems.",

author = "Hirotaka Kato and Mutte, {Sumanth K.} and Hidemasa Suzuki and Isidro Crespo and Shubhajit Das and Tatyana Radoeva and Mattia Fontana and Yoshihiro Yoshitake and Emi Hainiwa and {van den Berg}, Willy and Simon Lindhoud and Kimitsune Ishizaki and Johannes Hohlbein and Borst, {Jan Willem} and Roeland Boer and Ryuichi Nishihama and Takayuki Kohchi and Dolf Weijers",

year = "2020",

month = may,

day = "1",

doi = "10.1038/s41477-020-0662-y",

language = "English",

volume = "6",

pages = "473--482",

journal = "Nature Plants",

issn = "2055-026X",

publisher = "Nature",

number = "5",

}

TY - JOUR

T1 - Design principles of a minimal auxin response system

AU - Kato, Hirotaka

AU - Mutte, Sumanth K.

AU - Suzuki, Hidemasa

AU - Crespo, Isidro

AU - Das, Shubhajit

AU - Radoeva, Tatyana

AU - Fontana, Mattia

AU - Yoshitake, Yoshihiro

AU - Hainiwa, Emi

AU - van den Berg, Willy

AU - Lindhoud, Simon

AU - Ishizaki, Kimitsune

AU - Hohlbein, Johannes

AU - Borst, Jan Willem

AU - Boer, Roeland

AU - Nishihama, Ryuichi

AU - Kohchi, Takayuki

AU - Weijers, Dolf

PY - 2020/5/1

Y1 - 2020/5/1

N2 - Auxin controls numerous growth processes in land plants through a gene expression system that modulates ARF transcription factor activity1–3. Gene duplications in families encoding auxin response components have generated tremendous complexity in most land plants, and neofunctionalization enabled various unique response outputs during development1,3,4. However, it is unclear what fundamental biochemical principles underlie this complex response system. By studying the minimal system in Marchantia polymorpha, we derive an intuitive and simple model where a single auxin-dependent A-ARF activates gene expression. It is antagonized by an auxin-independent B-ARF that represses common target genes. The expression patterns of both ARF proteins define developmental zones where auxin response is permitted, quantitatively tuned or prevented. This fundamental design probably represents the ancestral system and formed the basis for inflated, complex systems.

AB - Auxin controls numerous growth processes in land plants through a gene expression system that modulates ARF transcription factor activity1–3. Gene duplications in families encoding auxin response components have generated tremendous complexity in most land plants, and neofunctionalization enabled various unique response outputs during development1,3,4. However, it is unclear what fundamental biochemical principles underlie this complex response system. By studying the minimal system in Marchantia polymorpha, we derive an intuitive and simple model where a single auxin-dependent A-ARF activates gene expression. It is antagonized by an auxin-independent B-ARF that represses common target genes. The expression patterns of both ARF proteins define developmental zones where auxin response is permitted, quantitatively tuned or prevented. This fundamental design probably represents the ancestral system and formed the basis for inflated, complex systems.

U2 - 10.1038/s41477-020-0662-y

DO - 10.1038/s41477-020-0662-y

M3 - Article

C2 - 32415296

AN - SCOPUS:85084787001

SN - 2055-026X

VL - 6

SP - 473

EP - 482

JO - Nature Plants

JF - Nature Plants

IS - 5

ER -

Design principles of a minimal auxin response system

Abstract

Access to Document

Fingerprint

Datasets

Design principles of a minimal auxin response system

Cite this